{"id":"https://openalex.org/W248724929","doi":null,"title":"Enhancement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L.","display_name":"Enhancement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L.","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W248724929","mag":"248724929"},"language":"en","primary_location":{"id":"mag:248724929","doi":null,"is_oa":false,"landing_page_url":"http://www.pomics.com/liao_5_6_2012_503_507.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S178029676","display_name":"Plant Omics","issn_l":"1836-0661","issn":["1836-0661","1836-3644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4324096556","host_organization_name":"Southern Cross Publishing","host_organization_lineage":["https://openalex.org/P4324096556"],"host_organization_lineage_names":["Southern Cross Publishing"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Plant Omics","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100956271","display_name":"Lien Xiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lien Xiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lixia Zeng","orcid":"https://orcid.org/0009-0008-1650-7929","observed_orcids":["https://orcid.org/0009-0008-1650-7929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lixia Zeng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1650-7929","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334745","display_name":"Yuan Yuan","orcid":"https://orcid.org/0000-0002-1234-6813","observed_orcids":["https://orcid.org/0000-0002-1234-6813","https://orcid.org/0000-0001-7543-5808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1234-6813","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Min Chen","orcid":"https://orcid.org/0000-0002-0676-3143","observed_orcids":["https://orcid.org/0000-0002-0676-3143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0676-3143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321381","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0001-9986-0948","observed_orcids":["https://orcid.org/0000-0001-9986-0948","https://orcid.org/0000-0003-1676-9642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9986-0948","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334302","display_name":"Xiaoqiang Liu","orcid":"https://orcid.org/0000-0003-1640-1354","observed_orcids":["https://orcid.org/0000-0003-1640-1354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqiang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1640-1354","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109490309","display_name":"Lingjiang Zeng","orcid":"https://orcid.org/0009-0001-2488-6657","observed_orcids":["https://orcid.org/0009-0001-2488-6657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingjiang Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000584148","display_name":"Xiaozhong Lan","orcid":"https://orcid.org/0000-0002-8657-5790","observed_orcids":["https://orcid.org/0000-0002-8657-5790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaozhong Lan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8657-5790","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021333738","display_name":"Zhihua Liao","orcid":"https://orcid.org/0000-0002-1283-4649","observed_orcids":["https://orcid.org/0000-0002-1283-4649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihua Liao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1283-4649","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3649,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.7843533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"6","first_page":"503","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin-biosynthesis","display_name":"artemisinin biosynthesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/artemisia-annua","display_name":"Artemisia annua","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.6259999871253967},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.7680000066757202},{"id":"https://openalex.org/keywords/2-c-methyl-d-erythritol-4-phosphate-pathway","display_name":"2-C-methyl-D-erythritol 4-phosphate pathway","score":0.9160000085830688},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cyp71av1","display_name":"CYP71AV1","score":0.925000011920929},{"id":"https://openalex.org/keywords/cpr","display_name":"CPR","score":0.6110000014305115},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.9309999942779541},{"id":"https://openalex.org/keywords/artemisinin-content","display_name":"artemisinin content","score":0.7630000114440918},{"id":"https://openalex.org/keywords/malaria-drugs","display_name":"malaria drugs","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779691961","wikidata":"https://www.wikidata.org/wiki/Q1308044","display_name":"Artemisia