{"id":"https://openalex.org/W2483517954","doi":null,"title":"Therapeutic Strategies For Initial Treatment Of AL Amyloidosis: Implications Of Therapy and Response On Outcome","display_name":"Therapeutic Strategies For Initial Treatment Of AL Amyloidosis: Implications Of Therapy and Response On Outcome","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2483517954","mag":"2483517954"},"language":"en","primary_location":{"id":"mag:2483517954","doi":null,"is_oa":false,"landing_page_url":"http://www.bloodjournal.org/content/122/21/3343.figures-only?sso-checked=true","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000308170","display_name":"Angela A. Dispenzieri","orcid":"https://orcid.org/0000-0001-8780-9512","observed_orcids":["https://orcid.org/0000-0001-8780-9512"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Dispenzieri","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0001-8780-9512","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012884078","display_name":"Morie Abraham Gertz","orcid":"https://orcid.org/0000-0002-3853-5196","observed_orcids":["https://orcid.org/0000-0002-3853-5196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morie A. Gertz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3853-5196","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Macp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Macp","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076611748","display_name":"Martha Q. Lacy","orcid":"https://orcid.org/0000-0003-1193-1559","observed_orcids":["https://orcid.org/0000-0003-1193-1559"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Q. Lacy","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0003-1193-1559","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012403700","display_name":"Francis K. Buadi","orcid":"https://orcid.org/0000-0003-3214-0203","observed_orcids":["https://orcid.org/0000-0003-3214-0203"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis K. Buadi","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0003-3214-0203","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107600285","display_name":"Suzanne R. Hayman","orcid":"https://orcid.org/0000-0001-9422-2621","observed_orcids":["https://orcid.org/0000-0001-9422-2621"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne R. Hayman","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016853434","display_name":"Nelson Leung","orcid":"https://orcid.org/0000-0002-5651-1411","observed_orcids":["https://orcid.org/0000-0002-5651-1411"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson Leung","raw_affiliation_strings":["Division of Nephrology and Hypertension, Mayo Clinic, Rochester MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-5651-1411","affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007507517","display_name":"Arleigh B. Robertson McCurdy","orcid":"https://orcid.org/0000-0002-8809-4368","observed_orcids":["https://orcid.org/0000-0002-8809-4368"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arleigh McCurdy","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-8809-4368","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042275995","display_name":"Yi L. Hwa","orcid":"https://orcid.org/0000-0002-8163-2979","observed_orcids":["https://orcid.org/0000-0002-8163-2979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi L. Hwa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8163-2979","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000913712","display_name":"CNP","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CNP","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004","observed_orcids":["https://orcid.org/0000-0001-7477-3004"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dingli","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0001-7477-3004","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033220547","display_name":"Prashant Kapoor","orcid":"https://orcid.org/0000-0002-4342-364X","observed_orcids":["https://orcid.org/0000-0002-4342-364X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashant Kapoor","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052346975","display_name":"Steven R. Zeldenrust","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Zeldenrust","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110499848","display_name":"John Anthony Lust","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Lust","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051470930","display_name":"Stephen J. Russell","orcid":"https://orcid.org/0009-0007-8925-5163","observed_orcids":["https://orcid.org/0009-0007-8925-5163","https://orcid.org/0000-0002-0799-6432"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Russell","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-0799-6432","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066940168","display_name":"S. Vincent