{"id":"https://openalex.org/W2489557154","doi":"https://doi.org/10.1158/0008-5472.can-16-0690","title":"BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses","display_name":"BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses","publication_year":2016,"publication_date":"2016-07-26","ids":{"openalex":"https://openalex.org/W2489557154","doi":"https://doi.org/10.1158/0008-5472.can-16-0690","mag":"2489557154","pmid":"https://pubmed.ncbi.nlm.nih.gov/27630139"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-16-0690","doi":"https://doi.org/10.1158/0008-5472.can-16-0690","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-16-0690","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.le.ac.uk/articles/journal_contribution/BTK_modulates_p53_activity_to_enhance_apoptotic_and_senescent_responses/10153094/1/files/18297686.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011130533","display_name":"Mohammad Althubiti","orcid":"https://orcid.org/0000-0002-9738-3188","observed_orcids":["https://orcid.org/0000-0002-9738-3188"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB","SA"],"is_corresponding":false,"raw_author_name":"Mohammad Althubiti","raw_affiliation_strings":["1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","2Cancer Research UK Leicester Centre, Leicester, United Kingdom","3Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"3Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067075588","display_name":"Miran Rada","orcid":"https://orcid.org/0000-0002-8220-7982","observed_orcids":["https://orcid.org/0000-0002-8220-7982"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I64952554","display_name":"University of Sulaimani","ror":"https://ror.org/00saanr69","country_code":"IQ","type":"education","lineage":["https://openalex.org/I64952554"]}],"countries":["GB","IQ"],"is_corresponding":false,"raw_author_name":"Miran Rada","raw_affiliation_strings":["1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","2Cancer Research UK Leicester Centre, Leicester, United Kingdom","4Department of Biology, School of Science, Faculty of Science and Education Sciences, University of Sulaimani, Sulaimaniyah, Kurdistan Region, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"4Department of Biology, School of Science, Faculty of Science and Education Sciences, University of Sulaimani, Sulaimaniyah, Kurdistan Region, Iraq","institution_ids":["https://openalex.org/I64952554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004727576","display_name":"Jesvin Samuel","orcid":"https://orcid.org/0000-0002-1659-171X","observed_orcids":["https://orcid.org/0000-0002-1659-171X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jesvin Samuel","raw_affiliation_strings":["1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","2Cancer Research UK Leicester Centre, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029923858","display_name":"Josep M. Escorsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Josep M. Escorsa","raw_affiliation_strings":["1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","2Cancer Research UK Leicester Centre, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086295248","display_name":"Hishyar Najeeb","orcid":"https://orcid.org/0000-0002-2869-4214","observed_orcids":["https://orcid.org/0000-0002-2869-4214"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hishyar Najeeb","raw_affiliation_strings":["2Cancer Research UK Leicester Centre, Leicester, United Kingdom","5Department of Cancer Studies, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"5Department of Cancer Studies, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089999495","display_name":"Koon-Guan Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210137615","display_name":"Bioprocessing Technology Institute","ror":"https://ror.org/049fnxe71","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210137615"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Koon-Guan Lee","raw_affiliation_strings":["6Bioprocessing Technology Institute, A*STAR, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Bioprocessing Technology Institute, A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210137615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061550899","display_name":"Kong\u2010Peng Lam","orcid":"https://orcid.org/0000-0002-1316-4333","observed_orcids":["https://orcid.org/0000-0002-1316-4333"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210137615","display_name":"Bioprocessing Technology Institute","ror":"https://ror.org/049fnxe71","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210137615"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kong-Peng Lam","raw_affiliation_strings":["6Bioprocessing Technology Institute, A*STAR, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Bioprocessing Technology Institute, A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210137615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007042251","display_name":"George D.D. Jones","orcid":"https://orcid.org/0000-0002-9543-2206","observed_orcids":["https://orcid.org/0000-0002-9543-2206"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George D.D. Jones","raw_affiliation_strings":["2Cancer Research UK Leicester Centre, Leicester, United Kingdom","5Department of Cancer Studies, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"5Department of Cancer Studies, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037735971","display_name":"Nickolai A. Barlev","orcid":"https://orcid.org/0000-0001-7111-2446","observed_orcids":["https://orcid.org/0000-0001-7111-2446"]},"institutions":[{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nickolai A. Barlev","raw_affiliation_strings":["7Institute of Cytology, RAS, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Institute of Cytology, RAS, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210104940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058272535","display_name":"Salvador Macip","orcid":"https://orcid.org/0000-0003-1963-8840","observed_orcids":["https://orcid.org/0000-0003-1963-8840"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Salvador Macip","raw_affiliation_strings":["1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","2Cancer Research UK Leicester Centre, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"2Cancer Research UK Leicester Centre, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5058272535"],"corresponding_institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2801316944"],"apc_list":null,"apc_paid":null,"fwci":2.6837,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.91472545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"76","issue":"18","first_page":"5405","last_page":"5414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9599999785423279},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8040000200271606},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.609000027179718},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antineoplastic-effects","display_name":"antineoplastic