{"id":"https://openalex.org/W2483609591","doi":"https://doi.org/10.1016/j.phrs.2016.07.029","title":"The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators","display_name":"The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators","publication_year":2016,"publication_date":"2016-07-26","ids":{"openalex":"https://openalex.org/W2483609591","doi":"https://doi.org/10.1016/j.phrs.2016.07.029","mag":"2483609591","pmid":"https://pubmed.ncbi.nlm.nih.gov/27461137"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2016.07.029","doi":"https://doi.org/10.1016/j.phrs.2016.07.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2016.07.029","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080077855","display_name":"Barbara Capuani","orcid":"https://orcid.org/0000-0002-2407-2709","observed_orcids":["https://orcid.org/0000-0002-2407-2709"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Capuani","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070276772","display_name":"Francesca Pacifici","orcid":"https://orcid.org/0000-0001-9014-7492","observed_orcids":["https://orcid.org/0000-0001-9014-7492"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Pacifici","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061245586","display_name":"Donatella Pastore","orcid":"https://orcid.org/0000-0002-2284-6256","observed_orcids":["https://orcid.org/0000-0002-2284-6256"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Pastore","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028502166","display_name":"Raffaele Palmirotta","orcid":"https://orcid.org/0000-0002-9401-7377","observed_orcids":["https://orcid.org/0000-0002-9401-7377"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Palmirotta","raw_affiliation_strings":["Department of Biomedical Sciences and Human Oncology, University of Bari \u2fffAldo Moro\u2fff, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Human Oncology, University of Bari \u2fffAldo Moro\u2fff, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073001802","display_name":"Giulia Donadel","orcid":"https://orcid.org/0000-0002-2454-5940","observed_orcids":["https://orcid.org/0000-0002-2454-5940"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Donadel","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023919260","display_name":"Roberto Arriga","orcid":"https://orcid.org/0000-0002-1407-7995","observed_orcids":["https://orcid.org/0000-0002-1407-7995"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Arriga","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002191409","display_name":"Alfonso Bellia","orcid":"https://orcid.org/0000-0003-1975-4622","observed_orcids":["https://orcid.org/0000-0003-1975-4622"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Bellia","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013605540","display_name":"Nicola Di Daniele","orcid":"https://orcid.org/0000-0001-7671-0015","observed_orcids":["https://orcid.org/0000-0001-7671-0015"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Di Daniele","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053217610","display_name":"Paola Rogliani","orcid":"https://orcid.org/0000-0001-7801-5040","observed_orcids":["https://orcid.org/0000-0001-7801-5040"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Rogliani","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059557407","display_name":"Pasquale Abete","orcid":"https://orcid.org/0000-0002-4585-5390","observed_orcids":["https://orcid.org/0000-0002-4585-5390"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Abete","raw_affiliation_strings":["Department of Translational Medical Sciences, University of Naples \u2fffFederico II\u2fff, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medical Sciences, University of Naples \u2fffFederico II\u2fff, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040809526","display_name":"Paolo Sbraccia","orcid":"https://orcid.org/0000-0001-9634-1501","observed_orcids":["https://orcid.org/0000-0001-9634-1501"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Sbraccia","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087184743","display_name":"Fiorella Guadagni","orcid":"https://orcid.org/0000-0003-3652-0457","observed_orcids":["https://orcid.org/0000-0003-3652-0457"]},"institutions":[{"id":"https://openalex.org/I292310028","display_name":"San Raffaele University of Rome","ror":"https://ror.org/02rwycx38","country_code":"IT","type":"education","lineage":["https://openalex.org/I292310028"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fiorella Guadagni","raw_affiliation_strings":["IRCCS San Raffaele Pisana, Rome, Italy; San Raffaele Roma Open University, Via di Val Cannuta 247, 00166 Rome, Italy","IRCCS San Raffaele Pisana, Rome, Italy","San Raffaele Roma Open University, Via di Val Cannuta 247, 00166 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS San Raffaele Pisana, Rome, Italy; San Raffaele Roma Open University, Via di Val Cannuta 247, 00166 Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]},{"raw_affiliation_string":"IRCCS San Raffaele Pisana, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]},{"raw_affiliation_string":"San Raffaele Roma Open University, Via di Val Cannuta 247, 00166 Rome, Italy","institution_ids":["https://openalex.org/I292310028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040626995","display_name":"Davide Lauro","orcid":"https://orcid.org/0000-0002-8597-4415","observed_orcids":["https://orcid.org/0000-0002-8597-4415"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Lauro","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014339603","display_name":"David Della\u2010Morte","orcid":"https://orcid.org/0000-0002-4054-5318","observed_orcids":["https://orcid.org/0000-0002-4054-5318"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"David Della-Morte","raw_affiliation_strings":["Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: david.dellamorte@uniroma2.it","Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","IRCCS San Raffaele Pisana, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: david.dellamorte@uniroma2.it","institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4387155925"]},{"raw_affiliation_string":"Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"IRCCS San Raffaele Pisana, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014339603"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4387155925"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.1732,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.11239227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"111","issue":null,"first_page":"659","last_page":"667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.2939000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pkc-epsilon","display_name":"protein