{"id":"https://openalex.org/W2490769112","doi":"https://doi.org/10.1111/hepr.12787","title":"Role of thrombospondin 1 in liver diseases","display_name":"Role of thrombospondin 1 in liver diseases","publication_year":2016,"publication_date":"2016-08-05","ids":{"openalex":"https://openalex.org/W2490769112","doi":"https://doi.org/10.1111/hepr.12787","mag":"2490769112","pmid":"https://pubmed.ncbi.nlm.nih.gov/27492250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292098"},"language":"en","primary_location":{"id":"doi:10.1111/hepr.12787","doi":"https://doi.org/10.1111/hepr.12787","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.12787","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292098","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062332449","display_name":"Yanzhang Li","orcid":"https://orcid.org/0000-0002-7327-0015","observed_orcids":["https://orcid.org/0000-0002-7327-0015"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yanzhang Li","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA","Medical College of Henan University, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Medical College of Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057696393","display_name":"Courtney Turpin","orcid":"https://orcid.org/0000-0001-6299-8062","observed_orcids":["https://orcid.org/0000-0001-6299-8062"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney P. Turpin","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100358482","display_name":"Shuxia Wang","orcid":"https://orcid.org/0000-0003-3102-2117","observed_orcids":["https://orcid.org/0000-0003-3102-2117"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuxia Wang","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100358482"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.4704,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.4546148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"47","issue":"2","first_page":"186","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":1.0},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/matricellular-glycoprotein","display_name":"matricellular glycoprotein","score":0.9160000085830688},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tgf-beta-activation","display_name":"TGF-beta activation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C99194444","wikidata":"https://www.wikidata.org/wiki/Q14906367","display_name":"Thrombospondin 1","level":3,"score":0.8237763047218323},{"id":"https://openalex.org/C2775893135","wikidata":"https://www.wikidata.org/wiki/Q6787792","display_name":"Matricellular protein","level":3,"score":0.6857990026473999},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.6645779013633728},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5646501779556274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.540441632270813},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5231581926345825},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4695601761341095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4531228840351105},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4487544000148773},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4454265832901001},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.43194544315338135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3658488988876343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3566740155220032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3367413878440857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33093202114105225},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2792605459690094},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20537900924682617},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.15573513507843018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10123112797737122},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.0},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1111/hepr.12787","doi":"https://doi.org/10.1111/hepr.12787","is_oa":false,"landing_page_url":"https://doi.org/10.1111/hepr.12787","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:27492250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27492250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5292098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatol Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5292098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatol Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3260898914","display_name":"Upstream Stimulatory Factor 2 regulation of renin in diabetic nephropathy","funder_award_id":"R01DK081555","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3921591931","display_name":"Pharmacology and Nutritional Sciences:  Multidisciplinary Approaches for Metabolic Disease","funder_award_id":"T32DK007778","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4492427055","display_name":"Thrombospondin 1 in obesity associated inflammation and insulin