effects","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.9711830615997314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6690230369567871},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5911558866500854},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5827512145042419},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5404743552207947},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5362291932106018},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5211386680603027},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4728184938430786},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46908870339393616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4526413083076477},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4456791579723358},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41784459352493286},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37051475048065186},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30247199535369873},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22343796491622925},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1942598819732666},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17209315299987793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10184681415557861}],"mesh":[{"descriptor_ui":"D000077329","descriptor_name":"Agammaglobulinaemia Tyrosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-16-0690","doi":"https://doi.org/10.1158/0008-5472.can-16-0690","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-16-0690","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:27630139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27630139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:lra.le.ac.uk:2381/38194","doi":null,"is_oa":true,"landing_page_url":"http://cancerres.aacrjournals.org/content/76/18/5405","pdf_url":"https://figshare.le.ac.uk/articles/journal_contribution/BTK_modulates_p53_activity_to_enhance_apoptotic_and_senescent_responses/10153094/1/files/18297686.pdf","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:lra.le.ac.uk:2381/38194","doi":null,"is_oa":true,"landing_page_url":"http://cancerres.aacrjournals.org/content/76/18/5405","pdf_url":"https://figshare.le.ac.uk/articles/journal_contribution/BTK_modulates_p53_activity_to_enhance_apoptotic_and_senescent_responses/10153094/1/files/18297686.pdf","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320276","display_name":"University of Leicester","ror":"https://ror.org/04h699437"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2489557154.pdf","grobid_xml":"https://content.openalex.org/works/W2489557154.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1926957395","https://openalex.org/W1968811042","https://openalex.org/W1970924670","https://openalex.org/W1976295398","https://openalex.org/W1982481909","https://openalex.org/W1993345471","https://openalex.org/W1994451593","https://openalex.org/W1999753979","https://openalex.org/W2003933871","https://openalex.org/W2004314923","https://openalex.org/W2007750331","https://openalex.org/W2007935491","https://openalex.org/W2010706742","https://openalex.org/W2012053348","https://openalex.org/W2013909810","https://openalex.org/W2017055517","https://openalex.org/W2017360265","https://openalex.org/W2020808779","https://openalex.org/W2034562270","https://openalex.org/W2035016256","https://openalex.org/W2039659863","https://openalex.org/W2050901509","https://openalex.org/W2056172893","https://openalex.org/W2058135827","https://openalex.org/W2062284662","https://openalex.org/W2067117191","https://openalex.org/W2071603995","https://openalex.org/W2074452851","https://openalex.org/W2075875145","https://openalex.org/W2081184407","https://openalex.org/W2087999409","https://openalex.org/W2093522627","https://openalex.org/W2095081325","https://openalex.org/W2100550784","https://openalex.org/W2101276900","https://openalex.org/W2102397932","https://openalex.org/W2104908670","https://openalex.org/W2106923566","https://openalex.org/W2113764179","https://openalex.org/W2126525177","https://openalex.org/W2126916805","https://openalex.org/W2130952513","https://openalex.org/W2133916339","https://openalex.org/W2135165486","https://openalex.org/W2145654455","https://openalex.org/W2150851104","https://openalex.org/W2163485102","https://openalex.org/W2163690533","https://openalex.org/W2166422945","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2890311848","https://openalex.org/W2896444571","https://openalex.org/W2770053616","https://openalex.org/W2398372061","https://openalex.org/W1981091855","https://openalex.org/W2081422311","https://openalex.org/W2398711217","https://openalex.org/W2891443059","https://openalex.org/W2063524355","https://openalex.org/W1994610242"],"abstract_inverted_index":{"p53":[0,54,60,70],"is":[1,36,46],"a":[2,37,64,149],"tumor":[3,128],"suppressor":[4,129],"that":[5,31,44,68,105,134],"prevents":[6],"the":[7,75,124,152],"emergence":[8],"of":[9,40,77,126,151,155],"transformed":[10],"cells":[11],"by":[12,25],"inducing":[13],"apoptosis":[14],"or":[15],"senescence,":[16],"among":[17],"other":[18,120],"responses.":[19,130],"Its":[20],"functions":[21],"are":[22],"regulated":[23],"tightly":[24],"posttranslational":[26],"modifications.":[27],"Here":[28],"we":[29],"show":[30],"Bruton's":[32],"tyrosine":[33],"kinase":[34],"(BTK)":[35],"novel":[38],"modulator":[39],"p53.":[41],"We":[42,103],"found":[43],"BTK":[45,56,86,94,115,135,156],"induced":[47],"in":[48,81,109,112,119,141,158],"response":[49,82],"to":[50,59,83],"DNA":[51,98],"damage":[52,99],"and":[53,73,91,101],"activation.":[55],"induction":[57],"leads":[58],"phosphorylation,":[61],"which":[62],"constitutes":[63],"positive":[65],"feedback":[66],"loop":[67],"increases":[69],"protein":[71],"levels":[72],"enhances":[74],"transactivation":[76],"its":[78],"target":[79],"genes":[80],"stress.":[84],"Inhibiting":[85],"reduced":[87],"both":[88],"p53-dependent":[89],"senescence":[90],"apoptosis.":[92,102],"Further,":[93],"expression":[95,136],"also":[96],"upregulated":[97],"signals":[100,111],"conclude":[104],"despite":[106],"being":[107],"involved":[108],"oncogenic":[110],"blood":[113],"malignancies,":[114],"has":[116],"antineoplastic":[117],"properties":[118],"contexts,":[121],"such":[122],"as":[123],"enhancement":[125],"p53's":[127],"Along":[131],"with":[132,138],"evidence":[133],"correlates":[137],"good":[139],"prognosis":[140],"some":[142],"epithelial":[143],"tumors,":[144],"our":[145],"findings":[146],"may":[147],"encourage":[148],"reevaluation":[150],"clinical":[153],"uses":[154],"inhibitors":[157],"cancer":[159],"therapy.":[160],"Cancer":[161],"Res;":[162],"76(18);":[163],"5405-14.":[164],"\u00a92016":[165],"AACR.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}