{"id":"https://openalex.org/W2489964486","doi":null,"title":"Genetic factors and immune responses in chronic infectious diseases","display_name":"Genetic factors and immune responses in chronic infectious diseases","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2489964486","mag":"2489964486"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:publications/6c3702b8-1cc0-4708-b8c5-98eebbbf3ea2","doi":null,"is_oa":false,"landing_page_url":"http://research-repository.uwa.edu.au/en/publications/genetic-factors-and-immune-responses-in-chronic-infectious-diseases(6c3702b8-1cc0-4708-b8c5-98eebbbf3ea2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Affandi, J 2014, 'Genetic factors and immune responses in chronic infectious diseases', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045844277","display_name":"Jacquita S. Affandi","orcid":"https://orcid.org/0000-0003-0095-3808","observed_orcids":["https://orcid.org/0000-0003-0095-3808"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacquita S. Affandi","raw_affiliation_strings":["School of Pathology and Laboratory Medicine"],"raw_orcid":"https://orcid.org/0000-0003-0095-3808","affiliations":[{"raw_affiliation_string":"School of Pathology and Laboratory Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045844277"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-infectious-diseases","display_name":"chronic infectious diseases","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.7229999899864197},{"id":"https://openalex.org/keywords/nontuberculous-mycobacterial-infection","display_name":"nontuberculous mycobacterial infection","score":0.968999981880188},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6570000052452087},{"id":"https://openalex.org/keywords/slc11a1","display_name":"SLC11A1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.7670000195503235},{"id":"https://openalex.org/keywords/il28b","display_name":"IL28B","score":0.9269999861717224},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8510000109672546},{"id":"https://openalex.org/keywords/il12b","display_name":"IL12B","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lilrb1","display_name":"LILRB1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/duffy-antigen-receptor-for-chemokines","display_name":"DARC","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cd4-nadir","display_name":"CD4 nadir","score":0.5609999895095825},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.578000009059906},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.8025263547897339},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6148008108139038},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.509320855140686},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4949018359184265},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4824815094470978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3790256977081299},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3769124448299408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3731474280357361},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33888429403305054},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2976381778717041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08919849991798401}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:publications/6c3702b8-1cc0-4708-b8c5-98eebbbf3ea2","doi":null,"is_oa":false,"landing_page_url":"http://research-repository.uwa.edu.au/en/publications/genetic-factors-and-immune-responses-in-chronic-infectious-diseases(6c3702b8-1cc0-4708-b8c5-98eebbbf3ea2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Affandi, J 2014, 'Genetic factors and immune responses in chronic infectious diseases', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2489964486","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/files/9254455/Affandi_Jacquita_2014.