Rajkumar","orcid":"https://orcid.org/0000-0002-5862-1833","observed_orcids":["https://orcid.org/0000-0002-5862-1833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Vincent Rajkumar","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-5862-1833","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026574827","display_name":"Shaji Kunnathu Kumar","orcid":"https://orcid.org/0000-0001-5392-9284","observed_orcids":["https://orcid.org/0000-0001-5392-9284"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaji Kumar","raw_affiliation_strings":["Division of Hematology, Mayo Clinic Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0001-5392-9284","affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.20399486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"122","issue":"21","first_page":"3343","last_page":"3343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/al-amyloidosis","display_name":"AL amyloidosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/initial-treatment","display_name":"initial treatment","score":0.5450000166893005},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.949999988079071},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/mayo-staging","display_name":"Mayo staging","score":0.6439999938011169},{"id":"https://openalex.org/keywords/treatment-patterns","display_name":"treatment patterns","score":0.5580000281333923},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4410000145435333},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.3050000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.4740000069141388},{"id":"https://openalex.org/keywords/post-relapse-survival","display_name":"survival after relapse","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8541918992996216},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.5767708420753479},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.5274237394332886},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.510178804397583},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5065816640853882},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5046590566635132},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.5036248564720154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.495458722114563},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.47136083245277405},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45243245363235474},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4149303436279297},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3448227643966675},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2483517954","doi":null,"is_oa":false,"landing_page_url":"http://www.bloodjournal.org/content/122/21/3343.figures-only?sso-checked=true","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2552816170","https://openalex.org/W2576484918","https://openalex.org/W2015950109","https://openalex.org/W2562685394","https://openalex.org/W2574819752","https://openalex.org/W2496517355","https://openalex.org/W2979796411","https://openalex.org/W2518740313","https://openalex.org/W2530875354","https://openalex.org/W2344594786","https://openalex.org/W2561258901","https://openalex.org/W3002453310","https://openalex.org/W2538264893","https://openalex.org/W2913173376","https://openalex.org/W3095729678","https://openalex.org/W3095683256","https://openalex.org/W2566193491","https://openalex.org/W1189657119","https://openalex.org/W2980103903","https://openalex.org/W2988508340"],"abstract_inverted_index":{"![Graphic][1]":[0],"\n\nBackground":[1],"Treatment":[2,241],"of":[3,32,58,67,86,103,173,277,360,471,502,523,533,536,547,562,566,593,609],"AL":[4,71],"amyloidosis":[5],"(AL)":[6],"has":[7,17],"typically":[8],"followed":[9],"the":[10,25,50,56,64,90,122,155,171,189,200,204,232,272,311,315,320,331,343,357,459,489,513,516,520,530,534,545,563,572,598,606],"treatment":[11,147,251],"patterns":[12],"used":[13],"in":[14,19,144,203,231,284,291,297,301,307,330,342,352,403,515,611],"myeloma,":[15],"but":[16],"changed":[18],"a":[20,101,444,469,498,506,556,560],"disease":[21],"specific":[22],"manner":[23],"during":[24,121],"past":[26],"few":[27],"years":[28,180],"with":[29,60,70,268,319,338,356,406,430,468,481,519],"increasing":[30],"use":[31,522],"Melphalan-Dexamethasone":[33],"(MD)":[34],"combination":[35],"as":[36,38,542,544,605],"well":[37,543,604],"bortezomib":[39],"(Btz)":[40],"and":[41,79,82,94,107,130,146,165,195,225,239,304,334,367,384,400,411,423,435,540],"IMiD":[42,295,584],"based":[43,281,296,300,306,327,525,585,589],"regimens.":[44],"It":[45],"is":[46],"not":[47,247,452,478,575],"clear":[48],"how":[49],"more":[51,499],"recent":[52,500],"approaches":[53],"have":[54,451,555],"impacted":[55],"outcome":[57,541],"patients":[59,69,115,201,230,286,324,336,404,428,449,461,467,503,552,569,580,610],"AL.