{"id":"https://openalex.org/W2483100198","doi":"https://doi.org/10.1158/1538-7445.am2016-1144","title":"Abstract 1144: Detection of a novel ALK fusion variant in lung adenocarcinoma using a comprehensive genomic analysis","display_name":"Abstract 1144: Detection of a novel ALK fusion variant in lung adenocarcinoma using a comprehensive genomic analysis","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2483100198","doi":"https://doi.org/10.1158/1538-7445.am2016-1144","mag":"2483100198"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-1144","doi":"https://doi.org/10.1158/1538-7445.am2016-1144","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1144","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003352142","display_name":"Kazuhiko Shien","orcid":"https://orcid.org/0000-0002-4959-4220","observed_orcids":["https://orcid.org/0000-0002-4959-4220"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiko Shien","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053681014","display_name":"Dennis Ruder","orcid":"https://orcid.org/0000-0001-7605-111X","observed_orcids":["https://orcid.org/0000-0001-7605-111X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Ruder","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112183049","display_name":"Ecaterina E. Ileana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ecaterina E. Ileana","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008790176","display_name":"Vassiliki A. Papadimitrakopoulou","orcid":"https://orcid.org/0000-0003-3172-1399","observed_orcids":["https://orcid.org/0000-0003-3172-1399"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vassiliki A. Papadimitrakopoulou","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071731260","display_name":"Garrett Michael Frampton","orcid":"https://orcid.org/0000-0002-2361-2750","observed_orcids":["https://orcid.org/0000-0002-2361-2750"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett M. Frampton","raw_affiliation_strings":["2Foundation Medicine Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105122","display_name":"Carmen Behrens","orcid":"https://orcid.org/0000-0003-1905-8061","observed_orcids":["https://orcid.org/0000-0003-1905-8061"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Behrens","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103148045","display_name":"Neda Kalhor","orcid":"https://orcid.org/0000-0001-6891-6435","observed_orcids":["https://orcid.org/0000-0001-6891-6435"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Kalhor","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Jack Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jack Lee","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023062017","display_name":"Ximing Tang","orcid":"https://orcid.org/0000-0001-6534-6852","observed_orcids":["https://orcid.org/0000-0001-6534-6852"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ximing Tang","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":["3Yale Cancer Center, Yale School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Yale Cancer Center, Yale School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028085268","display_name":"Ignacio Ivan Wistuba","orcid":"https://orcid.org/0000-0003-3365-6340","observed_orcids":["https://orcid.org/0000-0003-3365-6340"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacio I. Wistuba","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108617500","display_name":"Julie G. Izzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie G. Izzo","raw_affiliation_strings":["1MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"1144","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/eml4-alk-fusion","display_name":"EML4-ALK fusion","score":0.8679999709129333},{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tyrosine-kinase-oncogenes","display_name":"tyrosine kinase oncogenes","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.9400583505630493},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.9272956848144531},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.7163606286048889},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6647817492485046},{"id":"https://openalex.org/C2778347629","wikidata":"https://www.wikidata.org/wiki/Q4652380","display_name":"ALK