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":285,"referenced_works":["https://openalex.org/W32276353","https://openalex.org/W144007480","https://openalex.org/W178986790","https://openalex.org/W196022312","https://openalex.org/W1433281043","https://openalex.org/W1481608537","https://openalex.org/W1499666021","https://openalex.org/W1504603444","https://openalex.org/W1515527087","https://openalex.org/W1537845978","https://openalex.org/W1553612782","https://openalex.org/W1566992315","https://openalex.org/W1572477612","https://openalex.org/W1573416472","https://openalex.org/W1573940138","https://openalex.org/W1580745269","https://openalex.org/W1581280637","https://openalex.org/W1586373845","https://openalex.org/W1593105372","https://openalex.org/W1596604198","https://openalex.org/W1642902238","https://openalex.org/W1653338534","https://openalex.org/W1801771134","https://openalex.org/W1841846581","https://openalex.org/W1846859917","https://openalex.org/W1885912605","https://openalex.org/W1926318882","https://openalex.org/W1952396981","https://openalex.org/W1963542699","https://openalex.org/W1965351429","https://openalex.org/W1965545275","https://openalex.org/W1968009444","https://openalex.org/W1968394032","https://openalex.org/W1968700121","https://openalex.org/W1968762621","https://openalex.org/W1969814796","https://openalex.org/W1970910747","https://openalex.org/W1972154492","https://openalex.org/W1972593680","https://openalex.org/W1973094787","https://openalex.org/W1973425803","https://openalex.org/W1974898639","https://openalex.org/W1975217762","https://openalex.org/W1975388230","https://openalex.org/W1975576166","https://openalex.org/W1977297992","https://openalex.org/W1977298614","https://openalex.org/W1979263379","https://openalex.org/W1980882260","https://openalex.org/W1982922581","https://openalex.org/W1983035283","https://openalex.org/W1983918159","https://openalex.org/W1984165284","https://openalex.org/W1984186890","https://openalex.org/W1986151024","https://openalex.org/W1986269363","https://openalex.org/W1987757737","https://openalex.org/W1989550920","https://openalex.org/W1989832114","https://openalex.org/W1990130369","https://openalex.org/W1990517471","https://openalex.org/W1993363703","https://openalex.org/W1994042805","https://openalex.org/W1994297698","https://openalex.org/W1994861742","https://openalex.org/W1995001296","https://openalex.org/W1995310850","https://openalex.org/W1995326684","https://openalex.org/W1995702224","https://openalex.org/W1995905907","https://openalex.org/W1996453015","https://openalex.org/W1996573346","https://openalex.org/W1997017549","https://openalex.org/W1997029919","https://openalex.org/W1998055077","https://openalex.org/W1998793192","https://openalex.org/W1998968163","https://openalex.org/W2000899720","https://openalex.org/W2001074568","https://openalex.org/W2001904357","https://openalex.org/W2001908390","https://openalex.org/W2002863111","https://openalex.org/W2003025881","https://openalex.org/W2003781539","https://openalex.org/W2003803349","https://openalex.org/W2005865250","https://openalex.org/W2006564022","https://openalex.org/W2006619058","https://openalex.org/W2008221423","https://openalex.org/W2008275485","https://openalex.org/W2008341098","https://openalex.org/W2009219530","https://openalex.org/W2011490846","https://openalex.org/W2011647946","https://openalex.org/W2011703513","https://openalex.org/W2011846108","https://openalex.org/W2012178682","https://openalex.org/W2012872735","https://openalex.org/W2013038545","https://openalex.org/W2013202517","https://openalex.org/W2013721785","https://openalex.org/W2013948033","https://openalex.org/W2016821205","https://openalex.org/W2016884510","https://openalex.org/W2017013905","https://openalex.org/W2018990797","https://openalex.org/W2019628365","https://openalex.org/W2019636581","https://openalex.org/W2020627902","https://openalex.org/W2020663635","https://openalex.org/W2020931454","https://openalex.org/W2021274912","https://openalex.org/W2022069273","https://openalex.org/W2022547541","https://openalex.org/W2026614040","https://openalex.org/W2027744251","https://openalex.org/W2028200430","https://openalex.org/W2028281335","https://openalex.org/W2028445837","https://openalex.org/W2031467894","https://openalex.org/W2032253670","https://openalex.org/W2034457488","https://openalex.org/W2037306042","https://openalex.org/W2042689457","https://openalex.org/W2043112537","https://openalex.org/W2043509121","https://openalex.org/W2045506628","https://openalex.org/W2045525130","https://openalex