{"id":"https://openalex.org/W2490415147","doi":null,"title":"Review Article High-grade Prostatic Intraepithelial Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer","display_name":"Review Article High-grade Prostatic Intraepithelial Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2490415147","mag":"2490415147"},"language":"en","primary_location":{"id":"mag:2490415147","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Debra_Zynger/publication/23807574_High-grade_Prostatic_Intraepithelial_Neoplasia_of_the_Prostate_The_Precursor_Lesion_of_Prostate_Cancer/links/00b49533f0ceea6614000000.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029140080","display_name":"Debra L. Zynger","orcid":"https://orcid.org/0000-0003-1038-5699","observed_orcids":["https://orcid.org/0000-0003-1038-5699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra L. Zynger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1038-5699","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080276829","display_name":"Ximing J. Yang","orcid":"https://orcid.org/0000-0002-3370-6208","observed_orcids":["https://orcid.org/0000-0002-3370-6208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ximing J. Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3370-6208","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44061909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-prostatic-intraepithelial-neoplasia","display_name":"high-grade prostatic intraepithelial neoplasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.8130000233650208},{"id":"https://openalex.org/keywords/precursor-lesions","display_name":"precursor lesions","score":0.8700000047683716},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.9279999732971191},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.550000011920929},{"id":"https://openalex.org/keywords/histopathological-terminology","display_name":"histopathological terminology","score":0.6259999871253967},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.6499999761581421},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.625},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2776456063","wikidata":"https://www.wikidata.org/wiki/Q15731388","display_name":"High-grade prostatic intraepithelial neoplasia","level":5,"score":0.9361606240272522},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.8353241682052612},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7619600892066956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7150838971138},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6271641254425049},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.549115777015686},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5259979963302612},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5205058455467224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5156821012496948},{"id":"https://openalex.org/C2910254342","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostatic adenocarcinoma","level":4,"score":0.48925209045410156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21334514021873474}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2490415147","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Debra_Zynger/publication/23807574_High-grade_Prostatic_Intraepithelial_Neoplasia_of_the_Prostate_The_Precursor_Lesion_of_Prostate_Cancer/links/00b49533f0ceea6614000000.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W143865549","https://openalex.org/W1541480589","https://openalex.org/W1567559129","https://openalex.org/W1966588816","https://openalex.org/W1966903123","https://openalex.org/W1968149100","https://openalex.org/W1972309806","https://openalex.org/W1975270142","https://openalex.org/W1975537057","https://openalex.org/W1976248247","https://openalex.org/W1977270838","https://openalex.org/W1982557914","https://openalex.org/W1983690106","https://openalex.org/W1988913944","https://openalex.org/W1989764260","https://openalex.org/W1996388835","https://openalex.org/W2000505029","https://openalex.org/W2002471362","https://openalex.org/W2006190057","https://openalex.org/W2008351527","https://openalex.org/W2009948823","https://openalex.org/W2010424792","https://openalex.org/W2016469823","https://openalex.org/W2017027982","https://openalex.org/W2018596412","https://openalex.org/W2022550871","https://openalex.org/W2024850963","https://openalex.org/W2025445728","https://openalex.org/W2032015123","https://openalex.org/W2035121472","https://openalex.org/W2037256429","https://openalex.org/W2038651116","https://openalex.org/W2048228831","https://openalex.org/W2053079199","https://openalex.org/W2056963048","https://openalex.org/W2057647147","https://openalex.org/W2057991385","https://openalex.org/W2058009055","https://openalex.org/W2062987072","https://openalex.org/W2063023403","https://openalex.org/W2064698733","https://openalex.org/W2068825839","https://openalex.org/W2073232639","https://openalex.org/W2073374971","https://openalex.org/W2075745394","https://openalex.org/W2082970232","https://openalex.org/W2083504451","https://openalex.org/W2083700769","https://openalex.org/W2084197013","https://openalex.org/W2086284944","https://openalex.org/W2090526822","https://openalex.org/W2094746535","https://openalex.org/W2095051112","https://openalex.org/W2096071102","https://openalex.org/W2107474944","https://openalex.org/W2107484695","https://openalex.org/W2116732170","https://openalex.org/W2128536507","https://openalex.org/W2136282053","https://openalex.org/W2140417252","https://openalex.org/W2150242610","https://openalex.org/W2155836844","https://openalex.org/W2157395875","https://openalex.org/W2159280763","https://openalex.org/W2164777007","https://openalex.org/W2314503228","https://openalex.org/W2314608765","https://openalex.org/W2333795406","https://openalex.org/W2395650506","https://openalex.org/W2400036618","https://openalex.org/W2402691722","https://openalex.org/W2411381171","https://openalex.org/W2414542109","https://openalex.org/W2422074834","https://openalex.org/W2425408989","https://openalex.org/W2466752807","https://openalex.org/W2887478824"],"related_works":["https://openalex.org/W1506654624","https://openalex.org/W1776891179","https://openalex.org/W1979008650","https://openalex.org/W2100026206","https://openalex.org/W2086474306","https://openalex.org/W2185049322","https://openalex.org/W2410957605","https://openalex.org/W2790525703","https://openalex.org/W2026042188","https://openalex.org/W2074712672"],"abstract_inverted_index":{"High-grade":[0],"intraepithelial":[1],"neoplasia":[2],"(HGPIN)":[3],"is":[4,8,41,54,62],"a":[5,13,42],"lesion":[6,44],"which":[7],"widely":[9],"believed":[10],"to":[11,50,64],"be":[12],"precursor":[14],"of":[15,21,26,97],"prostatic":[16,71],"adenocarcinoma.":[17],"Correct":[18],"morphologic":[19],"identification":[20],"HGPIN":[22,40],"and":[23,70,76,90,94],"an":[24],"understanding":[25],"how":[27],"this":[28,98],"diagnosis":[29],"affects":[30],"clinical":[31,93],"management":[32],"in":[33,87],"the":[34,84,92],"research":[35,95],"setting":[36],"are":[37],"necessary":[38],"as":[39],"premalignant":[43],"with":[45],"many":[46],"genetic":[47],"alterations":[48],"similar":[49],"prostate":[51],"cancer,":[52],"but":[53],"not":[55],"yet":[56],"invasive":[57],"cancer.":[58],"As":[59],"such":[60],"it":[61],"critical":[63],"differentiate":[65],"between":[66],"benign":[67],"entities,":[68],"HGPIN,":[69,82],"adenocarcinoma":[72],"for":[73],"experimental":[74],"design":[75],"data":[77],"interpretation.":[78],"This":[79],"review":[80],"discusses":[81],"clarifies":[83],"terminology":[85],"used":[86],"pathology":[88],"reports,":[89],"describes":[91],"implications":[96],"entity.":[99]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-08-23T00:00:00"}