\n\nMethods":[61],"We":[62,112],"reviewed":[63],"medical":[65,105],"records":[66,106],"555":[68],"seen":[72,394,504],"at":[73,170,505],"Mayo":[74,234],"Clinic":[75],"between":[76,579],"Jan":[77],"2004":[78,126],"Dec":[80,138],"2010":[81],"within":[83],"30":[84],"days":[85],"diagnosis.":[87],"Details":[88],"regarding":[89],"laboratory":[91],"findings,":[92],"treatments":[93,316],"response":[95,348,359,369,378,490,538],"to":[96,127,137,140,447,456,487,511],"therapy":[97,278,328,586],"were":[98,168,245,317,329,341,380,441],"extracted":[99],"by":[100],"review":[102],"their":[104],"from":[108,374,416,570],"an":[109,464,548],"existing":[110],"database.":[111],"further":[113],"grouped":[114],"into":[116],"two":[117,205,312],"groups:":[118],"those":[119,131,485],"diagnosed":[120,132],"initial":[123],"half":[124],"(Jan":[125],"June":[128],"2007)":[129],"after":[133],"that":[134,476],"(July":[135],"2007":[136],"2010)":[139],"study":[141],"time":[142,172,206,313,455],"trends":[143],"survival":[145,186],"patterns.\n\nResults":[148],"The":[149,175,183,209,217,258,274,371,413,439,494,527,591],"median":[150,176,184,218,259,372,414,474],"estimated":[151],"follow":[152,243,601],"up":[153,244,602],"for":[154,188,199,214,229,254,261,271,376,427,463,484],"entire":[156,190],"group":[157,263],"was":[158,178,192,196,212,220,252,264,279,393,418,477],"67":[159],"months":[160,194,425],"(95%":[161],"CI;":[162],"59,":[163],"72)":[164],"182":[166],"(33%)":[167],"alive":[169],"analysis.":[174],"age":[177],"64":[179],"(range;":[181],"32-95).":[182],"overall":[185],"(OS)":[187],"cohort":[191,501],"21":[193],"nearly":[197],"identical":[198],"included":[202],"groups;":[207],"P=0.5.":[208],"2-year":[210],"mortality":[211],"52%":[213],"both":[215],"groups.":[216],"OS":[219,260,373,415,475,573],"NR,":[221,222],"24":[223],"mos.":[224,227,266,270],"6":[226,424],"respectively":[228,387,402,426],"revised":[233],"stages":[235],"1,":[236],"2,":[237],"3,":[238],"4.":[240],"details/":[242],"either":[246],"available":[248],"or":[249,391,587],"no":[250,368],"employed":[253],"131":[255],"(24%)":[256,293],"patients.":[257],"this":[262],"3":[265],"compared":[267,480],"36":[269,302],"rest.":[273],"first":[275],"line":[276],"alkylator":[280,582],"(mostly":[282],"Mel-Dex)":[283],"212":[285],"(51%),":[287],"autologous":[288],"transplant":[289],"(SCT)":[290],"99":[292],"patients,":[294],"37(9%),":[298],"Btz":[299,326,524,588],"(9%)":[303],"steroid":[305],"29":[308],"(7%).":[309],"Comparing":[310],"periods,":[314],"similar":[318,442],"following":[321],"exceptions:":[322],"32/36":[323],"receiving":[325,581],"later":[332],"group;":[333],"26/29":[335],"treated":[337,405,429],"steroids":[339],"alone":[340],"former":[344],"group.":[345],"A":[346,389],"hematologic":[347,537],"could":[349],"be":[350],"determined":[351],"275":[353],"(65%)":[354],"patients;":[355],"best":[358],"CR":[361,392],"(17%),":[362],"VGPR":[363,390],"(18%),":[364],"PR":[365],"(14%)":[366],"(17%).":[370],"diagnosis":[375,417],"these":[377],"categories":[379],"99,":[381,419],"53,":[382],"27":[383,482],"12":[385],"mos":[386,483],"(p<0.01).":[388],"among":[395],"55%,":[396],"39%,":[397],"29%,":[398],"26%":[399],"10%":[401],"SCT,":[407,431,571],"Btz,":[408,432],"Alkylators,":[409,433],"IMiDs":[410,434],"steroids.":[412],"34,":[420],"25,":[421,422],"steroids,":[436],"P<0.01":[437],"([Figure][2]).":[438],"results":[440,528],"using":[443],"4-month":[445],"landmark":[446],"exclude":[448],"who":[450],"had":[453,473],"adequate":[454],"respond.":[457],"Among":[458],"146":[460],"evaluable":[462],"NT-PRoBNP":[465],"response,":[466],"decrease":[470],"30%":[472],"reached":[479],"failing":[486],"achieve":[488],"(4":[491],"month":[492],"landmark).\n\nConclusion":[493],"current":[495],"data":[496],"form":[497],"single":[507],"referral":[508],"institution":[509],"serves":[510],"highlight":[512],"shift":[514],"therapeutic":[517],"approaches,":[518],"increased":[521],"combinations.":[526],"confirm":[529],"prior":[531],"observations":[532],"impact":[535],"depth":[539],"effect":[546],"NT-ProBNP":[549],"response.":[550],"While":[551],"undergoing":[553],"SCT":[554],"better":[557],"outcome,":[558],"likely":[559],"result":[561],"selection":[564],"bias":[565],"excluding":[567],"high-risk":[568],"do":[574],"appear":[576],"significantly":[577],"different":[578],"therapy,":[583],"therapy.":[590],"lack":[592],"difference":[594],"may":[595],"also":[596],"reflect":[597],"relatively":[599],"shorter":[600],"s":[603],"small":[607],"numbers":[608],"each":[612],"group.\n\n![Figure][3]":[613],"\n\nDisclosures:":[614],"Kumar:":[615],"Celgene:":[616],"Consultancy,":[617,621,625],"Research":[618,622,626],"Funding;":[619,623],"Millennium:":[620],"Onyx:":[624],"Funding.\n\n":[627],"[1]:":[628],"/embed/inline-graphic-2.gif\n":[629],"[2]:":[630],"#F1\n":[631],"[3]:":[632],"pending:yes":[633]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}