{"id":"https://openalex.org/W2484921708","doi":"https://doi.org/10.1007/978-3-319-41603-8_3","title":"Human Pluripotent-Derived Lineages for Repairing Hypopituitarism","display_name":"Human Pluripotent-Derived Lineages for Repairing Hypopituitarism","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2484921708","doi":"https://doi.org/10.1007/978-3-319-41603-8_3","mag":"2484921708"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-41603-8_3","doi":"https://doi.org/10.1007/978-3-319-41603-8_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-41603-8_3","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-319-41603-8_3.pdf","source":{"id":"https://openalex.org/S4210188849","display_name":"Research and perspectives in endocrine interactions","issn_l":"1861-2253","issn":["1861-2253","1863-0685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Endocrine Interactions","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2503816254","display_name":"Stem Cells in Neuroendocrinology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/978-3-319-41603-8_3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065135570","display_name":"Lorenz Studer","orcid":"https://orcid.org/0000-0003-0741-7987","observed_orcids":["https://orcid.org/0000-0003-0741-7987","https://orcid.org/0000-0002-5417-5995"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorenz Studer","raw_affiliation_strings":["Developmental Biology, The Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology, The Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081823120","display_name":"Viviane S. Tabar","orcid":"https://orcid.org/0000-0002-1284-1670","observed_orcids":["https://orcid.org/0000-0002-1284-1670"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Viviane Tabar","raw_affiliation_strings":["Department of Neurosurgery, The Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065135570","https://openalex.org/A5081823120"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.8265,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.698941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"25","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.921999990940094},{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ectopic-transplantation","display_name":"ectopic transplantation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/orthotopic-transplantation","display_name":"orthotopic transplantation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.8466582298278809},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7921496033668518},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5823497772216797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5569429993629456},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.54032301902771},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5313962697982788},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.46718695759773254},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.4250103831291199},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.39076074957847595},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3840576708316803},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3274843096733093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30493050813674927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22533056139945984},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1867876946926117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14142078161239624},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.11971724033355713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.083840012550354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-41603-8_3","doi":"https://doi.org/10.1007/978-3-319-41603-8_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-41603-8_3","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-319-41603-8_3.pdf","source":{"id":"https://openalex.org/S4210188849","display_name":"Research and perspectives in endocrine interactions","issn_l":"1861-2253","issn":["1861-2253","1863-0685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Endocrine Interactions","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.1007/978-3-319-41603-8_3","doi":"https://doi.org/10.1007/978-3-319-41603-8_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-41603-8_3","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-319-41603-8_3.pdf","source":{"id":"https://openalex.org/S4210188849","display_name":"Research and perspectives in endocrine interactions","issn_l":"1861-2253","issn":["1861-2253","1863-0685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Endocrine Interactions","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2484921708.pdf","grobid_xml":"https://content.openalex.org/works/W2484921708.