.org/W2046503851","https://openalex.org/W2047004556","https://openalex.org/W2049168557","https://openalex.org/W2049441347","https://openalex.org/W2049693838","https://openalex.org/W2050373436","https://openalex.org/W2050752994","https://openalex.org/W2051682683","https://openalex.org/W2051848905","https://openalex.org/W2051890542","https://openalex.org/W2051948527","https://openalex.org/W2052806181","https://openalex.org/W2053136658","https://openalex.org/W2053222482","https://openalex.org/W2053267305","https://openalex.org/W2054089691","https://openalex.org/W2057122918","https://openalex.org/W2057597640","https://openalex.org/W2057991224","https://openalex.org/W2058855972","https://openalex.org/W2059076093","https://openalex.org/W2059279448","https://openalex.org/W2060152991","https://openalex.org/W2060452011","https://openalex.org/W2061441324","https://openalex.org/W2061542205","https://openalex.org/W2062415421","https://openalex.org/W2065431282","https://openalex.org/W2065461284","https://openalex.org/W2065859456","https://openalex.org/W2066368170","https://openalex.org/W2068665787","https://openalex.org/W2071843907","https://openalex.org/W2071917546","https://openalex.org/W2073126348","https://openalex.org/W2073555741","https://openalex.org/W2073739597","https://openalex.org/W2073775908","https://openalex.org/W2075464412","https://openalex.org/W2077566619","https://openalex.org/W2078082844","https://openalex.org/W2079641738","https://openalex.org/W2080495121","https://openalex.org/W2080763651","https://openalex.org/W2081208716","https://openalex.org/W2081385027","https://openalex.org/W2082666033","https://openalex.org/W2082734149","https://openalex.org/W2084417526","https://openalex.org/W2085941287","https://openalex.org/W2086660485","https://openalex.org/W2086751610","https://openalex.org/W2087183134","https://openalex.org/W2087924325","https://openalex.org/W2088975602","https://openalex.org/W2089157910","https://openalex.org/W2089196954","https://openalex.org/W2091853764","https://openalex.org/W2091969520","https://openalex.org/W2093043725","https://openalex.org/W2093910320","https://openalex.org/W2094945945","https://openalex.org/W2095242874","https://openalex.org/W2098892972","https://openalex.org/W2102222726","https://openalex.org/W2102792164","https://openalex.org/W2102849529","https://openalex.org/W2103824932","https://openalex.org/W2104372421","https://openalex.org/W2105058357","https://openalex.org/W2105896776","https://openalex.org/W2105928329","https://openalex.org/W2107674270","https://openalex.org/W2109152623","https://openalex.org/W2109299306","https://openalex.org/W2110076538","https://openalex.org/W2110307548","https://openalex.org/W2112223832","https://openalex.org/W2113395588","https://openalex.org/W2113865694","https://openalex.org/W2113919049","https://openalex.org/W2115027745","https://openalex.org/W2115364134","https://openalex.org/W2117162099","https://openalex.org/W2118232055","https://openalex.org/W2118512649","https://openalex.org/W2118598122","https://openalex.org/W2119574025","https://openalex.org/W2122138110","https://openalex.org/W2122363276","https://openalex.org/W2126121962","https://openalex.org/W2127923195","https://openalex.org/W2129195110","https://openalex.org/W2129259763","https://openalex.org/W2129786694","https://openalex.org/W2130733240","https://openalex.org/W2132990407","https://openalex.org/W2133707412","https://openalex.org/W2133851198","https://openalex.org/W2134785638","https://openalex.org/W2138056290","https://openalex.org/W2138694347","https://openalex.org/W2140883547","https://openalex.org/W2141946660","https://openalex.org/W2142073962","https://openalex.org/W2142400001","https://openalex.org/W2142447693","https://openalex.org/W2142837562","https://openalex.org/W2143970440","https://openalex.org/W2143998769","https://openalex.org/W2145676989","https://openalex.org/W2145788769","https://openalex.org/W2146074863","https://openalex.org/W2146614605","https://openalex.org/W2148199040","https://openalex.org/W2148200023","https://openalex.org/W2149370934","https://openalex.org/W2149657835","https://openalex.org/W2150683218","https://openalex.org/W2151846965","https://openalex.org/W2152320056