annua","level":5,"score":0.9906532764434814},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.988700270652771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6946375370025635},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4915197789669037},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.48324617743492126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34559404850006104},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.1890413761138916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15632286667823792},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.15455874800682068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.046797871589660645},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:248724929","doi":null,"is_oa":false,"landing_page_url":"http://www.pomics.com/liao_5_6_2012_503_507.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S178029676","display_name":"Plant Omics","issn_l":"1836-0661","issn":["1836-0661","1836-3644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4324096556","host_organization_name":"Southern Cross Publishing","host_organization_lineage":["https://openalex.org/P4324096556"],"host_organization_lineage_names":["Southern Cross Publishing"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Plant Omics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1967648518","https://openalex.org/W1969962785","https://openalex.org/W1991394302","https://openalex.org/W1992733039","https://openalex.org/W2006807779","https://openalex.org/W2015823022","https://openalex.org/W2034553168","https://openalex.org/W2038771253","https://openalex.org/W2057823601","https://openalex.org/W2060685213","https://openalex.org/W2072196622","https://openalex.org/W2075579534","https://openalex.org/W2097638068","https://openalex.org/W2137448913","https://openalex.org/W2152038789","https://openalex.org/W2158893859"],"related_works":["https://openalex.org/W2133898951","https://openalex.org/W2581239899","https://openalex.org/W1984156348","https://openalex.org/W2077381490","https://openalex.org/W2463601737","https://openalex.org/W2388558603","https://openalex.org/W2088639933","https://openalex.org/W1971345134","https://openalex.org/W2001707360","https://openalex.org/W4321459122"],"abstract_inverted_index":{"Artemisinin":[0],"is":[1,13],"extracted":[2],"from":[3],"a":[4],"traditional":[5],"Chinese":[6],"medicinal":[7],"herb":[8],"Artemisia":[9],"annua":[10,80,91,111,206,245],"L.,":[11],"which":[12],"regarded":[14],"as":[15],"the":[16,23,34,42,67,108,116,125,133,152,159,175,190,203,211,219,228],"most":[17],"efficient":[18],"drug":[19],"against":[20],"malaria":[21],"in":[22,47,71,132,151],"world.":[24],"In":[25,50],"recent":[26],"years,":[27],"attention":[28],"has":[29],"been":[30],"paid":[31],"to":[32,64,241],"increase":[33,169],"artemisinin":[35,46,68,123,131,171,194,234],"content":[36,44,129,192],"through":[37,104],"transgenic":[38,76,89,109,243],"methods":[39],"because":[40],"of":[41,45,78,84,95,115,122,130,138,162,170,185,193,202,218,227,249],"low":[43],"wild":[48,126,153],"plants.":[49],"this":[51],"article,":[52],"three":[53,200],"functional":[54],"artemisinin-related":[55],"genes":[56],"namely":[57],"dxr,":[58],"cyp71av1":[59,97,164,186],"and":[60,86,98,102,165,187],"cpr,":[61],"were":[62,100],"used":[63],"genetically":[65],"modify":[66],"biosynthesis":[69],"pathway":[70,223,230],"A.":[72,79,90,110,177,205,244],"annua.":[73,178],"Four":[74],"independent":[75,88],"lines":[77,92,161],"plants":[81,112],"with":[82,93,113,136,149,174,183,246],"overexpression":[83,94,114,137,184],"dxr":[85,117,139],"five":[87,160],"both":[96],"cpr":[99,166,188],"obtained":[101],"confirmed":[103],"genomic":[105],"PCR.":[106],"All":[107,158],"gene":[118],"showed":[119],"higher":[120,247],"levels":[121,248],"than":[124,145],"type.":[127],"The":[128],"Line":[134,179],"D24":[135],"(1.21+/-0.01":[140],"mg.g-1":[141,156,196,208],"DW)":[142,197],"was":[143],"more":[144],"two":[146],"times":[147,201],"compared":[148,173],"that":[150,215],"type":[154],"(0.52+/-0.01":[155],"DW).":[157,209],"co-overexpressing":[163],"had":[167,189],"an":[168],"production":[172],"wild-type":[176,204],"No.":[180],"16":[181],"-1":[182],"highest":[191],"(2.44+/-0.13":[195],"at":[198],"nearly":[199],"(0.91+/-0.02":[207],"Thus,":[210],"present":[212],"study":[213],"demonstrated":[214],"genetic":[216],"modification":[217],"upstream":[220],"2-C-methyl-D-erythritol":[221],"4-phosphate":[222],"or":[224],"metabolic":[225],"engineering":[226],"artemisinin-specific":[229],"could,":[231],"respectively,":[232],"enhance":[233],"biosynthesis.":[235],"These":[236],"strategies":[237],"could":[238],"be":[239],"applied":[240],"develop":[242],"artemisinin.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