kinase C epsilon","score":0.5070000290870667},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.8700000047683716},{"id":"https://openalex.org/keywords/rack1","display_name":"RACK1","score":0.7279999852180481},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8870000243186951},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9850000143051147},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.984000027179718},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.693646252155304},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5485764145851135},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5247021913528442},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5001301765441895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48446154594421387},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3922686278820038},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3682916760444641},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3621900677680969},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33597397804260254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3265272378921509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2742112874984741},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051744","descriptor_name":"Protein Kinase C-epsilon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.phrs.2016.07.029","doi":"https://doi.org/10.1016/j.phrs.2016.07.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2016.07.029","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:27461137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27461137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/162171","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/162171","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/419899","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/419899","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G735564054","display_name":null,"funder_award_id":"ASI N 2013-084-R0","funder_id":"https://openalex.org/F4320329188","funder_display_name":"Fondazione Roma"},{"id":"https://openalex.org/G80250116","display_name":null,"funder_award_id":"PON03PE_00146_1/10 BIBIOFAR","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322256","display_name":"Agenzia Spaziale Italiana","ror":"https://ror.org/034zgem50"},{"id":"https://openalex.org/F4320329188","display_name":"Fondazione Roma","ror":"https://ror.org/00gtjrz72"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W73419080","https://openalex.org/W146060167","https://openalex.org/W160124365","https://openalex.org/W1495346616","https://openalex.org/W1505322864","https://openalex.org/W1522964491","https://openalex.org/W1548282268","https://openalex.org/W1572814792","https://openalex.org/W1605897432","https://openalex.org/W1627959939","https://openalex.org/W1923848893","https://openalex.org/W1964037972","https://openalex.org/W1964119626","https://openalex.org/W1964476797","https://openalex.org/W1964814025","https://openalex.org/W1966452389","https://openalex.org/W1967526945","https://openalex.org/W1969315619","https://openalex.org/W1972749842","https://openalex.org/W1980376595","https://openalex.org/W1981460885","https://openalex.org/W1983453097","https://openalex.org/W1985415000","https://openalex.org/W1986072187","https://openalex.org/W1988479401","https://openalex.org/W1988649727","https://openalex.org/W1998349282","https://openalex.org/W1999735510","https://openalex.org/W2002665361","https://openalex.org/W2004585452","https://openalex.org/W2006995520","https://openalex.org/W2011397271","https://openalex.org/W2011944039","https://openalex.org/W2012295774","https://openalex.org/W2012978268","https://openalex.org/W2014430771","https://openalex.org/W2019401056","https://openalex.org/W2020182719","https://openalex.org/W2020250769","https://openalex.org/W2022604528","https://openalex.org/W2023494473","https://openalex.org/W2025242285","https://openalex.org/W2032334145","https://openalex.org/W2033242679","https://openalex.org/W2036342252","https://openalex.org/W2040109162","https://openalex.org/W2041169080","https://openalex.org/W2041741792","https://openalex.org/W2042344320","https://openalex.org/W2044823377","https://openalex.org/W2055660210","https://openalex.org/W2056944988","https://openalex.org/W2057628589","https://openalex.org/W2058261129","https://openalex.org/W2062311628","https://openalex.org/W2063646140","https://openalex.org/W2065188205","https://openalex.org/W2065261177","https://openalex.org/W2065902339","https://openalex.org/W2069537903","https://openalex.org/W2070922805","https://openalex.org/W2072347527","https://openalex.org/W2080218239","https://openalex.org/W2082340869","https://openalex.org/W2087410169","https://openalex.org/W2089330962","https://openalex.org/W2089475281","https://openalex.org/W2089514906","https://openalex.org/W2094051977","https://openalex.org/W2096279860","https://openalex.org/W2097035621","https://openalex.org/W2098386685","https://openalex.org/W2100981123","https://openalex.org/W2101773993","https://openalex.org/W2104172033","https://openalex.org/W2108090119","https://openalex.org/W2112291880","https://openalex.org/W2114853537","https://openalex.org/W2120007291","https://openalex.org/W2123048393","https://openalex.org/W2123733969","https://openalex.org/W2126317966","https://openalex.org/W2126736750","https://openalex.org/W2128766770","https://openalex.org/W2129467599","https://openalex.org/W2131570311","https://openalex.org/W2134555179","https://openalex.org/W2136149489","https://openalex.org/W2146217294","https://openalex.org/W2147310804","https://openalex.org/W2152056635","https://openalex.org/W2161407210","https://openalex.org/W2164412143","https://openalex.org/W2165028825","https://openalex.org/W2165066714","https://openalex.org/W2167366932","https://openalex.org/W2186114039","https://openalex.org/W2277623204","https://openalex.org/W2305450898","https://openalex.org/W2316477829","https://openalex.org/W2319963755","https://openalex.org/W2326243064","https://openalex.org/W2327883130","https://openalex.org/W2328561433","https://openalex.org/W2334544892","https://openalex.org/W2342398386","https://openalex.org/W2412338007","https://openalex.org/W2412680253","https://openalex.org/W2426344660","https://openalex.org/W6827237672"],"related_works":["https://openalex.org/W2135943575","https://openalex.org/W2012978268","https://openalex.org/W2096279860","https://openalex.org/W2149360735","https://openalex.org/W2102200534","https://openalex.org/W2040764539","https://openalex.org/W2119333256","https://openalex.org/W2072939316","https://openalex.org/W7135550303","https://openalex.org/W1999735510"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}