resistance","funder_award_id":"R01DK098176","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W35542602","https://openalex.org/W145549817","https://openalex.org/W233484306","https://openalex.org/W258796069","https://openalex.org/W1549631663","https://openalex.org/W1575754639","https://openalex.org/W1608050470","https://openalex.org/W1839593737","https://openalex.org/W1910153013","https://openalex.org/W1918712426","https://openalex.org/W1970564104","https://openalex.org/W1981516593","https://openalex.org/W1982385780","https://openalex.org/W1986544634","https://openalex.org/W1989905855","https://openalex.org/W1992874803","https://openalex.org/W1993873907","https://openalex.org/W1993967800","https://openalex.org/W1996406153","https://openalex.org/W1997693327","https://openalex.org/W2001602562","https://openalex.org/W2002220495","https://openalex.org/W2002349285","https://openalex.org/W2004329603","https://openalex.org/W2006227076","https://openalex.org/W2009789486","https://openalex.org/W2011019948","https://openalex.org/W2018069344","https://openalex.org/W2022665089","https://openalex.org/W2027069446","https://openalex.org/W2027559978","https://openalex.org/W2028387585","https://openalex.org/W2028886206","https://openalex.org/W2036145193","https://openalex.org/W2036286400","https://openalex.org/W2037627915","https://openalex.org/W2038875372","https://openalex.org/W2040907586","https://openalex.org/W2041374419","https://openalex.org/W2042436980","https://openalex.org/W2042787985","https://openalex.org/W2043103956","https://openalex.org/W2046166693","https://openalex.org/W2046196682","https://openalex.org/W2047318628","https://openalex.org/W2050577046","https://openalex.org/W2051073305","https://openalex.org/W2053264019","https://openalex.org/W2054338888","https://openalex.org/W2054483829","https://openalex.org/W2055843476","https://openalex.org/W2056669173","https://openalex.org/W2060111929","https://openalex.org/W2063211029","https://openalex.org/W2069819211","https://openalex.org/W2072680312","https://openalex.org/W2077062607","https://openalex.org/W2081358537","https://openalex.org/W2081471836","https://openalex.org/W2084089748","https://openalex.org/W2084388684","https://openalex.org/W2085056256","https://openalex.org/W2085675535","https://openalex.org/W2085939705","https://openalex.org/W2089824739","https://openalex.org/W2094457584","https://openalex.org/W2097273361","https://openalex.org/W2099635702","https://openalex.org/W2100156965","https://openalex.org/W2103003178","https://openalex.org/W2104193042","https://openalex.org/W2109878500","https://openalex.org/W2115750968","https://openalex.org/W2118713387","https://openalex.org/W2120335459","https://openalex.org/W2122346650","https://openalex.org/W2124496335","https://openalex.org/W2125075201","https://openalex.org/W2133082274","https://openalex.org/W2134381780","https://openalex.org/W2144814738","https://openalex.org/W2148412726","https://openalex.org/W2149360108","https://openalex.org/W2157518452","https://openalex.org/W2167352445","https://openalex.org/W2229151983","https://openalex.org/W2325818913","https://openalex.org/W2329414459","https://openalex.org/W2405674616","https://openalex.org/W2416779137","https://openalex.org/W2471828796","https://openalex.org/W2515705503","https://openalex.org/W4256132137","https://openalex.org/W7095745927"],"related_works":["https://openalex.org/W6981713030","https://openalex.org/W7071824333","https://openalex.org/W3141679218","https://openalex.org/W2005981463","https://openalex.org/W3092487229","https://openalex.org/W2779950914","https://openalex.org/W2997827971","https://openalex.org/W3016270620","https://openalex.org/W4311930215","https://openalex.org/W2280300527"],"abstract_inverted_index":{"Thrombospondin":[0,59],"1":[1,60],"(TSP1)":[2],"is":[3,61],"a":[4,26],"matricellular":[5],"glycoprotein":[6],"that":[7,93],"can":[8],"be":[9],"secreted":[10],"by":[11],"many":[12,66],"cell":[13,21],"types.":[14],"Through":[15],"binding":[16],"to":[17,40],"extracellular":[18],"proteins":[19],"and/or":[20],"surface":[22],"receptors,":[23],"TSP1":[24,36,73,94],"modulates":[25],"variety":[27],"of":[28,72],"cellular":[29],"functions.":[30,68],"Since":[31],"its":[32],"discovery":[33],"in":[34,44,64,74,96],"1971,":[35],"has":[37,77],"been":[38,79],"found":[39],"play":[41],"important":[42],"roles":[43],"multiple":[45],"biological":[46],"processes":[47],"including":[48],"angiogenesis,":[49],"apoptosis,":[50],"latent":[51],"transforming":[52],"growth":[53],"factor-\u03b2":[54],"activation,":[55],"and":[56,108],"immune":[57],"regulation.":[58],"also":[62],"involved":[63],"regulating":[65],"organ":[67],"However,":[69],"the":[70,87,90],"role":[71,92],"liver":[75,98,104,106],"diseases":[76,99],"not":[78],"extensively":[80],"addressed.":[81],"In":[82],"this":[83],"review,":[84],"we":[85],"summarize":[86],"findings":[88],"about":[89],"possible":[91],"plays":[95],"chronic":[97],"focusing":[100],"on":[101],"non-alcoholic":[102],"fatty":[103],"diseases,":[105],"fibrosis,":[107],"hepatocellular":[109],"carcinoma.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}