{"id":"https://openalex.org/W2491279813","doi":"https://doi.org/10.1158/1538-7445.am2016-4001","title":"Abstract 4001: The anti-CD47 antibody Hu5F9-G4 activates macrophages and inhibits ovarian cancer xenografts, alone and in combination with chemotherapy or immunotherapy","display_name":"Abstract 4001: The anti-CD47 antibody Hu5F9-G4 activates macrophages and inhibits ovarian cancer xenografts, alone and in combination with chemotherapy or immunotherapy","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2491279813","doi":"https://doi.org/10.1158/1538-7445.am2016-4001","mag":"2491279813"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-4001","doi":"https://doi.org/10.1158/1538-7445.am2016-4001","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016003061","display_name":"Rishil J. Kathawala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rishil J. Kathawala","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080903264","display_name":"David C Mundy","orcid":"https://orcid.org/0000-0001-5594-7945","observed_orcids":["https://orcid.org/0000-0001-5594-7945"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Mundy","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049738459","display_name":"George E. Dur\u00e1n","orcid":"https://orcid.org/0000-0003-2692-3906","observed_orcids":["https://orcid.org/0000-0003-2692-3906"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George E. Duran","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009306261","display_name":"Jens-Peter Volkmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jens-Peter Volkmer","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086445311","display_name":"Kevin Shuolong Kao","orcid":"https://orcid.org/0000-0003-1918-2097","observed_orcids":["https://orcid.org/0000-0003-1918-2097"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin S. Kao","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091119871","display_name":"Yan C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan C. Wang","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086694563","display_name":"Aditi Bellary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Bellary","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082894731","display_name":"Irving L. Weissman","orcid":"https://orcid.org/0000-0002-9077-7467","observed_orcids":["https://orcid.org/0000-0002-9077-7467"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irving L. Weissman","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019649110","display_name":"Branimir Ivan Sikic","orcid":"https://orcid.org/0000-0001-6814-2070","observed_orcids":["https://orcid.org/0000-0001-6814-2070"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Branimir I. Sikic","raw_affiliation_strings":["Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"4001","last_page":"4001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-cd47-antibody","display_name":"anti-CD47 antibody","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cd47-blockade","display_name":"CD47 blockade","score":0.6309999823570251},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/taxane-resistance","display_name":"taxane resistance","score":0.8029999732971191},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.7039999961853027},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9269999861717224},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8569999933242798},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.44999998807907104},{"id":"https://openalex.org/keywords/xenograft-imaging","display_name":"xenograft imaging","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2780104668","wikidata":"https://www.wikidata.org/wiki/Q21108354","display_name":"CD47","level":3,"score":0.9018051028251648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6538934707641602},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5308747291564941},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49120041728019714},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4747196435928345},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.4353324770927429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4026418924331665},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36076897382736206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34638887643814087},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3386864960193634},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31240442395210266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2531876564025879},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2434006929397583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20490345358848572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-4001","doi":"https://doi.org/10.1158/1538-7445.am2016-4001","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020011267","https://openalex.org/W2739628025","https://openalex.org/W7165060444","https://openalex.org/W3193360638","https://openalex.org/W3083339974","https://openalex.org/W2531623908","https://openalex.org/W2603831404","https://openalex.org/W4407625318","https://openalex.org/W2548828532","https