{"id":"https://openalex.org/W2490590760","doi":"https://doi.org/10.1158/1538-7445.am2016-4222","title":"Abstract 4222: Usefulness of VE1 immunohistochemical detection of BRAFV600E in aggressive thyroid cancers (PDCs and UCs)","display_name":"Abstract 4222: Usefulness of VE1 immunohistochemical detection of BRAFV600E in aggressive thyroid cancers (PDCs and UCs)","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2490590760","doi":"https://doi.org/10.1158/1538-7445.am2016-4222","mag":"2490590760"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-4222","doi":"https://doi.org/10.1158/1538-7445.am2016-4222","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4222","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015391583","display_name":"Noa Fe\u00e1s-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5212-916X","observed_orcids":["https://orcid.org/0000-0002-5212-916X"]},"institutions":[{"id":"https://openalex.org/I4210141160","display_name":"Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid","ror":"https://ror.org/03kjyy960","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I134820265","https://openalex.org/I4210141160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noa Fe\u00e1s-Rodr\u00edguez","raw_affiliation_strings":["1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;","institution_ids":["https://openalex.org/I4210141160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009992641","display_name":"\u00c2ngela M. Costa","orcid":"https://orcid.org/0000-0002-8911-1043","observed_orcids":["https://orcid.org/0000-0002-8911-1043"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Angela M. Costa","raw_affiliation_strings":["2Universidade do Minho, Braga, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universidade do Minho, Braga, Portugal;","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021424751","display_name":"Tom\u00e1s Alvarez Gago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tom\u00e1s Alvarez Gago","raw_affiliation_strings":["3Department of Pathology - School of Medicine - Valladolid University, Valladolid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology - School of Medicine - Valladolid University, Valladolid, Spain;","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040076553","display_name":"Juan Jos\u00e9 Mateos Otero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Jos\u00e9 Mateos Otero","raw_affiliation_strings":["3Department of Pathology - School of Medicine - Valladolid University, Valladolid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology - School of Medicine - Valladolid University, Valladolid, Spain;","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110321603","display_name":"Jos\u00e9 Manuel Cameselle Teijeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Manuel Cameselle Teijeiro","raw_affiliation_strings":["4Department of Pathology, Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010868256","display_name":"Raquel Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-1207-6275","observed_orcids":["https://orcid.org/0000-0003-1207-6275"]},"institutions":[{"id":"https://openalex.org/I4210141160","display_name":"Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid","ror":"https://ror.org/03kjyy960","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I134820265","https://openalex.org/I4210141160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Mu\u00f1oz","raw_affiliation_strings":["1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;","institution_ids":["https://openalex.org/I4210141160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105892128","display_name":"Ginesa Garc\u00eda\u2010Rost\u00e1n","orcid":"https://orcid.org/0000-0002-9238-1263","observed_orcids":["https://orcid.org/0000-0002-9238-1263"]},"institutions":[{"id":"https://openalex.org/I4210141160","display_name":"Instituto de Biomedicina y Gen\u00e9tica Molecular de Valladolid","ror":"https://ror.org/03kjyy960","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I134820265","https://openalex.org/I4210141160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ginesa Maria Garcia-Rostan","raw_affiliation_strings":["1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Molecular Biology and Genetics (IBGM), Valladolid, Spain;","institution_ids":["https://openalex.org/I4210141160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"4222","last_page":"4222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ve1-antibody","display_name":"VE1 antibody","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immunohistochemical-detection","display_name":"immunohistochemical detection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/poorly-differentiated-thyroid-carcinoma","display_name":"poorly differentiated thyroid carcinoma","score":0.796999990940094},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/aggressive-thyroid-cancer","display_name":"aggressive thyroid cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.5979999899864197},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.6349999904632568},{"id":"https://openalex.org/keywords/follicular-carcinoma","display_name":"follicular