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W97221142","https://openalex.org/W1818304349","https://openalex.org/W1968092893","https://openalex.org/W1970774026","https://openalex.org/W1974394117","https://openalex.org/W1975042974","https://openalex.org/W1976111242","https://openalex.org/W1978655699","https://openalex.org/W1979417832","https://openalex.org/W1980775054","https://openalex.org/W1983222557","https://openalex.org/W1990041423","https://openalex.org/W2001877790","https://openalex.org/W2008370035","https://openalex.org/W2021838607","https://openalex.org/W2025666031","https://openalex.org/W2026139144","https://openalex.org/W2028284029","https://openalex.org/W2028401899","https://openalex.org/W2032472678","https://openalex.org/W2033234433","https://openalex.org/W2034289099","https://openalex.org/W2038583081","https://openalex.org/W2039960217","https://openalex.org/W2045166615","https://openalex.org/W2064697437","https://openalex.org/W2086294280","https://openalex.org/W2086943348","https://openalex.org/W2087786585","https://openalex.org/W2094522722","https://openalex.org/W2095650608","https://openalex.org/W2102678193","https://openalex.org/W2125987139","https://openalex.org/W2129477953","https://openalex.org/W2130128490","https://openalex.org/W2131430964","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2144658476","https://openalex.org/W2148890861","https://openalex.org/W2149884610","https://openalex.org/W2186337672","https://openalex.org/W2197714088","https://openalex.org/W2253932600","https://openalex.org/W2425238125","https://openalex.org/W2592146264","https://openalex.org/W2945945364","https://openalex.org/W4237716976"],"related_works":["https://openalex.org/W2425238125","https://openalex.org/W4256106088","https://openalex.org/W2985028629","https://openalex.org/W2080568815","https://openalex.org/W4415345900","https://openalex.org/W3108050901","https://openalex.org/W3123645186","https://openalex.org/W2887018709","https://openalex.org/W2799354913","https://openalex.org/W4403741360"],"abstract_inverted_index":{"Human":[0],"pluripotent":[1,94],"stem":[2,95],"cells":[3,182],"(hPSCs)":[4],"present":[5,103],"a":[6,125],"potentially":[7],"unlimited":[8],"source":[9,106],"of":[10,59,68,151,179],"specialized":[11],"cell":[12,37,101],"types":[13,38,102],"for":[14,48,62,107],"regenerative":[15],"medicine.":[16],"Over":[17],"the":[18,49,53,57,66,130,149,175,180,184,191,204,211,217],"last":[19],"few":[20],"years":[21],"there":[22,79,123],"has":[23,80],"been":[24,82],"rapid":[25],"progress":[26],"in":[27,39,84,109],"realizing":[28,118],"this":[29,119],"potential":[30,150],"by":[31,190,199,203],"developing":[32],"protocols":[33],"to":[34,127,147,158],"generate":[35],"disease-relevant":[36],"vitro":[40],"on":[41],"demand.":[42],"The":[43,163],"approach":[44],"was":[45],"particularly":[46],"successful":[47],"nervous":[50],"system,":[51],"where":[52],"field":[54],"is":[55,124,208],"at":[56],"verge":[58],"human":[60,93,192],"translation":[61],"several":[63,114],"indications,":[64],"including":[65],"treatment":[67],"eye":[69],"disorders,":[70],"Parkinson\u2019s":[71],"disease":[72],"and":[73,92,132,154,201,210],"spinal":[74],"cord":[75],"injury.":[76],"More":[77],"recently,":[78],"also":[81],"success":[83],"deriving":[85],"anterior":[86],"pituitary":[87,99,193],"lineages":[88,138],"from":[89],"both":[90,152],"mouse":[91],"cells.":[96],"In":[97,121],"vitro-derived":[98],"hormone-producing":[100,137],"an":[104],"attractive":[105],"repair":[108,168],"patients":[110],"with":[111,134],"hypopituitarism.":[112],"However,":[113],"hurdles":[115],"remain":[116],"towards":[117,174],"goal.":[120],"particular,":[122],"need":[126],"further":[128],"improve":[129],"efficiency":[131],"precision":[133],"which":[135],"specific":[136],"can":[139],"be":[140,145,167,214],"derived.":[141],"Furthermore,":[142],"it":[143],"will":[144,166],"important":[146],"assess":[148],"ectopic":[153],"orthotopic":[155],"transplantation":[156],"strategies":[157],"achieve":[159],"meaningful":[160],"hormone":[161,172],"replacement.":[162],"ultimate":[164],"challenge":[165],"that":[169],"moves":[170],"beyond":[171],"replacement":[173],"full":[176],"functional":[177],"integration":[178],"grafted":[181],"into":[183],"complex":[185],"regulatory":[186],"endocrine":[187],"network":[188],"controlled":[189],"gland.":[194],"These":[195],"keywords":[196,212],"were":[197],"added":[198],"machine":[200],"not":[202],"authors.":[205],"This":[206],"process":[207],"experimental":[209],"may":[213],"updated":[215],"as":[216],"learning":[218],"algorithm":[219],"improves.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-08-23T00:00:00"}
