{"id":"https://openalex.org/W2491368445","doi":"https://doi.org/10.1007/978-1-60761-529-3_4","title":"Prediction of Blood\u2013Brain Barrier Penetration by Drugs","display_name":"Prediction of Blood\u2013Brain Barrier Penetration by Drugs","publication_year":2009,"publication_date":"2009-11-25","ids":{"openalex":"https://openalex.org/W2491368445","doi":"https://doi.org/10.1007/978-1-60761-529-3_4","mag":"2491368445"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-529-3_4","doi":"https://doi.org/10.1007/978-1-60761-529-3_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-529-3_4","pdf_url":null,"source":{"id":"https://openalex.org/S4210197300","display_name":"Neuromethods","issn_l":"0893-2336","issn":["0893-2336","1940-6045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuromethods","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1561552940","display_name":"Drug Delivery to the Central Nervous System"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090656712","display_name":"Kiril Lanevskij","orcid":"https://orcid.org/0000-0001-7419-8169","observed_orcids":["https://orcid.org/0000-0001-7419-8169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiril Lanevskij","raw_affiliation_strings":["Pharma Algorithms Inc, Vilnius, Lithuania","Pharma Algorithms Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Algorithms Inc, Vilnius, Lithuania","institution_ids":[]},{"raw_affiliation_string":"Pharma Algorithms Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012501898","display_name":"Pranas Japertas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pranas Japertas","raw_affiliation_strings":["Pharma Algorithms Inc, Vilnius, Lithuania","Pharma Algorithms Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Algorithms Inc, Vilnius, Lithuania","institution_ids":[]},{"raw_affiliation_string":"Pharma Algorithms Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039031718","display_name":"Remigijus Did\u017eiapetris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Remigijus Didziapetris","raw_affiliation_strings":["Pharma Algorithms Inc, Vilnius, Lithuania","Pharma Algorithms Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Algorithms Inc, Vilnius, Lithuania","institution_ids":[]},{"raw_affiliation_string":"Pharma Algorithms Inc","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041209377","display_name":"Alanas A. Petrauskas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alanas Petrauskas","raw_affiliation_strings":["Pharma Algorithms Inc, Vilnius, Lithuania","Pharma Algorithms Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Algorithms Inc, Vilnius, Lithuania","institution_ids":[]},{"raw_affiliation_string":"Pharma Algorithms Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0348,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.82403433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"63","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7910000085830688},{"id":"https://openalex.org/keywords/passive-diffusion","display_name":"passive diffusion","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-uptake","display_name":"brain uptake","score":0.7570000290870667},{"id":"https://openalex.org/keywords/in-silico-prediction","display_name":"in silico prediction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mechanistic-modeling","display_name":"mechanistic modeling","score":0.7089999914169312},{"id":"https://openalex.org/keywords/descriptor-selection","display_name":"descriptor selection","score":0.8299999833106995},{"id":"https://openalex.org/keywords/data-quality","display_name":"data quality","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7078330516815186},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.5850907564163208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3351043164730072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19052967429161072},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1898699700832367},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15659230947494507},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.06725087761878967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-60761-529-3_4","doi":"https://doi.org/10.1007/978-1-60761-529-3_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-529-3_4","pdf_url":null,"source":{"id":"https://openalex.org/S4210197300","display_name":"Neuromethods","issn_l":"0893-2336","issn":["0893-2336","1940-6045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuromethods","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W16603568","https://openalex.org/W54720803","https://openalex.org/W1531182311","https://openalex.org/W1594597698","https://openalex.org/W1963813830","https://openalex.org/W1966259921","https://openalex.org/W1968478164","https://openalex.org/W1970263371","https://openalex.org/W1990299751","https://openalex.org/W1991064261","https://openalex.org/W1992983740","https://openalex.org/W1997484187","https://openalex.org/W1997739799","https://openalex.org/W2000897683","https://openalex.org/W2013280216","https://openalex.org/W2018872680","https://openalex.org/W2019695588","https://openalex.org/W2022995595","https://openalex.org/W2024317644","https://openalex.org/W2033495141","https://openalex.org/W2040972896","https://openalex.org/W2041487061","https://openalex.org/W2043355351","https://openalex.org/W2056475298","https://openalex.org/W2058780134","https://openalex.org/W2062693496","https://openalex.org/W2067223842","https://openalex.org/W2070440937","https://openalex.org/W2076448934","https://openalex.org/W2078622722","https://openalex.org/W2082214060","https://openalex.org/W2083025840","https://openalex.org/W2087381150","https://openalex.org/W2087908817","https://openalex.org/W2097069952","https://openalex.org/W2101099825","https://openalex.org/W2117024164","https://openalex.org/W2120971910","https://openalex.org/W2126205988","https://openalex.org/W2126305917","https://openalex.org/W2129219544","https://openalex.org/W2144254013","https://openalex.org/W2146875037","https://openalex.org/W2155881411","https://openalex.org/W2166269667","https://openalex.org/W2203195025","https://openalex.org/W2220807183","https://openalex.org/W2329365935","https://openalex.org/W2342023071","https://openalex.org/W2405887519","https://openalex.org/W2423210039","https://openalex.org/W2767707571","https://openalex.org/W4300720636"],"related_works":["https://openalex.org/W58245324","https://openalex.org/W1984360588","https://openalex.org/W2767948131","https://openalex.org/W1994751724","https://openalex.org/W2000208781","https://openalex.org/W2409813302","https://openalex.org/W45411166","https://openalex.org/W2156014915","https://openalex.org/W2762493662","https://openalex.org/W1953282970"],"abstract_inverted_index":{"This":[0],"chapter":[1,52],"presents":[2],"a":[3,54],"mechanistic":[4],"approach":[5],"to":[6,22],"in":[7],"silico":[8],"prediction":[9],"of":[10,25,65],"blood\u2013brain":[11,69],"barrier":[12],"penetration":[13],"by":[14],"drugs":[15],"and":[16,61,80],"drug-like":[17],"molecules.":[18],"Focus":[19],"is":[20],"brought":[21],"critical":[23],"analysis":[24],"experimental":[26,40],"data":[27,34],"used":[28,42],"for":[29,43,57],"modeling;":[30],"several":[31],"factors":[32],"affecting":[33],"quality":[35],"are":[36,47],"discussed.":[37],"The":[38,51],"main":[39],"techniques":[41],"measuring":[44],"brain":[45],"uptake":[46],"also":[48],"briefly":[49],"reviewed.":[50],"provides":[53],"theoretical":[55],"background":[56],"obtaining":[58],"physicochemically":[59],"reasonable":[60],"easily":[62],"interpretable":[63],"predictions":[64],"passive":[66],"diffusion":[67],"across":[68],"barrier,":[70],"as":[71,73],"well":[72],"some":[74],"general":[75],"advices":[76],"regarding":[77],"descriptor":[78],"selection":[79],"model":[81],"development.":[82]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}