carcinoma","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7178121209144592},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6366132497787476},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6139183044433594},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5233913064002991},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.49602946639060974},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4823321998119354},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.4734111428260803},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4689241051673889},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.4598136842250824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43772000074386597},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4359711706638336},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4195898771286011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41773489117622375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3803441822528839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32621505856513977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12472185492515564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11437004804611206}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-4222","doi":"https://doi.org/10.1158/1538-7445.am2016-4222","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4222","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061202097","https://openalex.org/W2328822668","https://openalex.org/W3043699476","https://openalex.org/W4386793095","https://openalex.org/W1496324633","https://openalex.org/W2417034177","https://openalex.org/W4235546429","https://openalex.org/W3009094826","https://openalex.org/W1919269372","https://openalex.org/W2238562388"],"abstract_inverted_index":{"Abstract":[0],"Activating":[1],"BRAF":[2,65,102,141,166,203],"mutations":[3,167,247],"are":[4,77],"frequent":[5],"in":[6,21,74,84,117,145,168,178,202,217,248,259,294],"thyroid":[7,24,48,89,151,296],"follicular":[8],"cell":[9],"carcinogenesis.":[10],"The":[11,173,199],"BRAFV600E":[12,34,115,174,245,293],"point":[13,246],"mutation":[14,35,116,175],"represents":[15],"the":[16,33,64,98,114,132,135,140,163,224,241,305,310],"most":[17],"common":[18],"oncogenic":[19],"event":[20],"sporadic":[22],"papillary":[23],"cancer":[25,49],"(PTC).":[26],"Although":[27],"at":[28],"a":[29,109,118,146],"much":[30],"lower":[31],"frequency":[32],"is":[36],"also":[37],"present":[38,177],"among":[39],"less":[40],"differentiated,":[41],"more":[42],"aggressive,":[43],"I131":[44,87],"resistant":[45,88],"forms":[46],"of":[47,134,148,165,244,288,292,304,309],"as":[50],"poorly":[51],"differentiated":[52],"carcinomas":[53,57],"(PDCs)":[54],"and":[55,155,171,182,193,220,299],"undifferentiated":[56],"(UCs).":[58],"Small":[59],"molecule":[60],"inhibitors":[61],"targeting":[62],"either":[63],"V600E":[66,103,142,204],"protein":[67,144],"or":[68,70,81],"upstream":[69],"downstream":[71],"kinases":[72],"involved":[73],"MAPK":[75],"signalling":[76],"currently":[78],"under":[79],"pre-clinical":[80],"clinical":[82,119,249],"investigation":[83],"advanced,":[85],"metastatic,":[86],"cancers.":[90],"Recently,":[91],"immunohistochemical":[92,290],"(IHC)":[93],"studies":[94],"on":[95],"PTCs,":[96],"using":[97],"VE1":[99,136,230,289],"mouse":[100],"anti-human":[101],"antibody":[104,137,231],"have":[105],"shown":[106],"to":[107,130,210,236],"be":[108,233],"reliable":[110],"means":[111],"for":[112,138,162,240,313],"detecting":[113,139],"setting":[120],"without":[121,251],"molecular":[122,237,252],"genotyping":[123,253],"units.":[124],"In":[125],"this":[126],"study":[127],"we":[128],"sought":[129],"determine":[131],"usefulness":[133],"mutant":[143],"series":[147],"103":[149],"aggressive":[150,295],"cancers":[152,297],"(59":[153],"PDCs":[154,180,190,219],"44":[156],"UCs)":[157],"previously":[158],"characterized":[159],"by":[160],"PCR-SSCP":[161],"presence":[164],"exons":[169],"11":[170],"15.":[172],"was":[176],"10/59":[179],"(17%)":[181],"11/44":[183],"UCs":[184,196],"(25%).":[185],"Immunohistochemistry":[186],"revealed":[187],"9":[188,194],"mutated":[189,195,205],"(sensitivity":[191],"90%)":[192],"(82%":[197],"sensitivity).":[198],"staining":[200],"intensity":[201],"samples":[206],"ranged":[207],"from":[208],"weak":[209],"strong.":[211],"Non":[212],"valuable":[213],"results":[214,225],"were":[215],"found":[216],"3":[218],"4":[221],"UCs.":[222],"Overall":[223],"indicate":[226],"that":[227],"immunohistochemistry":[228],"with":[229],"may":[232,256],"an":[234],"alternative":[235],"biology":[238],"approaches":[239],"routine":[242],"detection":[243,291],"settings":[250],"facilities.":[254],"It":[255],"help":[257],"clinicians":[258],"targeted":[260],"therapy":[261],"decision":[262],"making.":[263],"Citation":[264],"Format:":[265],"Noa":[266],"Fe\u00e1s-Rodr\u00edguez,":[267],"Angela":[268],"M.":[269],"Costa,":[270],"Tom\u00e1s":[271],"Alvarez":[272],"Gago,":[273],"Juan":[274],"Jos\u00e9":[275],"Mateos":[276],"Otero,":[277],"Jose":[278],"Manuel":[279],"Cameselle":[280],"Teijeiro,":[281],"Raquel":[282],"Mu\u00f1oz,":[283],"Ginesa":[284],"Maria":[285],"Garcia-Rostan.":[286],"Usefulness":[287],"(PDCs":[298],"UCs).":[300],"[abstract].":[301],"In:":[302],"Proceedings":[303],"107th":[306],"Annual":[307],"Meeting":[308],"American":[311],"Association":[312],"Cancer":[314,325],"Research;":[315],"2016":[316],"Apr":[317],"16-20;":[318],"New":[319],"Orleans,":[320],"LA.":[321],"Philadelphia":[322],"(PA):":[323],"AACR;":[324],"Res":[326],"2016;76(14":[327],"Suppl):Abstract":[328],"nr":[329],"4222.":[330]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-08-23T00:00:00"}