","https://openalex.org/W2152906249","https://openalex.org/W2153331359","https://openalex.org/W2153837446","https://openalex.org/W2154615072","https://openalex.org/W2156236127","https://openalex.org/W2156872221","https://openalex.org/W2158966732","https://openalex.org/W2159472638","https://openalex.org/W2161911625","https://openalex.org/W2162600813","https://openalex.org/W2162694378","https://openalex.org/W2162876988","https://openalex.org/W2163257313","https://openalex.org/W2164575308","https://openalex.org/W2164761140","https://openalex.org/W2165199161","https://openalex.org/W2165886134","https://openalex.org/W2166920368","https://openalex.org/W2167772460","https://openalex.org/W2169122057","https://openalex.org/W2170708302","https://openalex.org/W2171429463","https://openalex.org/W2175071274","https://openalex.org/W2232244175","https://openalex.org/W2235110726","https://openalex.org/W2319172453","https://openalex.org/W2327282327","https://openalex.org/W2328746135","https://openalex.org/W2334921349","https://openalex.org/W2399462843","https://openalex.org/W2407697845","https://openalex.org/W2413447174","https://openalex.org/W2418884700","https://openalex.org/W3010865675","https://openalex.org/W3143755808","https://openalex.org/W4236376552"],"related_works":["https://openalex.org/W4246053769","https://openalex.org/W2145788769","https://openalex.org/W7128501979","https://openalex.org/W2005038327","https://openalex.org/W2955367787","https://openalex.org/W7099127908","https://openalex.org/W7161769932","https://openalex.org/W3184168716","https://openalex.org/W2046478473","https://openalex.org/W3207543270"],"abstract_inverted_index":{"The":[0],"outcome":[1],"and":[2,11,39,57,63,104,149,169,202,242,261,267,272,295,334,346,412,472,501,546,550,576,591,607],"prognosis":[3],"of":[4,26,98,147,166,217,280,325,338,341,353,401,416,441,504,524,548,552,566,573,587,622,647],"chronic":[5],"infectious":[6],"diseases":[7],"often":[8,64],"involves":[9],"genetic":[10,80,92,585],"immunological":[12],"mechanisms":[13],"which":[14,490],"may":[15,650],"predict":[16,178],"susceptibility":[17,110,138,179,237,588],"to":[18,73,85,111,139,156,180,182,238,395,478,492,625],"the":[19,24,99,135,154,170,339,442,468,493,521,567,581,628,636,645],"underlying":[20],"infection":[21],"or":[22,89,377],"affect":[23],"consequences":[25],"infection.":[27],"Here":[28],"I":[29,78,173],"focus":[30],"my":[31],"investigations":[32],"on":[33,359,387,456,520,531],"tuberculosis":[34],"immune":[35,113,344,487,499,522,568],"restoration":[36,114],"disease":[37,42,54,67,115],"(TB-IRD)":[38],"cytomegalovirus":[40],"(CMV)":[41],"in":[43,102,117,130,186,189,251,264,298,350,381,410,424,536,589,614,635],"patients":[44,120,188,197,227,290,355,383,411,526],"with":[45,109,122,137,145,163,207,235,277,302,314,323,366,374,414,453,465,497],"human":[46],"immunodeficiency":[47],"virus":[48],"(HIV)":[49],"disease.":[50,209,284,593],"Non-tuberculous":[51],"mycobacterial":[52,590],"(NTM)":[53],"is":[55,69],"clinically":[56],"radiographically":[58],"indistinguishable":[59],"from":[60,87,225],"TB":[61,88,187],"diagnosis":[62,68],"overlooked.":[65],"NTM":[66,196,208,226],"rising":[70],"worldwide":[71],"due":[72],"better":[74],"laboratory":[75],"identification,":[76],"hence":[77],"explored":[79,349],"markers":[81,337,586,600],"as":[82,583,602],"another":[83],"approach":[84],"distinguish":[86],"if":[90],"similar":[91,491],"observations":[93,512],"will":[94],"be":[95,611],"reproduced.":[96],"Carriage":[97],"variant":[100,296],"allele":[101,175,297],"TNFA-1031*C":[103],"SLC11A1":[105,262,577,608],"D543N*G":[106],"were":[107,127,143,204,275,321,348,408],"associated":[108,162,206,234,276,301],"developing":[112,281],"(IRD)":[116],"Cambodian":[118],"HIV":[119,354,382,430,525,541],"co-infected":[121],"TB.":[123],"However":[124],"these":[125,648,656],"effects":[126,340,646],"not":[128,161,177],"reflected":[129],"Indian":[131],"HIVTB":[132],"patients,":[133,311,431,542],"where":[134],"associations":[136,313,464,629],"an":[140,183,485],"IRD":[141,184],"event":[142,185],"increased":[144,278,498,502],"carriage":[146,324,572],"IL18-607*G":[148],"VDR":[150,171],"FokI":[151],"(F/f)*T.":[152],"In":[153,256,285,309,429,570],"Appendix":[155],"Chapter":[157],"3,":[158],"TB-IRD":[159],"was":[160,422,448],"plasma":[164],"levels":[165,415,503],"Vitamin":[167],"D":[168],"Fok":[172],"(F/f)":[174],"did":[176],"succumbing":[181],"Cambodia,":[190],"India":[191],"nor":[192],"South":[193],"Africa.":[194],"Caucasian":[195,268,310],"carrying":[198,270],"IL28B-rs8099917*TG,":[199],"TNFA-1031*TT,":[200,326],"IL10-1082*AA,":[201],"IL1A+4845*AA":[203],"significantly":[205],"IL10-1082":[210,575],"warrants":[211],"further":[212,558,612],"investigation":[213],"because":[214],"high":[215,380],"production":[216],"IL-10":[218],"by":[219,507],"peripheral":[220],"blood":[221],"mononuclear":[222],"cells":[223,556],"(PBMC)":[224],"has":[228],"been":[229,358,386],"observed":[230,322,630],"previously.":[231],"Genetic":[232,594],"polymorphisms":[233],"(a)":[236],"CMV":[239,252,282,342,370,397,417,426,443,469,479,509,515,561,592],"end-organ":[240,283],"disease,":[241],"(b)":[243],"predisposing":[244],"low":[245,303,315],"nadir":[246,304,316],"CD4":[247,305,317,473],"T":[248,306,318,434,474,555],"cell":[249,307,319,404,435,475],"counts":[250,320],"seropositive":[253,398,427],"HIV-infected":[254],"patients.":[255],"part":[257,286],"(a),":[258],"IL12B":[259],"3\u2019UTR*AA":[260],"D543N*AG":[263],"African":[265,288],"Americans":[266,269,289],"IL10-1082*AG":[271],"LILRB1":[273,331],"I142T*TT":[274],"risk":[279],"(b),":[287],"who":[291,356,384],"carried":[292],"DARC":[293],"T-46C*AA":[294],"CD14":[299],"C(-159)T,":[300],"counts.":[308],"however,":[312],"TNFA-308*A,":[327],"IL2-330*G,":[328],"CCL2-":[329],"2518*GG,":[330],"I142T*C,":[332],"IL10-1082*GG":[333],"IL12B3\u2019UTR*AC.":[335],"Immunological":[336],"driving":[343],"activation":[345,500],"inflammation":[347,505],"a":[351,449,517,537],"cohort":[352,538],"had":[357],"ART":[360,388],"for":[361,389,655],"more":[362,390],"than":[363,391],"12":[364,392,529],"years":[365,530],"good":[367],"viral":[368,544],"suppression.":[369],"antibody":[371],"titres":[372],"(reactive":[373],"lysate,":[375],"gB":[376],"IE1)":[378],"remain":[379],"have":[385],"years,":[393],"compared":[394],"healthy":[396,425],"controls.":[399,428],"Levels":[400],"soluble":[402],"B":[403],"activating":[405],"factor":[406,451],"(sBAFF)":[407],"higher":[409],"correlated":[413,452],"antibodies,":[418],"but":[419],"this":[420,534],"relationship":[421],"unclear":[423],"their":[432],"CD8":[433,457,554],"IFN\u03b3":[436,476],"responses":[437],"against":[438,467],"VLE":[439],"peptide":[440],"IE1":[444,470],"protein":[445,471],"persisted.":[446],"Age":[447],"strong":[450],"CD57+CD45RA+CD27-":[454],"expression":[455],"T-cells.":[458],"This":[459],"senescent":[460],"phenotype":[461,549],"also":[462],"exhibited":[463],"antibodies":[466],"response":[477],"lysate.":[480],"These":[481,511],"results":[482],"point":[483],"towards":[484],"\u201caccelerated\u201d":[486],"ageing":[488,495,565],"effect":[489,519],"normal":[494],"process,":[496],"potentiated":[506],"periodic":[508],"reactivation.":[510],"show":[513],"that":[514],"leaves":[516],"long-lasting":[518],"system":[523],"even":[527],"after":[528],"ART.":[532],"Extending":[533],"study":[535],"including":[539],"CMV-seronegative":[540],"CMV-DNA":[543],"assessments":[545],"evaluation":[547],"function":[551],"CMV-specific":[553],"can":[557],"elucidate":[559],"how":[560],"reactivation":[562],"promotes":[563],"accelerated":[564],"system.":[569],"sum,":[571],"TNFA-1031*T,":[574],"D543N":[578],"stood":[579],"out":[580],"most":[582],"potential":[584],"haplotype":[595],"studies":[596,618,643],"looking":[597],"into":[598,652],"inflammatory":[599],"such":[601],"tumour":[603],"necrosis":[604],"factor,":[605],"IL10":[606],"SNPs":[609,649],"should":[610,619],"investigated":[613],"larger":[615],"cohorts.":[616],"Subsequent":[617],"investigate":[620],"patterns":[621],"linkage":[623],"disequilibrium":[624],"determine":[626],"whether":[627],"here":[631],"reflect":[632],"ethnic":[633],"differences":[634],"haplotypic":[637],"structure":[638],"across":[639],"critical":[640],"genes.":[641],"Functional":[642],"investigating":[644],"evolve":[651],"successful":[653],"therapeutics":[654],"diseases.":[657]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-08-23T00:00:00"}