{"id":"https://openalex.org/W2483671674","doi":"https://doi.org/10.1002/jrs.4975","title":"Lipid organization and stratum corneum thickness determined in vivo in human skin analyzing lipid\u2013keratin peak (2820\u20133030 cm \u22121 ) using confocal Raman microscopy","display_name":"Lipid organization and stratum corneum thickness determined in vivo in human skin analyzing lipid\u2013keratin peak (2820\u20133030 cm \u22121 ) using confocal Raman microscopy","publication_year":2016,"publication_date":"2016-07-22","ids":{"openalex":"https://openalex.org/W2483671674","doi":"https://doi.org/10.1002/jrs.4975","mag":"2483671674"},"language":"en","primary_location":{"id":"doi:10.1002/jrs.4975","doi":"https://doi.org/10.1002/jrs.4975","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jrs.4975","pdf_url":null,"source":{"id":"https://openalex.org/S4206644","display_name":"Journal of Raman Spectroscopy","issn_l":"0377-0486","issn":["0377-0486","1097-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Raman Spectroscopy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026660191","display_name":"ChunSik Choe","orcid":"https://orcid.org/0000-0003-1633-7962","observed_orcids":["https://orcid.org/0000-0003-1633-7962","https://orcid.org/0000-0001-7465-3299"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I90438679","display_name":"Kim Il-sung University","ror":"https://ror.org/02k98xb21","country_code":"KP","type":"education","lineage":["https://openalex.org/I90438679"]}],"countries":["DE","KP"],"is_corresponding":false,"raw_author_name":"ChunSik Choe","raw_affiliation_strings":["Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany","Kim Il Sung University, Ryongnam-Dong, Taesong District, Pyongyang, Democratic People's Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Kim Il Sung University, Ryongnam-Dong, Taesong District, Pyongyang, Democratic People's Republic of Korea","institution_ids":["https://openalex.org/I90438679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066793527","display_name":"J\u00fcrgen M. Lademann","orcid":"https://orcid.org/0000-0003-1828-7460","observed_orcids":["https://orcid.org/0000-0003-1828-7460"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Lademann","raw_affiliation_strings":["Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044396156","display_name":"Maxim E. Darvin","orcid":"https://orcid.org/0000-0003-1075-1994","observed_orcids":["https://orcid.org/0000-0003-1075-1994"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maxim E. Darvin","raw_affiliation_strings":["Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology  Charit\u00e9platz 1 10117 Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044396156"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":2.1129,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86367206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"11","first_page":"1327","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stratum-corneum-thickness","display_name":"stratum corneum thickness","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intercellular-lipids","display_name":"intercellular lipids","score":0.949999988079071},{"id":"https://openalex.org/keywords/confocal-raman-microscopy","display_name":"confocal Raman microscopy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.7950000166893005},{"id":"https://openalex.org/keywords/solid-fluid-phase-transition","display_name":"solid-fluid phase transition","score":0.8479999899864197},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.8758542537689209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7001525163650513},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6454198360443115},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.5741475820541382},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.49653440713882446},{"id":"https://openalex.org/C149288129","wikidata":"https://www.wikidata.org/wiki/Q185357","display_name":"Phase transition","level":2,"score":0.48180335760116577},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46588367223739624},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.42310184240341187},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3733797073364258},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1864200234413147},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.17915281653404236},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.10162815451622009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07308012247085571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jrs.4975","doi":"https://doi.org/10.1002/jrs.4975","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jrs.4975","pdf_url":null,"source":{"id":"https://openalex.org/S4206644","display_name":"Journal