{"id":"https://openalex.org/W2489932280","doi":"https://doi.org/10.1021/bk-1992-0497.ch019","title":"Genetics and Molecular Biology of the Genes Functioning Late in the Sterol Biosynthetic Pathway of Saccharomyces","display_name":"Genetics and Molecular Biology of the Genes Functioning Late in the Sterol Biosynthetic Pathway of Saccharomyces","publication_year":1992,"publication_date":"1992-07-02","ids":{"openalex":"https://openalex.org/W2489932280","doi":"https://doi.org/10.1021/bk-1992-0497.ch019","mag":"2489932280"},"language":"en","primary_location":{"id":"doi:10.1021/bk-1992-0497.ch019","doi":"https://doi.org/10.1021/bk-1992-0497.ch019","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-1992-0497.ch019","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W634031920","display_name":"Regulation of Isopentenoid Metabolism"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112360479","display_name":"N. Douglas Lees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman D. Lees","raw_affiliation_strings":["Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006815664","display_name":"Beth A. Arthington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth A. Arthington","raw_affiliation_strings":["Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027241044","display_name":"Martin Bard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Bard","raw_affiliation_strings":["Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University\u2014Purdue University at Indianapolis, Indianapolis, IN 46202","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":2.3783,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.85269899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"246","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":0.6039999723434448},{"id":"https://openalex.org/keywords/membrane-structure","display_name":"membrane structure","score":0.628000020980835},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.9309999942779541},{"id":"https://openalex.org/keywords/erg6","display_name":"ERG6","score":0.7129999995231628},{"id":"https://openalex.org/keywords/erg2","display_name":"ERG2","score":0.953000009059906},{"id":"https://openalex.org/keywords/erg3","display_name":"ERG3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-disruption","display_name":"gene disruption","score":0.7170000076293945},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.9639039039611816},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.8095839023590088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5804904699325562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5772882699966431},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5533919334411621},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5515343546867371},{"id":"https://openalex.org/C20950039","wikidata":"https://www.wikidata.org/wiki/Q578111","display_name":"Auxotrophy","level":4,"score":0.5319783091545105},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.47709283232688904},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4727640748023987},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.4130377769470215},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3638446629047394},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.16391006112098694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/bk-1992-0497.ch019","doi":"https://doi.org/10.1021/bk-1992-0497.ch019","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-1992-0497.ch019","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969583685","https://openalex.org/W2123264979","https://openalex.org/W1556292854","https://openalex.org/W2028967650","https://openalex.org/W7064060608","https://openalex.org/W2028649651","https://openalex.org/W4206580508","https://openalex.org/W1971805633","https://openalex.org/W2430850451","https://openalex.org/W2157935239"],"abstract_inverted_index":{"The":[0],"ergosterol":[1,30,48,56],"biosynthetic":[2,49],"pathway":[3,13],"has":[4,31],"been":[5,32,85],"of":[6,21,39,46,55],"interest":[7],"due":[8],"the":[9,12,15,19,22,53,71,78,96,103,113,130],"fact":[10],"that":[11,95],"and":[14,24,43,63,112],"end":[16],"product":[17],"are":[18,119,126],"targets":[20],"azole":[23],"polyene":[25],"antifungals,":[26],"respectively.":[27],"More":[28],"recently":[29],"implicated":[33],"in":[34,57],"some":[35],"key":[36],"regulatory":[37,82],"processes":[38],"fungal":[40],"cells.":[41],"Genetic":[42],"physiological":[44],"analyses":[45],"non-auxotrophic,":[47],"mutants":[50],"have":[51,84,93],"indicated":[52],"roles":[54],"providing":[58],"an":[59],"appropriate":[60],"membrane":[61],"structure":[62],"maintaining":[64],"normal":[65],"permeability":[66],"characteristics.":[67],"Efforts":[68],"to":[69,76],"ascertain":[70],"specific":[72],"structural":[73],"features":[74],"necessary":[75],"provide":[77],"\"sparking\"":[79],"or":[80],"\"hormonal\"":[81],"function":[83],"investigated":[86],"using":[87],"gene":[88],"disruption":[89],"techniques.":[90],"These":[91],"procedures":[92],"shown":[94],"C-24":[97],"sterol":[98],"transmethylase":[99],"(":[100,109,116],"ERG":[101,110,117],"6),":[102],"\u0394":[104],"8":[105],"-\u0394":[106],"7":[107],"isomerase":[108],"2),":[111],"C-5(6)":[114],"desaturase":[115],"3)":[118],"not":[120,127],"required":[121,128],"for":[122,129],"viability":[123],"and,":[124],"thus,":[125],"sparking":[131],"function.":[132]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-08-23T00:00:00"}
