{"id":"https://openalex.org/W2491443887","doi":"https://doi.org/10.1007/978-3-319-30019-1_9","title":"Single-Cell Phenotypic Screening in Inverse Metabolic Engineering","display_name":"Single-Cell Phenotypic Screening in Inverse Metabolic Engineering","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2491443887","doi":"https://doi.org/10.1007/978-3-319-30019-1_9","mag":"2491443887"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-30019-1_9","doi":"https://doi.org/10.1007/978-3-319-30019-1_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-30019-1_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microfluidic Methods for Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2490777982","display_name":"Microfluidic Methods for Molecular Biology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003221941","display_name":"Andreas E. Vasdekis","orcid":"https://orcid.org/0000-0003-4315-1047","observed_orcids":["https://orcid.org/0000-0003-4315-1047"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. E. Vasdekis","raw_affiliation_strings":["Department of Physics, University of Idaho, Moscow, ID, 83844, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Idaho, Moscow, ID, 83844, USA","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003221941"],"corresponding_institution_ids":["https://openalex.org/I155093810"],"apc_list":null,"apc_paid":null,"fwci":0.8265,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70276062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"189","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inverse-metabolic-engineering","display_name":"inverse metabolic engineering","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mutant-library","display_name":"mutant library","score":0.7170000076293945},{"id":"https://openalex.org/keywords/fluorescence-activated-cell-sorting","display_name":"fluorescence-activated cell sorting","score":0.9559999704360962},{"id":"https://openalex.org/keywords/droplet-microfluidics","display_name":"droplet microfluidics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/secretory-phenotype","display_name":"secretory phenotype","score":0.48899999260902405},{"id":"https://openalex.org/keywords/substrate-consumption","display_name":"substrate consumption","score":0.4699999988079071},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7186641693115234},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.6602771878242493},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5875645875930786},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.5776451826095581},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5696321725845337},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5598811507225037},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.5472216606140137},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5217757821083069},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5155415534973145},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5149865746498108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4299378991127014},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4147416651248932},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3520694971084595},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27957335114479065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26547449827194214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24234935641288757},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23989340662956238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16071832180023193},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08529490232467651},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-30019-1_9","doi":"https://doi.org/10.1007/978-3-319-30019-1_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-30019-1_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microfluidic Methods for Molecular Biology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1493227903","https://openalex.org/W1498373892","https://openalex.org/W1574470162","https://openalex.org/W1864427654","https://openalex.org/W1964144538","https://openalex.org/W1967053372","https://openalex.org/W1967197994","https://openalex.org/W1970292634","https://openalex.org/W1970654358","https://openalex.org/W1976016203","https://openalex.org/W1976609472","https://openalex.org/W1981233250","https://openalex.org/W1984321826","https://openalex.org/W1985031615","https://openalex.org/W1991050404","https://openalex.org/W1992712806","https://openalex.org/W1995316170","https://openalex.org/W1995528755","https://openalex.org/W1995924881","https://openalex.org/W1999195584","https://openalex.org/W2008497184","https://openalex.org/W2009434334","https://openalex.org/W2010173857","https://openalex.org/W2013573429","https://openalex.org/W2015926680","https://openalex.org/W2018866375","https://openalex.org/W2026726511","https://openalex.org/W2030692069","https://openalex.org/W2030782592","https://openalex.org/W2032349705","https://openalex.org/W2033235640","https://openalex.org/W2034645234","https://openalex.org/W2037060512","https://openalex.org/W2038727507","https://openalex.org/W2043628508","https://openalex.org/W2045167474","https://openalex.org/W2058748791","https://openalex.org/W2058991361","https://openalex.org/W2064492983","https://openalex.org/W2066885996","https://openalex.org/W2071624306","https://openalex.org/W2075332549","https://openalex.org/W2075591632","https://openalex.org/W2077046573","https://openalex.org/W2077582218","https://openalex.org/W2079718713","https://openalex.org/W2082140226","https://openalex.org/W2091198609","https://openalex.org/W2092058433","https://openalex.org/W2092092194","https://openalex.org/W2092727311","https://openalex.org/W2098803683","https://openalex.org/W2100542429","https://openalex.org/W2100717755","https://openalex.org/W2101700211","https://openalex.org/W2105776288","https://openalex.org/W2109918485","https://openalex.org/W2113033658","https://openalex.org/W2114447844","https://openalex.org/W2114764875","https://openalex.org/W2116137883","https://openalex.org/W2117179092","https://openalex.org/W2123378400","https://openalex.org/W2123398097","https://openalex.org/W2124875555","https://openalex.org/W2131350482","https://openalex.org/W2134153749","https://openalex.org/W2136536485","https://openalex.org/W2141789961","https://openalex.org/W2142423992","https://openalex.org/W2148307778","https://openalex.org/W2151555227","https://openalex.org/W2153588917","https://openalex.org/W2159026197","https://openalex.org/W2159445822","https://openalex.org/W2159941442","https://openalex.org/W2168909179","https://openalex.org/W2171501288","https://openalex.org/W2290771681","https://openalex.org/W2291673926","https://openalex.org/W2438537421","https://openalex.org/W4239632189","https://openalex.org/W4256685593"],"related_works":["https://openalex.org/W2286884095","https://openalex.org/W2435086555","https://openalex.org/W2375450111","https://openalex.org/W2003566497","https://openalex.org/W2005063728","https://openalex.org/W3026225702","https://openalex.org/W3045267663","https://openalex.org/W2769084248","https://openalex.org/W2901896603","https://openalex.org/W2141789961"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}