{"id":"https://openalex.org/W2489489141","doi":"https://doi.org/10.1016/j.celrep.2016.06.103","title":"MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome","display_name":"MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome","publication_year":2016,"publication_date":"2016-08-05","ids":{"openalex":"https://openalex.org/W2489489141","doi":"https://doi.org/10.1016/j.celrep.2016.06.103","mag":"2489489141","pmid":"https://pubmed.ncbi.nlm.nih.gov/27498868"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2016.06.103","doi":"https://doi.org/10.1016/j.celrep.2016.06.103","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.06.103","pdf_url":"http://www.cell.com/article/S2211124716309251/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124716309251/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040994348","display_name":"Xixi Zhang","orcid":"https://orcid.org/0000-0002-0944-2214","observed_orcids":["https://orcid.org/0000-0002-0944-2214"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xixi Zhang","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080880067","display_name":"Cunxian Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cunxian Fan","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110096507","display_name":"Haiwei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiwei Zhang","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143740389","display_name":"Haiwei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiwei Zhang","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Zhao","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101560559","display_name":"Yongbo Liu","orcid":"https://orcid.org/0000-0003-3569-0753","observed_orcids":["https://orcid.org/0000-0003-3569-0753"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongbo Liu","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052533483","display_name":"Chengxian Xu","orcid":"https://orcid.org/0000-0002-6166-8894","observed_orcids":["https://orcid.org/0000-0002-6166-8894"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengxian Xu","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143721964","display_name":"Qun Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Xie","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210115928","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374639","display_name":"Xianjun Yu","orcid":"https://orcid.org/0000-0002-6697-7143","observed_orcids":["https://orcid.org/0000-0002-6697-7143"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Wu","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Department of Biochemistry, Hubei University of Medicine, Shiyan 442000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Department of Biochemistry, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143703668","display_name":"Xianjun Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xianjun Yu","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Department of Biochemistry, Hubei University of Medicine, Shiyan 442000, China","Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Department of Biochemistry, Hubei University of Medicine, Shiyan 442000, China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004972708","display_name":"Haibing Zhang","orcid":"https://orcid.org/0000-0002-8814-7378","observed_orcids":["https://orcid.org/0000-0002-8814-7378"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jianke Zhang","raw_affiliation_strings":["Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004972708","display_name":"Haibing Zhang","orcid":"https://orcid.org/0000-0002-8814-7378","observed_orcids":["https://orcid.org/0000-0002-8814-7378"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haibing Zhang","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004972708","display_name":"Haibing Zhang","orcid":"https://orcid.org/0000-0002-8814-7378","observed_orcids":["https://orcid.org/0000-0002-8814-7378"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haibing Zhang","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: hbzhang@sibs.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5004972708","https://openalex.org/A5110096507"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210165038"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":5.5713,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.96614431,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"16","issue":"12","first_page":"3247","last_page":"3259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mlkl","display_name":"MLKL","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.953000009059906},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/asc-speck-formation","display_name":"ASC speck formation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8259999752044678},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8149999976158142},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6980000138282776},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.9790488481521606},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.8336353898048401},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.6766184568405151},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.5900896787643433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5524901747703552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5337522625923157},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.47741734981536865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4619920551776886},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3732101321220398},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3703881800174713},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.35894668102264404},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2622002363204956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1881798803806305},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14542409777641296}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.celrep.2016.06.103","doi":"https://doi.org/10.1016/j.celrep.2016.06.103","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.06.103","pdf_url":"http://www.cell.com/article/S2211124716309251/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:27498868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27498868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7191534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:mifp-1083","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/mifp/83","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Microbiology