://openalex.org/W4384652491"],"abstract_inverted_index":{"Abstract":[0],"Macrophage":[1],"activation":[2],"by":[3,37,72,112,207,226],"inhibition":[4,245],"of":[5,16,45,53,133,150,219,262,267,289,444,449],"CD47":[6,17,32,39,111,134,214,375],"signaling":[7],"is":[8,123],"a":[9,25,124,154,260,377],"new":[10],"therapeutic":[11,378],"approach":[12],"to":[13,18,75,99],"cancers.":[14,55],"Binding":[15],"its":[19],"receptor":[20],"SIRP\u03b1":[21,36],"on":[22],"macrophages":[23,228,427],"initiates":[24],"signal":[26,126],"cascade":[27],"that":[28,127,181,188,297,384],"inhibits":[29,429],"phagocytosis.":[30],"Blocking":[31,213],"from":[33,61,230],"interaction":[34],"with":[35,165,173,242,356,367,390,437],"the":[38,79,131,141,148,196,265,292,300,309,320,445,450],"antibody":[40,310,322,424],"Hu5F9-G4":[41,234,306,324,341,344,425],"results":[42,373],"in":[43,51,85,88,92,130,140,157,179,195,215,239,291,348,380,435],"phagocytosis":[44,129,218],"cancer":[46,198,431],"cells,":[47],"and":[48,70,78,90,114,117,160,167,170,190,209,221,264,308,334,351,359,361,364,382,392,428,434],"anticancer":[49],"activity":[50,238],"xenografts":[52,369],"human":[54,62],"We":[56,145,186],"developed":[57],"taxane":[58],"resistant":[59,161],"variants":[60,143],"ovarian":[63,197,430],"carcinoma":[64],"(OC)":[65],"cell":[66,224],"lines":[67,96,204,225],"(ES-2,":[68],"MES-OV":[69,240,349],"OVCAR-3)":[71],"step-wise":[73],"exposure":[74],"paclitaxel":[76],"(Ptx)":[77],"transport":[80],"inhibitor":[81],"valspodar":[82],"(6x":[83],"resistance":[84],"ES-2/TP,":[86],"9x":[87],"MES-OV/TP,":[89],"30x":[91],"OVCAR-3/TP).":[93],"These":[94,372],"6":[95,202],"were":[97],"transduced":[98],"establish":[100],"stable":[101],"luciferase":[102],"expression":[103],"for":[104,302,453],"OC":[105,203,223],"xenograft":[106],"(OCX)":[107],"imaging.":[108],"All":[109,201],"express":[110,119,182,205,211],"immunoblotting":[113],"flow":[115],"cytometry,":[116],"all":[118],"calreticulin":[120],"(CRT).":[121],"CRT":[122,136],"prophagocytic":[125],"promotes":[128],"presence":[132],"blockade.":[135],"levels":[137],"are":[138,146,192,370],"lower":[139],"Ptx-resistant":[142],"(p<0.01).":[144],"assessing":[147],"efficacy":[149,347],"Hu5F9-G4:":[151],"(1)":[152],"as":[153,376],"single":[155,236,317],"agent":[156,237],"drug":[158],"sensitive":[159],"OCX;":[162],"(2)":[163],"combined":[164,172,321,389],"Ptx":[166,257],"carboplatin":[168],"(Carbo);":[169],"(3)":[171],"cetuximab":[174],"(Cetux)":[175],"or":[176,439],"trastuzumab":[177],"(Trastuz)":[178],"OCX":[180],"EGFR":[183,189,206],"and/or":[184],"HER2.":[185,212],"found":[187],"HER2":[191],"highly":[193],"expressed":[194],"TCGA":[199],"database.":[200],"immunoblotting,":[208],"4":[210],"vitro":[216],"induces":[217],"parental":[220],"drug-resistant":[222],"murine":[227],"derived":[229],"NOD/SCIDgamma":[231],"(NSG)":[232],"mice.":[233],"has":[235,345],"OCX,":[241,350],"89%":[243],"growth":[244],"at":[246,285,296,352],"9":[247],"weeks":[248,287],"(T/C":[249],"11%)":[250],"vs":[251,273,278,315,340],"untreated":[252],"controls":[253],"(p":[254,270,337],"=":[255,271,276,338],"0.03).":[256],"alone":[258,433],"produced":[259],"T/C":[261,301,325],"29%,":[263],"combination":[266,312,436],"Ptx/Hu5F9-G4":[268],"3%":[269],"0.03":[272],"Hu5F9-G4;":[274],"p":[275],"0.0002":[277],"Ptx).":[279],"The":[280,422],"Carbo":[281,293,303],"experiment":[282],"was":[283,304,326],"terminated":[284],"5":[286],"because":[288],"toxicity":[290],"groups,":[294],"but":[295],"time":[298],"point":[299],"59%,":[305],"20%,":[307],"combination/carboplatin":[311],"4%":[313],"(p<0.005":[314],"either":[316],"agent).":[318],"In":[319],"experiment,":[323],"23%,":[327],"Cetux":[328],"84%,":[329],"Trastuz":[330],"37%,":[331],"Hu5F9-G4/Cetux":[332],"13%,":[333],"Hu5F9-G4/Trastuz":[335],"12%":[336],"0.05":[339],"alone).":[342],"Thus,":[343],"substantial":[346],"least":[353],"additive":[354],"effects":[355],"chemotherapy":[357,438],"(Ptx":[358],"Carbo)":[360],"immunotherapy":[362],"(Cetux":[363],"Trastuz).":[365],"Experiments":[366],"other":[368,393],"continuing.":[371],"support":[374],"target":[379],"OC,":[381],"suggest":[383],"it":[385],"may":[386],"be":[387],"successfully":[388],"chemotherapies":[391],"antibodies.":[394],"Citation":[395],"Format:":[396],"Rishil":[397],"J.":[398],"Kathawala,":[399],"David":[400],"C.":[401,412],"Mundy,":[402],"George":[403],"E.":[404],"Duran,":[405],"Jens-Peter":[406],"Volkmer,":[407],"Kevin":[408],"S.":[409],"Kao,":[410],"Yan":[411],"Wang,":[413],"Aditi":[414],"Bellary,":[415],"Irving":[416],"L.":[417],"Weissman,":[418],"Branimir":[419],"I.":[420],"Sikic.":[421],"anti-CD47":[423],"activates":[426],"xenografts,":[432],"immunotherapy.":[440],"[abstract].":[441],"In:":[442],"Proceedings":[443],"107th":[446],"Annual":[447],"Meeting":[448],"American":[451],"Association":[452],"Cancer":[454,465],"Research;":[455],"2016":[456],"Apr":[457],"16-20;":[458],"New":[459],"Orleans,":[460],"LA.":[461],"Philadelphia":[462],"(PA):":[463],"AACR;":[464],"Res":[466],"2016;76(14":[467],"Suppl):Abstract":[468],"nr":[469],"4001.":[470]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-08-23T00:00:00"}