{"id":"https://openalex.org/W2490716458","doi":"https://doi.org/10.1002/lt.24514","title":"Favorable longterm outcomes of liver transplant recipients treated de novo with once\u2010daily tacrolimus: Results of a single\u2010center cohort","display_name":"Favorable longterm outcomes of liver transplant recipients treated de novo with once\u2010daily tacrolimus: Results of a single\u2010center cohort","publication_year":2016,"publication_date":"2016-07-19","ids":{"openalex":"https://openalex.org/W2490716458","doi":"https://doi.org/10.1002/lt.24514","mag":"2490716458","pmid":"https://pubmed.ncbi.nlm.nih.gov/27434676"},"language":"en","primary_location":{"id":"doi:10.1002/lt.24514","doi":"https://doi.org/10.1002/lt.24514","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.24514","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039495874","display_name":"Mikel Gastaca","orcid":"https://orcid.org/0000-0003-2771-9640","observed_orcids":["https://orcid.org/0000-0003-2771-9640"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mikel Gastaca","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","University of the Basque Country,Leioa,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]},{"raw_affiliation_string":"University of the Basque Country,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003955605","display_name":"Andr\u00e9s Valdivieso","orcid":"https://orcid.org/0000-0002-2614-3670","observed_orcids":["https://orcid.org/0000-0002-2614-3670"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s Valdivieso","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","University of the Basque Country,Leioa,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]},{"raw_affiliation_string":"University of the Basque Country,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103281246","display_name":"Javier Bustamante","orcid":"https://orcid.org/0000-0002-5280-3038","observed_orcids":["https://orcid.org/0000-0002-5280-3038"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Bustamante","raw_affiliation_strings":["Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","University of the Basque Country,Leioa,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]},{"raw_affiliation_string":"University of the Basque Country,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101461223","display_name":"Jose Ramon Fernandez","orcid":"https://orcid.org/0009-0003-9037-8444","observed_orcids":["https://orcid.org/0009-0003-9037-8444"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 R. Fern\u00e1ndez","raw_affiliation_strings":["Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084227457","display_name":"P. Ru\u00edz","orcid":"https://orcid.org/0000-0002-2598-0370","observed_orcids":["https://orcid.org/0000-0002-2598-0370"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Ruiz","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053602131","display_name":"A. Ventoso","orcid":"https://orcid.org/0000-0003-4635-8545","observed_orcids":["https://orcid.org/0000-0003-4635-8545"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Ventoso","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041489126","display_name":"Milagros Testillano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milagros Testillano","raw_affiliation_strings":["Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059737467","display_name":"Ibone Palomares","orcid":"https://orcid.org/0000-0002-0002-7436","observed_orcids":["https://orcid.org/0000-0002-0002-7436"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ibone Palomares","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102997021","display_name":"Patr\u00edcia Salvador","orcid":"https://orcid.org/0000-0001-7741-9465","observed_orcids":["https://orcid.org/0000-0001-7741-9465"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Salvador","raw_affiliation_strings":["Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025369403","display_name":"Mikel Prieto","orcid":"https://orcid.org/0000-0001-6662-4252","observed_orcids":["https://orcid.org/0000-0001-6662-4252"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mikel Prieto","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110235245","display_name":"Miguel Montejo","orcid":"https://orcid.org/0000-0001-7432-0830","observed_orcids":["https://orcid.org/0000-0001-7432-0830"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Montejo","raw_affiliation_strings":["Infectious Diseases Unit,Cruces University Hospital,Bilbao,Spain","University of the Basque Country,Leioa,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]},{"raw_affiliation_string":"University of the Basque Country,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mar\u00eda J. Su\u00e1rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda J. Su\u00e1rez","raw_affiliation_strings":["Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061040068","display_name":"J. Ortiz de Urbina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jorge Ortiz de Urbina","raw_affiliation_strings":["Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Surgery and Liver Transplantation Unit,Cruces University Hospital,Bilbao,Spain","institution_ids":["https://openalex.org/I4210137412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039495874"],"corresponding_institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210137412"],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":1.9522,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.8418818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"10","first_page":"1391","last_page":"1400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8690000176429749},{"id":"https://openalex.org/keywords/de-novo-immunosuppression","display_name":"de novo immunosuppression","score":0.9670000076293945},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.5720000267028809},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma-recurrence","display_name":"recurrent hepatocellular carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6010000109672546},{"id":"https://openalex.org/keywords/meld-score","display_name":"MELD