{"id":"https://openalex.org/W24843560","doi":null,"title":"Expression of the multidrug resistance P-glycoprotein and its relationship to hematological characteristics and response to treatment in myelodysplastic syndromes.","display_name":"Expression of the multidrug resistance P-glycoprotein and its relationship to hematological characteristics and response to treatment in myelodysplastic syndromes.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W24843560","mag":"24843560","pmid":"https://pubmed.ncbi.nlm.nih.gov/7516032"},"language":"en","primary_location":{"id":"pmid:7516032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7516032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059980892","display_name":"Pascale Lepelley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Lepelley","raw_affiliation_strings":["Laboratoire d'H\u00e9matologie A, Centre Hospitalier Universitaire de Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9matologie A, Centre Hospitalier Universitaire de Lille, France","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083892956","display_name":"Val\u00e9rie Soenen","orcid":"https://orcid.org/0000-0002-4618-9377","observed_orcids":["https://orcid.org/0000-0002-4618-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Soenen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018416096","display_name":"Claude Preudhomme","orcid":"https://orcid.org/0000-0002-1267-9546","observed_orcids":["https://orcid.org/0000-0002-1267-9546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Preudhomme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J L Lai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Lai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Cosson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Cosson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014838075","display_name":"Pierre Fenaux","orcid":"https://orcid.org/0000-0002-0468-3553","observed_orcids":["https://orcid.org/0000-0002-0468-3553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fenaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5993,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90703844,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"6","first_page":"998","last_page":"1004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8880000114440918},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myeloperoxidase-activity","display_name":"myeloperoxidase activity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.8700000047683716},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.7870000004768372},{"id":"https://openalex.org/keywords/monosomy-7","display_name":"monosomy 7","score":0.996999979019165},{"id":"https://openalex.org/keywords/low-dose-cytarabine","display_name":"low-dose cytarabine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.6355847120285034},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5578229427337646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5294244885444641},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.46382346749305725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4557882845401764},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.4527358412742615},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4426336884498596},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.4411190152168274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4257337152957916},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.41707974672317505},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4137704372406006},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.41128844022750854},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3734314441680908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3051331043243408},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.2884434461593628},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.1714058816432953},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10753431916236877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07268020510673523}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7516032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7516032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Comparative