{"id":"https://openalex.org/W2490905454","doi":"https://doi.org/10.1182/blood.v112.11.1168.1168","title":"Selective Allodepletion by TH9402-Mediated Photosensitization Results in Early Full Donor T Cell Reconstitution in the Absence of High-Grade, Acute GvHD and Is Associated with Favorable Outcome after HLA Matched Sibling SCT for Hematologic Malignancies","display_name":"Selective Allodepletion by TH9402-Mediated Photosensitization Results in Early Full Donor T Cell Reconstitution in the Absence of High-Grade, Acute GvHD and Is Associated with Favorable Outcome after HLA Matched Sibling SCT for Hematologic Malignancies","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2490905454","doi":"https://doi.org/10.1182/blood.v112.11.1168.1168","mag":"2490905454"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.1168.1168","doi":"https://doi.org/10.1182/blood.v112.11.1168.1168","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1168.1168","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049107543","display_name":"Stephan Mielke","orcid":"https://orcid.org/0000-0002-8325-9215","observed_orcids":["https://orcid.org/0000-0002-8325-9215"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Mielke","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH) (current address: University of Wuerzburg, Germany), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH) (current address: University of Wuerzburg, Germany), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035962607","display_name":"Aarthi G. Shenoy","orcid":"https://orcid.org/0000-0002-5018-8967","observed_orcids":["https://orcid.org/0000-0002-5018-8967"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarthi Shenoy","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088037619","display_name":"Vicki S. Fellowes","orcid":"https://orcid.org/0009-0007-0810-2051","observed_orcids":["https://orcid.org/0009-0007-0810-2051"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicki S. Fellowes","raw_affiliation_strings":["Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007244861","display_name":"Katayoun Rezvani","orcid":"https://orcid.org/0000-0002-9599-2246","observed_orcids":["https://orcid.org/0000-0002-9599-2246"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katayoun Rezvani","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088962035","display_name":"Bipin N. Savani","orcid":"https://orcid.org/0000-0002-3304-9965","observed_orcids":["https://orcid.org/0000-0002-3304-9965"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bipin N. Savani","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051072524","display_name":"Laura Musse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Musse","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043651824","display_name":"Laura B. Wisch","orcid":"https://orcid.org/0009-0003-6897-205X","observed_orcids":["https://orcid.org/0009-0003-6897-205X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Wisch","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005077693","display_name":"Roger J. Kurlander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Kurlander","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087049535","display_name":"Hanh M. Khuu","orcid":"https://orcid.org/0009-0005-8199-117X","observed_orcids":["https://orcid.org/0009-0005-8199-117X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanh Khuu","raw_affiliation_strings":["Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059096564","display_name":"Carol Boss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Boss","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049066393","display_name":"A. John Barrett","orcid":"https://orcid.org/0000-0002-6082-4437","observed_orcids":["https://orcid.org/0000-0002-6082-4437"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. John Barrett","raw_affiliation_strings":["Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allotransplantation Section, Hematology Branch, NHLBI, National Institutes of Health (NIH), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2156,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63618982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"1168","last_page":"1168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photosensitization","display_name":"photosensitization","score":0.921999990940094},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hla-matched-sibling-transplantation","display_name":"HLA-matched sibling transplantation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cd34-cell-selection","display_name":"CD34+ cell selection","score":0.6579999923706055},{"id":"https://openalex.org/keywords/low-dose-cyclosporine","display_name":"low-dose cyclosporine","score":0.7919999957084656},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.5509999990463257},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.5509999990463257},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6358038187026978},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5442112684249878},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5145372748374939},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.493307501077652},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.4911198318004608},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4320322871208191},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4149879813194275},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41378456354141235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3755432069301605},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