{"id":"https://openalex.org/W2483850185","doi":null,"title":"\u06a9\u0627\u0647\u0634 \u0628\u06cc\u0627\u0646 \u0698\u0646 CHID1 \u062a\u0648\u0633\u0637 \u0645\u06cc\u06a9\u0631\u0648\u067e\u0627\u0631\u062a\u06cc\u06a9\u0644\u0647\u0627\u06cc \u06a9\u06cc\u062a\u06cc\u0646 \u062f\u0631 \u06a9\u0634\u062a \u0645\u062e\u062a\u0644\u0637 \u0644\u06a9\u0648\u0633\u06cc\u062a\u06cc","display_name":"\u06a9\u0627\u0647\u0634 \u0628\u06cc\u0627\u0646 \u0698\u0646 CHID1 \u062a\u0648\u0633\u0637 \u0645\u06cc\u06a9\u0631\u0648\u067e\u0627\u0631\u062a\u06cc\u06a9\u0644\u0647\u0627\u06cc \u06a9\u06cc\u062a\u06cc\u0646 \u062f\u0631 \u06a9\u0634\u062a \u0645\u062e\u062a\u0644\u0637 \u0644\u06a9\u0648\u0633\u06cc\u062a\u06cc","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2483850185","mag":"2483850185"},"language":"fa","primary_location":{"id":"pmh:oai:doaj.org/article:615d3aa9abac43dcbfddb73010241c45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/615d3aa9abac43dcbfddb73010241c45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i Ar\u0101k, Vol 19, Iss 4, Pp 42-50 (2016)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/615d3aa9abac43dcbfddb73010241c45","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071819125","display_name":"Masumeh Alimohammadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"\u0645\u0639\u0635\u0648\u0645\u0647 \u0639\u0644\u06cc \u0645\u062d\u0645\u062f\u06cc","raw_affiliation_strings":["\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","M.S.c Student, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","institution_ids":["https://openalex.org/I58048189"]},{"raw_affiliation_string":"M.S.c Student, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064534850","display_name":"Farshid Yeganeh","orcid":"https://orcid.org/0000-0001-5128-1840","observed_orcids":["https://orcid.org/0000-0001-5128-1840"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"\u0641\u0631\u0634\u06cc\u062f \u06cc\u06af\u0627\u0646\u0647","raw_affiliation_strings":["\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","Assistant Professor, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","institution_ids":["https://openalex.org/I58048189"]},{"raw_affiliation_string":"Assistant Professor, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055690628","display_name":"Mostafa Haji Molla Hoseini","orcid":"https://orcid.org/0000-0002-5669-3235","observed_orcids":["https://orcid.org/0000-0002-5669-3235"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"\u0645\u0635\u0637\u0641\u06cc \u062d\u0627\u062c\u06cc \u0645\u0644\u0627\u062d\u0633\u06cc\u0646\u06cc","raw_affiliation_strings":["\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","Assistant Professor, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u06af\u0631\u0648\u0647 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc\u060c \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0634\u0647\u06cc\u062f \u0628\u0647\u0634\u062a\u06cc\u060c \u062a\u0647\u0631\u0627\u0646\u060c \u0627\u06cc\u0631\u0627\u0646","institution_ids":["https://openalex.org/I58048189"]},{"raw_affiliation_string":"Assistant Professor, Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"4","first_page":"42","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.4431000053882599,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.4431000053882599,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mixed-leukocyte-culture","display_name":"mixed leukocyte culture","score":0.9200000166893005},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/microparticle-size","display_name":"microparticle size","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.8730000257492065},{"id":"https://openalex.org/keywords/shrimp-shell","display_name":"shrimp shell","score":0.7860000133514404},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/allergy-treatment","display_name":"allergy treatment","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.9078349471092224},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7166556715965271},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6182093024253845},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6013324856758118},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5764096975326538},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5622391700744629},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.5512623190879822},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5141777992248535},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4579774737358093},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4517310857772827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3888532519340515},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.36201977729797363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32902467250823975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26648008823394775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26340770721435547},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11991608142852783},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0767245888710022}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:615d3aa9abac43dcbfddb73010241c45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/615d3aa9abac43dcbfddb73010241c45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i Ar\u0101k, Vol 19, Iss 4, Pp 42-50 (2016)","raw_type":"article"},{"id":"mag:2489350699","doi":null,"is_oa":true,"landing_page_url":"http://jams.arakmu.ac.ir/article-1-4219-fa.