Study"},{"id":"mag:24843560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7516032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1755169583","https://openalex.org/W1968432525","https://openalex.org/W1968865647","https://openalex.org/W1996441843","https://openalex.org/W2001756472","https://openalex.org/W2047253855","https://openalex.org/W2056391616","https://openalex.org/W2078089300","https://openalex.org/W2096539888","https://openalex.org/W2097395605","https://openalex.org/W2126781806","https://openalex.org/W2127521907","https://openalex.org/W2131954113","https://openalex.org/W2133807304","https://openalex.org/W2143943492","https://openalex.org/W2146901298","https://openalex.org/W2149896325","https://openalex.org/W2152265092","https://openalex.org/W2152893570","https://openalex.org/W2159687920","https://openalex.org/W2752336761","https://openalex.org/W3159510662","https://openalex.org/W4213055016","https://openalex.org/W4234329496","https://openalex.org/W4243765000"],"related_works":["https://openalex.org/W2087348472","https://openalex.org/W2468227623","https://openalex.org/W2038188075","https://openalex.org/W2124768772","https://openalex.org/W2068784973","https://openalex.org/W2981241649","https://openalex.org/W2282631985","https://openalex.org/W2910787093","https://openalex.org/W2031186545","https://openalex.org/W95831516"],"abstract_inverted_index":{"Expression":[0],"of":[1,6,37,42,59,75,77,84,130,137,177,187,303,323],"P-glycoprotein":[2],"(PGP),":[3],"the":[4,7,25,73,78,82,128,175,280,301],"product":[5],"multi-drug":[8],"resistance":[9],"mdr1":[10],"gene":[11],"was":[12,65,70,93,124,180,192],"studied":[13],"by":[14],"immunocytochemistry":[15],"on":[16,320],"bone":[17],"marrow":[18],"slides":[19],"using":[20,327],"JSB1":[21],"monoclonal":[22],"antibody":[23],"and":[24,30,57,63,100,115,142,173,201,222,233,249,270],"alkaline":[26],"phosphatase-antialkaline":[27],"phosphatase":[28],"(APAAP)":[29],"avidin-biotin-peroxidase":[31],"(ABC)":[32],"techniques":[33],"in":[34,72,88,95,133,164,205,268,273,283,310,337],"82":[35,79],"cases":[36,212,232,237],"untreated":[38],"myelodysplastic":[39],"syndromes":[40],"(MDS),":[41],"whom":[43],"ten":[44,223,250],"had":[45,153],"evolved":[46],"to":[47,106,127,183,199,263,317],"AML":[48,200],"(MDS-AML).":[49],"The":[50],"relationship":[51],"between":[52,287],"PGP":[53,68,91,122,161,188,304],"expression,":[54,189],"myeloperoxidase":[55,131],"activity":[56,132,332],"immunophenotype":[58],"blast":[60],"cells,":[61],"karyotype":[62],"outcome":[64],"also":[66,334],"analyzed.":[67],"expression":[69,123,145,152,162,305],"found":[71],"blasts":[74,85,138,165],"34":[76],"patients":[80,217,243,275],"(41%),":[81],"majority":[83],"being":[86],"stained":[87],"positive":[89],"cases.":[90],"positivity":[92],"rare":[94],"'low":[96],"risk'":[97,108],"MDS":[98,109,285],"(RA":[99],"RARS:":[101],"2/12":[102],"cases)":[103,114,118],"as":[104],"opposed":[105],"'high":[107],"(RAEB,":[110],"RAEB-T,":[111],"CMML:":[112],"25/60":[113],"MDS-AML":[116],"(7/10":[117],"(p":[119,139,146,156,238,276],"=":[120,140,147,157,239,277],"0.04).":[121],"positively":[125],"correlated":[126,182],"presence":[129,176],"less":[134],"than":[135],"3%":[136],"0.025),":[141],"CD34":[143],"antigen":[144,151],"0.04),":[148],"whereas":[149],"CD33":[150],"borderline":[154],"significance":[155],"0.07),":[158],"demonstrating":[159],"that":[160,300],"predominated":[163],"with":[166,210,246],"an":[167],"immature":[168],"phenotype.":[169],"An":[170],"abnormal":[171],"karyotype,":[172],"especially":[174],"monosomy":[178],"7,":[179],"not":[181,214,259],"a":[184,193],"higher":[185],"incidence":[186],"however.":[190],"There":[191],"trend":[194],"for":[195,202],"more":[196],"frequent":[197],"progression":[198],"shorter":[203],"survival":[204],"PGP-positive":[206,236,274],"cases,":[207],"but":[208],"differences":[209],"PGP-negative":[211,231],"were":[213,244],"significant.":[215],"Twenty":[216,241],"received":[218],"intensive":[219],"anthracycline-Ara-C":[220,288],"chemotherapy":[221],"(50%)":[224,251],"achieved":[225],"complete":[226],"response,":[227],"including":[228],"9/13":[229],"(69%)":[230],"1/7":[234],"(14%)":[235],"0.03).":[240],"other":[242],"treated":[245],"low-dose":[247,264,290],"Ara-C":[248],"responded":[252],"(complete":[253],"or":[254,289],"partial":[255],"response).":[256],"PGP-positivity":[257],"did":[258],"negatively":[260],"affect":[261],"response":[262],"Ara-C:":[265],"4/11":[266],"responses":[267,272],"PGP-negative,":[269],"6/9":[271],"0.18).":[278],"Because":[279],"treatment":[281],"choice":[282],"advanced":[284],"(especially":[286],"Ara-C,":[291],"chemotherapy)":[292],"is":[293],"difficult,":[294],"our":[295],"preliminary":[296],"therapeutic":[297],"results":[298],"suggest":[299],"analysis":[302],"could":[306,333],"have":[307,316],"practical":[308],"importance":[309],"MDS.":[311,338],"These":[312],"findings":[313],"however,":[314],"will":[315],"be":[318,335],"confirmed":[319],"larger":[321],"numbers":[322],"patients.":[324],"Clinical":[325],"trials":[326],"drugs":[328],"potentially":[329],"reverting":[330],"mdr,":[331],"warranted":[336]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}