2852778434753418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17354780435562134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.1168.1168","doi":"https://doi.org/10.1182/blood.v112.11.1168.1168","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1168.1168","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2560409870","https://openalex.org/W2553729218","https://openalex.org/W2560300963","https://openalex.org/W2571432015","https://openalex.org/W2018577692","https://openalex.org/W2131140289","https://openalex.org/W1975957804","https://openalex.org/W2565540055","https://openalex.org/W2587344323","https://openalex.org/W2969955781"],"abstract_inverted_index":{"Abstract":[0],"Selective":[1],"allodepletion":[2],"(SD)":[3],"is":[4],"a":[5,28,76,96,109,175,190,195,260,373,378],"strategy":[6],"to":[7,14,68,72,206,258,400],"eliminate":[8],"host-reactive":[9],"donor":[10,24,55,130,370],"T-cells":[11],"from":[12],"allografts":[13],"prevent":[15],"graft":[16],"versus":[17],"host":[18],"disease":[19,402],"(GvHD)":[20],"while":[21],"conserving":[22],"useful":[23],"immunity.":[25],"We":[26],"developed":[27,269,296],"semi-closed,":[29],"GMP-quality,":[30],"clinical":[31,97,354],"scale":[32],"SD":[33,129,208,358,384],"process":[34],"where":[35,99],"donor-derived":[36],"lymphocytes":[37,291],"are":[38],"stimulated":[39],"with":[40,103,124,162,174,372],"patient-derived":[41],"T-cell":[42],"antigen":[43],"presenting":[44],"cells":[45,57,132,203,386],"in":[46,75,150,204,263,329,362,377,387,404],"an":[47,137,255,326],"ex":[48],"vivo":[49],"mixed":[50],"lymphocyte":[51,212,366],"reaction":[52],"(MLR).":[53],"Alloactivated":[54],"T":[56,121,131,209,227,264,385],"preferentially":[58],"retain":[59],"the":[60,151,289,351,388],"photosensitizer":[61],"4,5-dibromorhodamine":[62],"123":[63],"(TH9402),":[64],"rendering":[65],"them":[66],"susceptible":[67],"elimination":[69],"by":[70],"exposure":[71],"visible":[73],"light":[74],"photodepletion":[77],"device":[78],"(Kiadis":[79],"Pharma":[80],"Inc,":[81],"The":[82],"Netherlands).":[83],"After":[84],"Food":[85],"and":[86,89,238,244,277,318,368],"Drug":[87],"Administration":[88],"Institutional":[90],"Review":[91],"Board":[92],"approval":[93],"we":[94],"initiated":[95],"trial":[98],"HLA-identical":[100],"sibling":[101],"recipients":[102],"hematological":[104],"(non":[105],"T-cell)":[106],"malignancies":[107],"received":[108,189,254],"CD34-cell":[110],"selected":[111],"transplant":[112,323],"(Miltenyi,":[113],"Germany)":[114],"containing":[115,194],"less":[116],"then":[117],"1":[118],"\u00d7":[119,126],"104":[120],"cells/kg":[122],"together":[123],"5":[125],"106/kg":[127],"viable":[128],"on":[133,235,241,247],"day":[134,220,236,242,248],"0,":[135],"using":[136],"age-adapted,":[138],"radiation-based":[139],"preparative":[140],"regimen":[141],"(FluCyTBI).":[142],"Low-dose":[143],"cyclosporine":[144],"was":[145,214,230],"used":[146],"as":[147],"sole":[148],"immunosuppression":[149,399],"absence":[152,389],"of":[153,178,197,274,288,315,356,383,390,398],"GvHD.":[154,299],"Eleven":[155],"patients":[156,183,268,295,340],"(median":[157,216,232],"age":[158],"43":[159],"(28\u201368)":[160],"years":[161],"ALL,":[163],"MDS,":[164],"CML,":[165],"mantle":[166],"cell":[167,192,228,265,360],"lymphoma":[168],"(MCL),":[169],"or":[170],"AML)":[171],"were":[172,184,344],"transplanted":[173,303],"median":[176,196],"follow-up":[177],"240":[179],"(43\u2013400)":[180],"days.":[181],"Nine":[182],"considered":[185],"high":[186],"risk.":[187],"Patients":[188],"stem":[191,202,359],"product":[193],"6.0":[198],"(3.9\u20139.5)":[199],"\u00d7106/kg":[200],"CD34+":[201],"addition":[205],"5\u00d7106/kg":[207],"cells.":[210],"Absolute":[211],"recovery":[213,367],"rapid":[215],"834":[217],"(384\u20132486)":[218],"cells/\u03bcL":[219],"30":[221],"post":[222],"transplant)":[223],"[Fig":[224,250,292],"A].":[225],"Early":[226],"chimerism":[229,371],"donor-dominated":[231],"66%":[233],"(6\u201395)":[234],"14,":[237],"97%":[239],"(82\u2013100)":[240],"30,":[243],"100%":[245],"(92\u2013100)":[246],"45":[249],"B].":[251],"One":[252,312],"patient":[253,313],"unmanipulated":[256,327],"DLI":[257,328],"treat":[259],"delayed":[261],"fall":[262],"chimerism.":[266],"Three":[267],"steroid-sensitive":[270],"grade":[271,282],"II":[272],"aGvHD":[273,284],"skin":[275],"(N=2)":[276],"gut":[278],"(N=1)":[279],"but":[280,335,343],"no":[281],"III\u2013IV":[283],"occurred":[285],"after":[286,310,322,324],"transfusion":[287],"photodepleted":[290],"C].":[293],"Two":[294],"limited":[297],"chronic":[298],"Only":[300],"one":[301],"patient,":[302],"for":[304,333,350],"refractory":[305],"MCL,":[306],"relapsed":[307],"340":[308],"days":[309,321],"transplant.":[311],"died":[314],"infectious":[316],"complications":[317],"GvHD":[319],"330":[320],"receiving":[325],"her":[330],"home":[331],"country":[332],"suspected,":[334],"subsequently":[336],"unconfirmed":[337],"relapse.":[338],"Eight":[339],"reactivated":[341],"CMV":[342],"successfully":[345],"treated.":[346],"These":[347],"results":[348],"demonstrate":[349],"first":[352],"time":[353],"feasibility":[355],"photodepletion-based":[357],"allotransplants":[361],"matched":[363],"siblings.":[364],"Robust":[365],"early":[369],"low":[374],"relapse":[375],"incidence":[376],"high-risk":[379],"population":[380],"suggest":[381],"functionality":[382],"severe":[391],"GvHD,":[392],"which":[393],"should":[394],"allow":[395],"further":[396],"reduction":[397],"optimize":[401],"control":[403],"future":[405],"studies.":[406]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-08-23T00:00:00"}