score","score":0.847000002861023},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9581326246261597},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.8227496147155762},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6168801784515381},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6126663684844971},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6084822416305542},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.5741077661514282},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.5616529583930969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5365678668022156},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5331670045852661},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5182928442955017},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.5178545117378235},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5012333393096924},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46855172514915466},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4635791778564453},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4452459216117859},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43805167078971863},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.43229392170906067},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10717299580574036}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058625","descriptor_name":"End Stage Liver Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/lt.24514","doi":"https://doi.org/10.1002/lt.24514","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.24514","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:27434676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27434676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1487829840","https://openalex.org/W1536023299","https://openalex.org/W1557067957","https://openalex.org/W1571499040","https://openalex.org/W1577923989","https://openalex.org/W1588296982","https://openalex.org/W1589052334","https://openalex.org/W1592892624","https://openalex.org/W1810588768","https://openalex.org/W1914876920","https://openalex.org/W1922139510","https://openalex.org/W1944288770","https://openalex.org/W1964040862","https://openalex.org/W1972836721","https://openalex.org/W1976082980","https://openalex.org/W1978925494","https://openalex.org/W1992836566","https://openalex.org/W1996210189","https://openalex.org/W1996468254","https://openalex.org/W2003688556","https://openalex.org/W2006421890","https://openalex.org/W2013904531","https://openalex.org/W2015702174","https://openalex.org/W2016435159","https://openalex.org/W2027992390","https://openalex.org/W2028851899","https://openalex.org/W2031144597","https://openalex.org/W2042450295","https://openalex.org/W2043575472","https://openalex.org/W2079649533","https://openalex.org/W2088136673","https://openalex.org/W2115880608","https://openalex.org/W2130106335","https://openalex.org/W2134554934","https://openalex.org/W2134672034","https://openalex.org/W2153224292","https://openalex.org/W2163721979","https://openalex.org/W2170739720","https://openalex.org/W2173253647","https://openalex.org/W2315717341","https://openalex.org/W2403228686","https://openalex.org/W4246823671"],"related_works":["https://openalex.org/W2747182728","https://openalex.org/W1996210189","https://openalex.org/W2326775418","https://openalex.org/W2970088902","https://openalex.org/W3013839706","https://openalex.org/W2331166560","https://openalex.org/W4386116389","https://openalex.org/W2068572841","https://openalex.org/W2006421890","https://openalex.org/W2973453908"],"abstract_inverted_index":{"The":[0,59,124,137],"once-daily":[1,54,241],"prolonged-release":[2],"formulation":[3],"of":[4,42,46,63,76,134,140,176,186,213],"tacrolimus":[5,55,107,242],"has":[6],"been":[7],"recently":[8],"related":[9],"with":[10,53,68,72,131,169,215,259],"significant":[11],"graft":[12],"and":[13,29,145,150,202,208,252],"patient":[14],"mid-term":[15],"survival":[16,198,212,255],"advantages;":[17],"however,":[18],"practical":[19],"information":[20],"on":[21,238],"the":[22,90,102,164],"de":[23,51,141,239],"novo":[24,52,142,240],"administration":[25],"after":[26,94,101,163,167],"liver":[27,47],"transplantation":[28],"longterm":[30,254],"outcomes":[31,251],"is":[32,37,243],"currently":[33],"lacking.":[34],"This":[35],"study":[36,60,233],"a":[38,43,73,170],"5-year":[39],"retrospective":[40],"analysis":[41],"single-center":[44],"cohort":[45,61],"transplant":[48,168],"recipients":[49],"treated":[50],"(April":[56],"2008/August":[57],"2011).":[58],"consisted":[62],"160":[64],"patients,":[65],"including":[66],"23":[67],"pretransplant":[69],"renal":[70,119],"dysfunction,":[71],"median":[74],"follow-up":[75],"57.6":[77],"months":[78,93],"(interquartile":[79],"range,":[80],"46.6-69.0).":[81],"Tacrolimus":[82],"target":[83],"trough":[84],"levels":[85],"were":[86,147],"5-10":[87],"ng/mL":[88,100],"during":[89,114],"first":[91,103],"3":[92],"transplant,":[95],"reducing":[96],"progressively":[97],"to":[98,118],"<7":[99],"posttransplant":[104],"year.":[105],"Once-daily":[106],"was":[108,129,157,205,226],"withdrawn":[109],"in":[110,245,257],"35":[111],"(21.8%)":[112],"patients":[113,188,214,258],"follow-up,":[115],"mostly":[116],"due":[117],"dysfunction":[120],"and/or":[121],"metabolic":[122],"syndrome.":[123],"biopsy-proven":[125],"acute":[126],"rejection":[127],"rate":[128,156,175],"12.5%":[130],"no":[132],"cases":[133],"steroid-resistant":[135],"rejection.":[136],"cumulative":[138],"incidence":[139],"diabetes,":[143],"hypertension,":[144],"dyslipidemia":[146],"16.9%,":[148],"31.2%,":[149],"6.5%,":[151],"respectively.":[152,210],"Hepatocellular":[153],"carcinoma":[154],"recurrence":[155],"2.8%.":[158],"Renal":[159],"function":[160],"remained":[161],"stable":[162],"sixth":[165],"month":[166],"mean":[171],"estimated":[172],"glomerular":[173],"filtration":[174],"77.7":[177],"\u00b1":[178],"19.6":[179],"mL/minute/1.73":[180],"m(2)":[181],"at":[182,199],"5":[183,203],"years.":[184],"None":[185],"our":[187,232],"developed":[189],"chronic":[190],"kidney":[191],"disease":[192],"stage":[193],"4":[194],"or":[195],"5.":[196],"Patient":[197],"1,":[200],"3,":[201],"years":[204],"96.3%,":[206],"91.9%,":[207],"88.3%,":[209],"Overall":[211],"Model":[216],"for":[217],"End-Stage":[218],"Liver":[219,263],"Disease":[220],"(MELD)":[221],"score":[222],">":[223],"25":[224],"points":[225],"not":[227],"significantly":[228],"different.":[229],"In":[230],"conclusion,":[231],"suggests":[234],"that":[235],"immunosuppression":[236],"based":[237],"feasible":[244],"routine":[246],"clinical":[247],"practice,":[248],"showing":[249],"favorable":[250],"outstanding":[253],"even":[256],"high":[260],"MELD":[261],"scores.":[262],"Transplantation":[264],"22":[265],"1391-1400":[266],"2016":[267],"AASLD.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}