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306537787","display_name":"\u0645\u062c\u0644\u0647 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0627\u0631\u0627\u06a9","issn_l":"1735-5338","issn":["1735-5338","2008-644X","2820-7920","3079-7373"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0645\u062c\u0644\u0647 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0627\u0631\u0627\u06a9","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:615d3aa9abac43dcbfddb73010241c45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/615d3aa9abac43dcbfddb73010241c45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i Ar\u0101k, Vol 19, Iss 4, Pp 42-50 (2016)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1672848901","https://openalex.org/W1737796683","https://openalex.org/W1848871989","https://openalex.org/W1893790899","https://openalex.org/W1963741247","https://openalex.org/W1968383728","https://openalex.org/W1975401554","https://openalex.org/W1976370246","https://openalex.org/W2009581246","https://openalex.org/W2011497901","https://openalex.org/W2025131995","https://openalex.org/W2043424050","https://openalex.org/W2050467268","https://openalex.org/W2056109773","https://openalex.org/W2060658521","https://openalex.org/W2063717398","https://openalex.org/W2065616962","https://openalex.org/W2071775990","https://openalex.org/W2097384956","https://openalex.org/W2099556150","https://openalex.org/W2103174126","https://openalex.org/W2110665952","https://openalex.org/W2119315539","https://openalex.org/W2123431656","https://openalex.org/W2131945662","https://openalex.org/W2139619416","https://openalex.org/W2142082641","https://openalex.org/W2154908782","https://openalex.org/W2160451358"],"related_works":["https://openalex.org/W2341151202","https://openalex.org/W3046841108","https://openalex.org/W168709276","https://openalex.org/W2088875349","https://openalex.org/W1672848901","https://openalex.org/W7065624194","https://openalex.org/W2058140180","https://openalex.org/W4413877237","https://openalex.org/W2800998704","https://openalex.org/W3093422988"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"chitin":[2,25,48,126,153,166,180],"and":[3,21,41,45,54,68,78,149,162],"its":[4],"derivates":[5],"microparticles":[6],"(MPs)":[7],"have":[8],"immunomodulatory":[9],"activities.":[10],"In":[11,121],"this":[12],"study,":[13],"we":[14],"examined":[15],"the":[16,195],"effect":[17],"of":[18,24,60,81,88,102,114,134,152],"size,":[19],"purity":[20,148],"acetylation":[22,150],"degree":[23,151],"MPs":[26,49,95,116,127,141,154,167,181],"on":[27,193],"CHID1-":[28],"encoding":[29],"SI-CLP,":[30],"involved":[31],"in":[32,36,58,64,131,158],"inflammation-":[33],"gene":[34,104,122,136,176],"expression":[35,100,123,137],"mixed":[37,62],"leukocyte":[38,61],"culture.":[39],"Materials":[40],"Methods:":[42],"Small":[43],"(<40\uf06d)":[44],"medium(40-70\uf06d)":[46],"sized":[47],"were":[50,56,83,105],"prepared":[51],"by":[52,107],"sonication,":[53],"they":[55],"used":[57,84],"treatment":[59,93,190],"culture":[63],"comparison":[65],"with":[66,94],"chitosan":[67],"also":[69],"shrimp":[70],"shell":[71],"small-sized":[72,125,165,179],"MPs.":[73,89],"Neutral":[74],"red":[75],"uptake":[76],"assay":[77],"microscopic":[79],"examination":[80],"apoptosis":[82],"to":[85,185],"assess":[86],"cytotoxicity":[87],"Finally,":[90],"following":[91],"cell":[92],"(100":[96],"\u03bcg/mL)":[97],"for":[98],"48h,":[99],"levels":[101],"CHID1":[103,135,175],"determined":[106],"Real":[108],"Time":[109],"PCR.":[110],"Results:":[111],"Different":[112],"concentrations":[113],"chitinous":[115],"hadn\u2019t":[117],"any":[118],"cytotoxic":[119],"effects.":[120],"analysis,":[124],"(<40":[128],"\u00b5)":[129],"resulted":[130],"down":[132],"regulation":[133],"(p=0.004),":[138],"while":[139],"other":[140],"didn\u2019t":[142],"change":[143],"it":[144,163],"significantly.":[145],"Conclusion:":[146],"Size,":[147],"influence":[155],"their":[156,189],"interference":[157],"immune":[159,171,196],"cells":[160],"interactions":[161],"seems":[164],"can":[168],"potentially":[169],"modulate":[170],"responses":[172],"through":[173],"decreasing":[174],"expression.":[177],"Using":[178],"may":[182],"be":[183],"effective":[184],"treat":[186],"allergies":[187],"which":[188],"strategies":[191],"rely":[192],"modulating":[194],"responses.":[197]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-08-23T00:00:00"}