{"id":"https://openalex.org/W2490855869","doi":"https://doi.org/10.1080/15287394.2016.1204577","title":"Adverse effects of bisphenol A (BPA) on the dopamine system in two distinct cell models and corpus striatum of the Sprague-Dawley rat","display_name":"Adverse effects of bisphenol A (BPA) on the dopamine system in two distinct cell models and corpus striatum of the Sprague-Dawley rat","publication_year":2016,"publication_date":"2016-08-05","ids":{"openalex":"https://openalex.org/W2490855869","doi":"https://doi.org/10.1080/15287394.2016.1204577","mag":"2490855869","pmid":"https://pubmed.ncbi.nlm.nih.gov/27494678"},"language":"en","primary_location":{"id":"doi:10.1080/15287394.2016.1204577","doi":"https://doi.org/10.1080/15287394.2016.1204577","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2016.1204577","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035798619","display_name":"Brittney A. Nowicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brittney A. Nowicki","raw_affiliation_strings":["AZCOM, Midwestern University, Glendale, AZ, 85308 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AZCOM, Midwestern University, Glendale, AZ, 85308 USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083021379","display_name":"Matt A. Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt A. Hamada","raw_affiliation_strings":["AZCOM, Midwestern University, Glendale, AZ, 85308 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AZCOM, Midwestern University, Glendale, AZ, 85308 USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089492506","display_name":"Gina Y. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina Y. Robinson","raw_affiliation_strings":["AZCOM, Midwestern University, Glendale, AZ, 85308 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AZCOM, Midwestern University, Glendale, AZ, 85308 USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111338529","display_name":"Douglas C. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Jones","raw_affiliation_strings":["AZCOM, Midwestern University, Glendale, AZ, 85308 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AZCOM, Midwestern University, Glendale, AZ, 85308 USA","institution_ids":["https://openalex.org/I128902783"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035798619"],"corresponding_institution_ids":["https://openalex.org/I128902783"],"apc_list":null,"apc_paid":null,"fwci":0.7188,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66061138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"79","issue":"20","first_page":"912","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":1.0},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.875},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dopamine-uptake","display_name":"dopamine uptake","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gh3-cells","display_name":"GH3 cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.5920000076293945},{"id":"https://openalex.org/keywords/maternal-transfer","display_name":"maternal transfer","score":0.6140000224113464},{"id":"https://openalex.org/keywords/dietary-exposure","display_name":"dietary exposure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neuroendocrine-effects","display_name":"neuroendocrine effects","score":0.4959999918937683},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7356045246124268},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6902015209197998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6524239778518677},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.6266838908195496},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6108887791633606},{"id":"https://openalex.org/C2779684741","wikidata":"https://www.wikidata.org/wiki/Q271980","display_name":"Bisphenol A","level":3,"score":0.5391095280647278},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5049362778663635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.497844934463501},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.4773550033569336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33191758394241333},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.2192516028881073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1975644826889038},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11578980088233948},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10097721219062805},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C166595027","wikidata":"https://www.wikidata.org/wiki/Q143983","display_name":"Epoxy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000098826","descriptor_name":"Bisphenol A Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287394.2016.1204577","doi":"https://doi.org/10.1080/15287394.2016.1204577","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2016.1204577","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},{"id":"pmid:27494678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27494678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313823","display_name":"Midwestern