inhibitor","level":5,"score":0.6480553150177002},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6370049715042114},{"id":"https://openalex.org/C2779220645","wikidata":"https://www.wikidata.org/wiki/Q21099132","display_name":"Alectinib","level":5,"score":0.5565739870071411},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5525752902030945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4567275643348694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29773667454719543},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.288937509059906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27198225259780884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23982089757919312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1774553656578064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09622648358345032},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.06274744868278503}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-1144","doi":"https://doi.org/10.1158/1538-7445.am2016-1144","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1144","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3119084223","https://openalex.org/W3120976032","https://openalex.org/W4394986746","https://openalex.org/W2133950886","https://openalex.org/W2923211459","https://openalex.org/W2016009621","https://openalex.org/W4385485761","https://openalex.org/W4214899588","https://openalex.org/W4241025674","https://openalex.org/W2783889408"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Anaplastic":[2],"lymphoma":[3],"kinase":[4,9],"(ALK)":[5],"is":[6,11,37,47,79],"a":[7,15,25,48,154,203,255,264],"tyrosine":[8],"that":[10,198],"constitutively":[12],"activated":[13],"in":[14,64,115,130,153,207,260],"subset":[16],"of":[17,27,35,45,58,112,127,157,167,213,254,271,276],"non-small":[18],"cell":[19],"lung":[20,155,208,261],"cancer":[21],"(NSCLC),":[22],"mainly":[23],"as":[24],"result":[26],"chromosomal":[28],"translocation.":[29],"In":[30,82,134],"ALK-rearranged":[31,168],"NSCLC,":[32,65],"the":[33,67,120,178,272,277],"growth":[34],"tumors":[36],"strongly":[38],"addicted":[39],"to":[40,69,73,96,174],"ALK":[41,46,59,70,100,141,149,163,185,214,257],"activity,":[42],"and":[43,103,109,146,188,210],"suppression":[44],"potent":[49],"therapeutic":[50],"strategy.":[51],"To":[52],"date,":[53],"6":[54],"known":[55],"fusion":[56,74,142,150,200,258],"partners":[57],"onco-kinase":[60],"have":[61],"been":[62],"reported":[63],"although":[66],"sensitivity":[68],"inhibitor":[71,186,215],"according":[72],"variant":[75,151,259],"except":[76],"for":[77,280],"EML4-ALK":[78,145],"still":[80],"unclear.":[81],"this":[83],"study,":[84],"we":[85],"reviewed":[86,106],"clinical":[87,113,125],"trial":[88,126],"samples":[89,114,139,169],"analyzed":[90],"by":[91],"comprehensive":[92,265],"genomic":[93,266],"profiling":[94],"approach":[95],"detect":[97],"unknown":[98],"actionable":[99],"rearrangements.":[101],"Materials":[102],"methods:":[104],"We":[105],"gene":[107,164],"alteration":[108],"expression":[110,165],"profile":[111],"preliminary":[116],"molecular":[117],"studies":[118],"from":[119],"ongoing":[121],"BATTLE-2,":[122],"phase":[123],"II":[124],"targeted":[128],"drugs":[129],"chemo-refractory":[131],"NSCLC.":[132],"Results:":[133],"187":[135],"NSCLC":[136],"samples,":[137],"3":[138],"harbored":[140],"gene:":[143],"2":[144],"1":[147],"novel":[148,204,256],"PRKAR1A-ALK":[152,181,199],"adenocarcinoma":[156,209,262],"male":[158],"former":[159],"smoker":[160],"patient.":[161],"The":[162],"levels":[166],"were":[170],"significantly":[171],"higher":[172],"compared":[173],"other":[175],"samples.":[176],"Interestingly,":[177],"patient":[179],"harboring":[180],"was":[182],"treated":[183],"with":[184],"crizotinib":[187],"showed":[189],"long":[190],"time":[191],"stable":[192],"disease.":[193],"Conclusions:":[194],"Our":[195],"findings":[196],"suggest":[197],"could":[201],"be":[202],"oncogenic":[205],"driver":[206],"an":[211],"indicator":[212],"response.":[216],"(NHI-NCI":[217],"CA155196;":[218],"2P50CA070907-16A1)":[219],"Citation":[220],"Format:":[221],"Kazuhiko":[222],"Shien,":[223],"Dennis":[224],"Ruder,":[225],"Ecaterina":[226],"E.":[227],"Ileana,":[228],"Vassiliki":[229],"A.":[230],"Papadimitrakopoulou,":[231],"Garrett":[232],"M.":[233],"Frampton,":[234],"Carmen":[235],"Behrens,":[236],"Neda":[237],"Kalhor,":[238],"J.":[239],"Jack":[240],"Lee,":[241],"Ximing":[242],"Tang,":[243],"Roy":[244],"S.":[245],"Herbst,":[246],"Ignacio":[247],"I.":[248],"Wistuba,":[249],"Julie":[250],"G.":[251],"Izzo.":[252],"Detection":[253],"using":[263],"analysis.":[267],"[abstract].":[268],"In:":[269],"Proceedings":[270],"107th":[273],"Annual":[274],"Meeting":[275],"American":[278],"Association":[279],"Cancer":[281,292],"Research;":[282],"2016":[283],"Apr":[284],"16-20;":[285],"New":[286],"Orleans,":[287],"LA.":[288],"Philadelphia":[289],"(PA):":[290],"AACR;":[291],"Res":[293],"2016;76(14":[294],"Suppl):Abstract":[295],"nr":[296],"1144.":[297]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-08-23T00:00:00"}