of Raman Spectroscopy","issn_l":"0377-0486","issn":["0377-0486","1097-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Raman Spectroscopy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1572340109","https://openalex.org/W1575659837","https://openalex.org/W1581201881","https://openalex.org/W1844423813","https://openalex.org/W1852276180","https://openalex.org/W1963940444","https://openalex.org/W1987971974","https://openalex.org/W1988565612","https://openalex.org/W1991296357","https://openalex.org/W2004172693","https://openalex.org/W2013041059","https://openalex.org/W2021621463","https://openalex.org/W2030292107","https://openalex.org/W2036452443","https://openalex.org/W2044400339","https://openalex.org/W2047852588","https://openalex.org/W2049155162","https://openalex.org/W2053895905","https://openalex.org/W2060595025","https://openalex.org/W2076571017","https://openalex.org/W2084856901","https://openalex.org/W2085823881","https://openalex.org/W2085981436","https://openalex.org/W2092900714","https://openalex.org/W2092979692","https://openalex.org/W2108863057","https://openalex.org/W2125680340","https://openalex.org/W2127525870","https://openalex.org/W2134740131","https://openalex.org/W2141749825","https://openalex.org/W2150397320","https://openalex.org/W2152946521","https://openalex.org/W2169288745","https://openalex.org/W2194195825","https://openalex.org/W2284633140"],"related_works":["https://openalex.org/W2284633140","https://openalex.org/W3032929488","https://openalex.org/W2901699617","https://openalex.org/W2947596619","https://openalex.org/W4205394942","https://openalex.org/W2611652167","https://openalex.org/W2085981436","https://openalex.org/W4389942461","https://openalex.org/W2932128221","https://openalex.org/W6998757450"],"abstract_inverted_index":{"While":[0],"the":[1,6,15,19,23,30,33,50,56,61,80,83,135,146,149,152,164,175,181,211,222,226,230,232,235,244,248],"intercellular":[2,24],"lipid":[3],"structure":[4],"of":[5,22,32,40,49,75,148,151,180,210,229,234,247],"stratum":[7],"corneum":[8],"(SC)":[9],"plays":[10],"an":[11,125],"important":[12],"role":[13],"in":[14,68,71,225],"skin":[16,34,41,70],"barrier":[17,35],"function,":[18,36],"depth\u2010dependent":[20,47,114],"profile":[21,48],"lipids":[25,182,236],"contributes":[26],"decisively":[27],"to":[28,132,197,243],"deepen":[29],"understanding":[31],"drug":[37],"penetration,":[38],"development":[39],"diseases":[42],"and":[43,60,101,110,116,190,208,224,240],"their":[44,113],"medication.":[45],"The":[46,92,160,178,205],"lipids'":[51],"chemico\u2010physical":[52],"properties,":[53],"such":[54],"as":[55],"solid\u2013fluid":[57],"phase":[58],"transition":[59],"order\u2013disorder":[62],"transition,":[63],"can":[64],"exclusively":[65],"be":[66,130,171],"measured":[67],"human":[69],"vivo":[72],"by":[73],"means":[74],"confocal":[76],"Raman":[77,94],"microscopy.":[78],"In":[79],"present":[81],"paper,":[82],"lipid\u2013keratin":[84],"peak":[85,153,168,213],"(2820\u20133030":[86],"cm":[87,99,103,141,157,166,217],"\u22121":[88,100,104,142,158,167,218],")":[89],"was":[90],"investigated.":[91],"lipid\u2010related":[93],"peaks":[95],"centered":[96,154,214],"at":[97,215],"2850":[98,216],"2880":[102,140,156,165],"were":[105],"deconvoluted":[106],"using":[107],"Gaussian":[108,127,212],"functions":[109],"investigated":[111],"for":[112,173],"shape":[115],"positional":[117],"changes.":[118],"Different":[119],"fitting":[120],"procedures":[121],"show":[122,162,219],"that":[123,163,220],"even":[124],"additional":[126],"function":[128],"cannot":[129],"used":[131,172],"fully":[133],"characterize":[134],"lipid's":[136],"polymethylene":[137],"chains":[138],"around":[139],",":[143],"which":[144],"justifies":[145],"introduction":[147],"sharpness":[150,169],"near":[155,221],".":[159],"results":[161],"might":[170],"determining":[174],"SC":[176],"thickness.":[177],"concentration":[179],"with":[183],"long\u2010chain":[184],"carbon":[185],"backbone":[186],"(free":[187],"fatty":[188],"acids":[189],"ceramides)":[191],"semi\u2010quantitatively":[192],"decreases":[193],"from":[194],"10":[195],"\u00b5m":[196,199],"20":[198],"(SC":[200],"thickness":[201],"is":[202,237],"19.8":[203],"\u00b5m).":[204],"maximum":[206],"position":[207],"broadness":[209],"surface":[223],"deeper":[227],"layers":[228,246],"SC,":[231],"state":[233],"more":[238],"fluid":[239],"disordered":[241],"compared":[242],"medium":[245],"SC.":[249],"Copyright":[250],"\u00a9":[251],"2016":[252],"John":[253],"Wiley":[254],"&":[255],"Sons,":[256],"Ltd.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-08-23T00:00:00"}