and Immunology Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2e0bf4e6e9d24b2db763348578fbc819","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2e0bf4e6e9d24b2db763348578fbc819","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 16, Iss 12, Pp 3247-3259 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2016.06.103","doi":"https://doi.org/10.1016/j.celrep.2016.06.103","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.06.103","pdf_url":"http://www.cell.com/article/S2211124716309251/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2766465774","display_name":null,"funder_award_id":"P30-CA056036","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3227605270","display_name":null,"funder_award_id":"R01 AI119069","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5993815100","display_name":"Targeting Daxx-mediated complex for autoimmune diseases","funder_award_id":"R21AI105794","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320326701","display_name":"Recruitment Program of Global Experts","ror":null},{"id":"https://openalex.org/F4320336656","display_name":"Thousand Young Talents Program of China","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2489489141.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1586591061","https://openalex.org/W1616910822","https://openalex.org/W1636793459","https://openalex.org/W1850224498","https://openalex.org/W1962507920","https://openalex.org/W1971915082","https://openalex.org/W1975593978","https://openalex.org/W1983916999","https://openalex.org/W1987186266","https://openalex.org/W1988848002","https://openalex.org/W1989235336","https://openalex.org/W1991673742","https://openalex.org/W1998983498","https://openalex.org/W2002503549","https://openalex.org/W2007845477","https://openalex.org/W2008961838","https://openalex.org/W2025367550","https://openalex.org/W2032417513","https://openalex.org/W2034006241","https://openalex.org/W2042577315","https://openalex.org/W2048588387","https://openalex.org/W2050518426","https://openalex.org/W2056303166","https://openalex.org/W2057039052","https://openalex.org/W2067043938","https://openalex.org/W2069075668","https://openalex.org/W2069250210","https://openalex.org/W2072540607","https://openalex.org/W2077317536","https://openalex.org/W2078141613","https://openalex.org/W2078252006","https://openalex.org/W2087232320","https://openalex.org/W2087968540","https://openalex.org/W2090234862","https://openalex.org/W2091363184","https://openalex.org/W2094334993","https://openalex.org/W2104205504","https://openalex.org/W2110173959","https://openalex.org/W2118403357","https://openalex.org/W2118621467","https://openalex.org/W2120626244","https://openalex.org/W2120633856","https://openalex.org/W2121842388","https://openalex.org/W2122482353","https://openalex.org/W2124202816","https://openalex.org/W2127205046","https://openalex.org/W2128163368","https://openalex.org/W2128190429","https://openalex.org/W2132161879","https://openalex.org/W2134735862","https://openalex.org/W2142124752","https://openalex.org/W4211217520"],"related_works":["https://openalex.org/W1963534670","https://openalex.org/W1548121369","https://openalex.org/W2775040099","https://openalex.org/W1979178278","https://openalex.org/W3025154789","https://openalex.org/W4388838927","https://openalex.org/W4240111137","https://openalex.org/W2890779590","https://openalex.org/W4399476275","https://openalex.org/W2009958847"],"abstract_inverted_index":{"MLKL,":[0],"a":[1,11],"key":[2],"component":[3],"downstream":[4],"of":[5,14,66],"RIPK3,":[6],"is":[7,55],"suggested":[8],"to":[9,97],"be":[10],"terminal":[12],"executor":[13],"necroptosis.":[15],"Genetic":[16],"studies":[17],"have":[18,106],"revealed":[19],"that":[20,32,63,76,125],"Ripk3":[21],"ablation":[22],"rescues":[23,68],"embryonic":[24],"lethality":[25,51],"in":[26,38,52,72,114,132],"Fadd-":[27],"or":[28],"Caspase-8-deficient":[29],"mice.":[30,99],"Given":[31],"RIPK3":[33],"has":[34],"also":[35],"been":[36],"implicated":[37],"non-necroptotic":[39],"pathways":[40],"including":[41],"apoptosis":[42],"and":[43,75,81,93,103,118,127,136],"inflammatory":[44],"signaling,":[45],"it":[46],"remains":[47],"unclear":[48],"whether":[49],"the":[50,69,138],"Fadd(-/-)":[53],"mice":[54,74,78,84],"indeed":[56],"caused":[57],"by":[58,91],"necropotosis.":[59],"Here,":[60],"we":[61],"show":[62],"genetic":[64],"deletion":[65],"Mlkl":[67],"developmental":[70],"defect":[71],"Fadd-deficient":[73],"Fadd(-/-)Mlkl(-/-)":[77],"are":[79],"viable":[80],"fertile.":[82],"Mlkl(-/-)Fadd(-/-)":[83,100],"display":[85],"significantly":[86],"accelerated":[87],"lymphoproliferative":[88,134],"disease":[89,135],"characterized":[90],"lymphadenopathy":[92],"splenomegaly":[94],"when":[95],"compared":[96],"Ripk3(-/-)Fadd(-/-)":[98],"bone-marrow-derived":[101],"macrophages":[102],"dendritic":[104],"cells":[105],"impaired":[107],"NLRP3":[108,120,139],"inflammasome":[109],"activation":[110],"associated":[111],"with":[112],"defects":[113],"ASC":[115],"speck":[116],"formation":[117],"NF-\u03baB-dependent":[119],"transcription.":[121],"Our":[122],"findings":[123],"reveal":[124],"MLKL":[126],"FADD":[128],"play":[129],"critical":[130],"roles":[131],"preventing":[133],"activating":[137],"inflammasome.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
