{"id":"https://openalex.org/W2484964734","doi":null,"title":"Dosing guidelines for foscarnet and trimetrexate.","display_name":"Dosing guidelines for foscarnet and trimetrexate.","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W2484964734","mag":"2484964734","pmid":"https://pubmed.ncbi.nlm.nih.gov/10144874"},"language":"en","primary_location":{"id":"pmid:10144874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10144874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Formulary (Cleveland, Ohio)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060898142","display_name":"James M Wooten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Wooten","raw_affiliation_strings":["Trinity Lutheran Hospital, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Lutheran Hospital, Kansas City, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692247","display_name":"K Chase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Chase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M C O'Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C O'Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055209422","display_name":"Robyn Henry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Henry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"6","first_page":"349","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foscarnet","display_name":"foscarnet","score":0.9169999957084656},{"id":"https://openalex.org/keywords/trimetrexate","display_name":"trimetrexate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dosing-recommendations","display_name":"dosing recommendations","score":0.9369999766349792},{"id":"https://openalex.org/keywords/drug-monitoring","display_name":"drug monitoring","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.652999997138977},{"id":"https://openalex.org/keywords/hospital-pharmacy-policy","display_name":"hospital pharmacy policy","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.9161434173583984},{"id":"https://openalex.org/C2776724271","wikidata":"https://www.wikidata.org/wiki/Q420387","display_name":"Foscarnet","level":5,"score":0.7480039000511169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6357581615447998},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.5610259771347046},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4968433678150177},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4537239372730255},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.4151095449924469},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34607261419296265},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23382455110549927},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.1567981243133545},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0839417576789856},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06712040305137634},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006745","descriptor_name":"Hospital Bed Capacity, 300 to 499","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008923","descriptor_name":"Missouri","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010606","descriptor_name":"Pharmacy and Therapeutics Committee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016597","descriptor_name":"Trimetrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016597","descriptor_name":"Trimetrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016597","descriptor_name":"Trimetrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10144874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10144874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Formulary (Cleveland, Ohio)","raw_type":"Journal Article"},{"id":"mag:2484964734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10144874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2917591554","https://openalex.org/W2468312866","https://openalex.org/W7062525452","https://openalex.org/W2040272673","https://openalex.org/W4241544257","https://openalex.org/W7095511599","https://openalex.org/W2954360593","https://openalex.org/W2002754803","https://openalex.org/W2161715440","https://openalex.org/W7098011525"],"abstract_inverted_index":{"The":[0],"P":[1],"&":[2],"T":[3],"Committee":[4],"at":[5],"Trinity":[6],"Lutheran":[7],"Hospital,":[8],"a":[9,52],"320-bed,":[10],"community/teaching":[11],"hospital":[12],"in":[13,47],"Kansas":[14],"City,":[15],"MO,":[16],"has":[17],"developed":[18],"dosing":[19,66],"and":[20,27,63,67],"monitoring":[21,68],"guidelines":[22],"for":[23,60],"foscarnet":[24],"sodium":[25],"(Foscavir)":[26],"trimetrexate":[28],"glucuronate":[29],"(Neutrexin)--two":[30],"drugs":[31],"used":[32],"to":[33],"treat":[34],"patients":[35],"with":[36,40],"opportunistic":[37],"infections":[38],"associated":[39],"the":[41,58,64],"human":[42],"immunodeficiency":[43],"virus":[44],"(HIV).":[45],"Presented":[46],"this":[48],"Experience":[49],"Brief":[50],"is":[51],"short":[53],"discussion":[54],"of":[55],"these":[56],"drugs,":[57],"rationale":[59],"guideline":[61],"development,":[62],"actual":[65],"protocols":[69],"devised.":[70]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-08-23T00:00:00"}