{"id":"https://openalex.org/W2486559121","doi":"https://doi.org/10.18143/jisanh_v3i3_1219","title":"Advanced glycation end products induce liver injury in non-alcoholic steatohepatitis (NASH) via hepatocyte NOX4","display_name":"Advanced glycation end products induce liver injury in non-alcoholic steatohepatitis (NASH) via hepatocyte NOX4","publication_year":2016,"publication_date":"2016-06-21","ids":{"openalex":"https://openalex.org/W2486559121","doi":"https://doi.org/10.18143/jisanh_v3i3_1219","mag":"2486559121"},"language":"en","primary_location":{"id":"doi:10.18143/jisanh_v3i3_1219","doi":"https://doi.org/10.18143/jisanh_v3i3_1219","is_oa":true,"landing_page_url":"https://doi.org/10.18143/jisanh_v3i3_1219","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.18143/jisanh_v3i3_1219","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103043445","display_name":"Joy X. Jiang","orcid":"https://orcid.org/0009-0005-4414-0034","observed_orcids":["https://orcid.org/0009-0005-4414-0034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang, Joy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sato, Ai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sato, Ai","raw_affiliation_strings":["UC Davis,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis,","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brandes, Ralph","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandes, Ralph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018173206","display_name":"Natalie Julia Torok","orcid":"https://orcid.org/0000-0001-8074-7048","observed_orcids":["https://orcid.org/0000-0001-8074-7048"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Torok, Natalie","raw_affiliation_strings":["UC Davis,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis,","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08391608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.38920000195503235,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.968999981880188},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.8450000286102295},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hepatocyte-injury","display_name":"hepatocyte injury","score":0.7049999833106995},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.875},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/jnk1-phosphorylation","display_name":"JNK1 phosphorylation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.796999990940094},{"id":"https://openalex.org/keywords/fast-food-diet","display_name":"fast food diet","score":0.8519999980926514},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.8619812726974487},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8494324684143066},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6847996711730957},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.665800929069519},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6406158208847046},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.613312304019928},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.585943341255188},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5473735928535461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5106382966041565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46399590373039246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4538213014602661},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.41915425658226013},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3693350851535797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30569732189178467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3032723665237427},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.22153747081756592},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2033085823059082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20305845141410828},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.16635140776634216},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0586056113243103},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18143/jisanh_v3i3_1219","doi":"https://doi.org/10.18143/jisanh_v3i3_1219","is_oa":true,"landing_page_url":"https://doi.org/10.18143/jisanh_v3i3_1219","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2486559121","doi":null,"is_oa":false,"landing_page_url":"https://search.datacite.org/works/10.18143/jisanh_v3i3_1219","pdf_url":null,"source":{"id":"https://openalex.org/S2764861202","display_name":"Journal of the International Society of Antioxidants in Nutrition & Health","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the International Society of Antioxidants in Nutrition & Health","raw_type":null}],"best_oa_location":{"id":"doi:10.18143/jisanh_v3i3_1219","doi":"https://doi.org/10.18143/jisanh_v3i3_1219","is_oa":true,"landing_page_url":"https://doi.org/10.18143/jisanh_v3i3_1219","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3042163960","https://openalex.org/W1587796776","https://openalex.org/W2058398821","https://openalex.org/W2520817907","https://openalex.org/W2167403850","https://openalex.org/W2020963426","https://openalex.org/W2979736764","https://openalex.org/W1499144972","https://openalex.org/W7098412222","https://openalex.org/W2896004654"],"abstract_inverted_index":{"NASH":[0],"is":[1,26],"leading":[2,54],"cause":[3],"of":[4,30,84,172],"liver":[5,176],"injury,":[6],"and":[7,24,72,82,96,122,134,139,170],"patients":[8,62,118],"with":[9,63,119],"typeII":[10],"DM":[11],"are":[12],"prone":[13],"for":[14],"aggressive":[15],"disease.":[16],"ROS":[17],"play":[18],"a":[19],"key":[20],"role":[21],"in":[22,61,68,117,123,151,164],"progression,":[23],"NOX4":[25,51,105,157],"an":[27],"important":[28],"source":[29],"H2O2;":[31],"but":[32],"the":[33],"mechanisms":[34],"linking":[35],"AGEs":[36,48,81,111],"exposure":[37],"to":[38,55,167,184],"NOX4/RAGE":[39],"signaling":[40],"have":[41],"been":[42],"undefined.":[43],"We":[44],"hypothesized":[45],"that":[46],"circulating":[47],"activate":[49],"hepatocyte":[50],"via":[52],"RAGE":[53,58,114,130],"progressive":[56],"injury.":[57],"was":[59,115,131,148],"studied":[60],"steatosis,":[64],"or":[65],"NASH/":[66],"DM;":[67],"hepatocyte-specific":[69],"NOX4KOs":[70],"(NOX4hepKO)":[71],"fl/fl":[73],"controls":[74],"following":[75],"fast":[76],"food":[77],"diet":[78],"(FFD).":[79],"Liver":[80],"expression":[83],"detoxifying":[85],"enzyme":[86],"AGER1":[87,147,173],"were":[88,94,108,142],"assessed.":[89],"JNK1":[90,140],"phosphorylation,":[91],"ROS,":[92,135],"apoptosis":[93],"evaluated,":[95],"fibrosis":[97,144],"assessed":[98],"(fibrogenic":[99],"transcripts,":[100],"hydroxyl":[101],"proline).":[102],"In":[103,127],"vitro,":[104],"promoter":[106,158],"studies":[107],"done":[109],"after":[110],"exposure.":[112],"Results:":[113],"induced":[116,156],"DM/NASH":[120],"(p<0.05),":[121,133],"mice":[124,129,152],"on":[125,153],"FFD.":[126,154],"NOX4hepKO":[128],"downregulated":[132],"lipid":[136],"peroxidation,":[137],"CHOP":[138],"activation":[141],"attenuated,":[143],"improved":[145],"(p<0.05).":[146],"significantly":[149],"lower":[150],"BSA/AGEs":[155],"activity/H2O2":[159],"release.":[160],"Conclusion:":[161],"AGEs-induced":[162],"NOX4/H2O2":[163],"hepatocytes":[165],"leads":[166],"stress":[168],"signals":[169],"downregulation":[171],"further":[174],"promotes":[175],"fibrosis.":[177],"Targeting":[178],"AGEs/RAGE":[179],"could":[180],"thus":[181],"be":[182],"beneficial":[183],"improve":[185],"outcomes.":[186]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-08-23T00:00:00"}