University","ror":"https://ror.org/046yatd98"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W298469504","https://openalex.org/W750371492","https://openalex.org/W1510038113","https://openalex.org/W1543786573","https://openalex.org/W1595909085","https://openalex.org/W1769327505","https://openalex.org/W1966215085","https://openalex.org/W1967017238","https://openalex.org/W1970760886","https://openalex.org/W1972860010","https://openalex.org/W1976182007","https://openalex.org/W1982477373","https://openalex.org/W1985797496","https://openalex.org/W1986018940","https://openalex.org/W1986519131","https://openalex.org/W1987388185","https://openalex.org/W1987538361","https://openalex.org/W1987722108","https://openalex.org/W1995715269","https://openalex.org/W1996084338","https://openalex.org/W2004608396","https://openalex.org/W2005706424","https://openalex.org/W2008799105","https://openalex.org/W2008934479","https://openalex.org/W2013068635","https://openalex.org/W2016527659","https://openalex.org/W2016639841","https://openalex.org/W2018381563","https://openalex.org/W2025292518","https://openalex.org/W2035817290","https://openalex.org/W2041124206","https://openalex.org/W2041901223","https://openalex.org/W2044295177","https://openalex.org/W2052074823","https://openalex.org/W2052927712","https://openalex.org/W2053706866","https://openalex.org/W2054204220","https://openalex.org/W2062520652","https://openalex.org/W2063517792","https://openalex.org/W2063651144","https://openalex.org/W2064854818","https://openalex.org/W2066342358","https://openalex.org/W2068800492","https://openalex.org/W2074403754","https://openalex.org/W2074761764","https://openalex.org/W2081769431","https://openalex.org/W2087370445","https://openalex.org/W2088910177","https://openalex.org/W2090133455","https://openalex.org/W2090601295","https://openalex.org/W2090939668","https://openalex.org/W2093189958","https://openalex.org/W2095582725","https://openalex.org/W2098440133","https://openalex.org/W2100556057","https://openalex.org/W2100846538","https://openalex.org/W2102358242","https://openalex.org/W2105332101","https://openalex.org/W2108214698","https://openalex.org/W2109818577","https://openalex.org/W2112325261","https://openalex.org/W2112484512","https://openalex.org/W2112997651","https://openalex.org/W2114729638","https://openalex.org/W2118841906","https://openalex.org/W2120887338","https://openalex.org/W2126679529","https://openalex.org/W2127567198","https://openalex.org/W2128951033","https://openalex.org/W2136799713","https://openalex.org/W2147462150","https://openalex.org/W2149930945","https://openalex.org/W2158303874","https://openalex.org/W2159054307","https://openalex.org/W2190355996","https://openalex.org/W2246800038","https://openalex.org/W2274671619","https://openalex.org/W2287150761","https://openalex.org/W2408888644","https://openalex.org/W2432952465","https://openalex.org/W2911690791","https://openalex.org/W3125325625","https://openalex.org/W4254311071"],"related_works":["https://openalex.org/W7097925785","https://openalex.org/W1987722108","https://openalex.org/W4409601818","https://openalex.org/W2190355996","https://openalex.org/W2035817290","https://openalex.org/W2025750550","https://openalex.org/W2044295177","https://openalex.org/W2041901223","https://openalex.org/W2094197043","https://openalex.org/W4412363924"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,10,109,177,187],"this":[3],"study":[4],"was":[5,53,74,146],"to":[6,111,115,183,191,204,234],"examine":[7,184],"the":[8,15,185,244],"effects":[9,153,162],"bisphenol":[11],"A":[12],"(BPA)":[13],"on":[14,81,124,163,193,219],"brain":[16,194],"dopamine":[17,82,102],"(DA)":[18],"system":[19],"utilizing":[20],"both":[21,140],"in":[22,64,71,86,101,129,136,179,197,243],"vitro":[23],"models":[24],"(GH3":[25],"cells,":[26,34,66,131],"a":[27,35,68,133,170],"rat":[28],"pituitary":[29],"cell":[30,38,156],"line,":[31],"and":[32,40,142,213],"SH-SY5Y":[33,65,96,130],"human":[36],"neuroblastoma":[37],"line)":[39],"an":[41,99],"animal":[42],"model":[43],"such":[44],"as":[45],"Sprague-Dawley":[46],"(SD)":[47],"rats.":[48],"First,":[49],"cellular":[50],"DA":[51,72,125,195,215,241],"uptake":[52,73],"measured":[54,218],"2":[55,167],"or":[56,92],"8":[57,91],"h":[58,108,176],"following":[59,106,139],"BPA":[60,76,118,150,158,192,205,235],"exposure":[61,110,119,144,178,190,233],"(0.1-400":[62],"\u03bcM)":[63],"where":[67],"significant":[69,134,161],"increase":[70,100],"noted.":[75],"exerted":[77],"no":[78,121,160],"marked":[79,122,171],"effect":[80,123],"active":[83],"transporter":[84,103],"levels":[85,105,128,165,196,216,242],"GH3":[87,137,180],"cells":[88,97,138],"exposed":[89,203],"for":[90],"24":[93,107,175],"h.":[94],"However,":[95],"displayed":[98],"(DAT)":[104],"BPA.":[112],"In":[113],"contrast":[114],"DAT":[116],"levels,":[117],"produced":[120,159],"D1":[126],"receptor":[127],"yet":[132],"decrease":[135],"8-":[141],"24-h":[143],"periods":[145],"noted,":[147],"suggesting":[148],"that":[149,231],"exerts":[151],"differential":[152],"dependent":[154],"upon":[155],"type.":[157],"prolactin":[164],"at":[166,174],"h,":[168],"but":[169],"fall":[172],"occurred":[173],"cells.":[181],"Finally,":[182],"influence":[186],"dietary":[188],"developmental":[189],"F1":[198],"offspring,":[199],"SD":[200,245],"rats":[201],"were":[202,217],"(0.5-20":[206],"mg/kg)":[207],"through":[208],"maternal":[209],"transfer":[210],"and/or":[211],"diet":[212],"striatal":[214,240],"postnatal":[220],"day":[221],"(PND)":[222],"60":[223],"using":[224],"high-performance":[225],"liquid":[226],"chromatography":[227],"(HPLC).":[228],"Data":[229],"demonstrated":[230],"chronic":[232],"did":[236],"not":[237],"significantly":[238],"alter":[239],"rat.":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}