{"id":"https://openalex.org/W2482360682","doi":"https://doi.org/10.3389/fonc.2016.00181","title":"Targeting p97 to Disrupt Protein Homeostasis in Cancer","display_name":"Targeting p97 to Disrupt Protein Homeostasis in Cancer","publication_year":2016,"publication_date":"2016-08-03","ids":{"openalex":"https://openalex.org/W2482360682","doi":"https://doi.org/10.3389/fonc.2016.00181","mag":"2482360682","pmid":"https://pubmed.ncbi.nlm.nih.gov/27536557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4971439"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2016.00181","doi":"https://doi.org/10.3389/fonc.2016.00181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2016.00181","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2016.00181/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2016.00181/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048692218","display_name":"Pratikkumar Vekaria","orcid":"https://orcid.org/0000-0002-2379-5980","observed_orcids":["https://orcid.org/0000-0002-2379-5980"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratikkumar Harsukhbhai Vekaria","raw_affiliation_strings":["Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078154875","display_name":"Trisha Home","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha Home","raw_affiliation_strings":["Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002299630","display_name":"Scott James Weir","orcid":"https://orcid.org/0000-0002-8020-434X","observed_orcids":["https://orcid.org/0000-0002-8020-434X"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Weir","raw_affiliation_strings":["The University of Kansas Cancer Center, University of Kansas, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Kansas Cancer Center, University of Kansas, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049300475","display_name":"Frank J. Schoenen","orcid":"https://orcid.org/0000-0003-2711-1117","observed_orcids":["https://orcid.org/0000-0003-2711-1117"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank J. Schoenen","raw_affiliation_strings":["Specialized Chemistry Center, University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Chemistry Center, University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077507982","display_name":"Rekha Rao","orcid":"https://orcid.org/0000-0002-1873-8738","observed_orcids":["https://orcid.org/0000-0002-1873-8738"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rekha Rao","raw_affiliation_strings":["Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematologic Malignancies and Cellular Therapeutics, Kansas University Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077507982"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.6343,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.54371166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":null,"first_page":"181","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valosin-containing-protein","display_name":"VCP","score":0.9909999966621399},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/proteotoxic-stress","display_name":"proteotoxic stress","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5260000228881836},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8510000109672546},{"id":"https://openalex.org/keywords/retrotranslocation","display_name":"retrotranslocation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/misfolded-protein-degradation","display_name":"misfolded protein degradation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7699999809265137},{"id":"https://openalex.org/keywords/secretory-phenotype","display_name":"secretory phenotype","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6353859305381775},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5953140258789062},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5761547088623047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5439093708992004},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.520456075668335},{"id":"https://openalex.org/C101635128","wikidata":"https://www.wikidata.org/wiki/Q4649768","display_name":"AAA proteins","level":4,"score":0.47183969616889954},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4703284204006195},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4217420816421509},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.41686898469924927},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41097351908683777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22002512216567993},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.1688930094242096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09944775700569153},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08836793899536133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07924234867095947},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2016.00181","doi":"https://doi.org/10.3389/fonc.2016.00181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2016.00181","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2016.00181/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4971439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4971439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:27536557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27536557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7d876951f5ef49a0838204e7704598f3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d876951f5ef49a0838204e7704598f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 6 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2016.00181","doi":"https://doi.org/10.3389/fonc.2016.00181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2016.00181","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2016.00181/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000911857","display_name":"The University of Kansas Cancer Center","funder_award_id":"P30CA168524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2482360682.pdf","grobid_xml":"https://content.openalex.org/works/W2482360682.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W97697689","https://openalex.org/W375413697","https://openalex.org/W1528145391","https://openalex.org/W1543159299","https://openalex.org/W1597334704","https://openalex.org/W1926741013","https://openalex.org/W1962326359","https://openalex.org/W1965727325","https://openalex.org/W1965883471","https://openalex.org/W1966526764","https://openalex.org/W1968486675","https://openalex.org/W1970658265","https://openalex.org/W1974031565","https://openalex.org/W1974256456","https://openalex.org/W1984221986","https://openalex.org/W1985286323","https://openalex.org/W1989096291","https://openalex.org/W1989768108","https://openalex.org/W1991989590","https://openalex.org/W1993912244","https://openalex.org/W1994963031","https://openalex.org/W1996383226","https://openalex.org/W1997559284","https://openalex.org/W1998079027","https://openalex.org/W2000929246","https://openalex.org/W2003079343","https://openalex.org/W2006454434","https://openalex.org/W2007594173","https://openalex.org/W2010862596","https://openalex.org/W2011754116","https://openalex.org/W2012166934","https://openalex.org/W2014268728","https://openalex.org/W2017764563","https://openalex.org/W2018753611","https://openalex.org/W2022531767","https://openalex.org/W2023724382","https://openalex.org/W2032565934","https://openalex.org/W2033088972","https://openalex.org/W2038794428","https://openalex.org/W2040551057","https://openalex.org/W2044353042","https://openalex.org/W2045151558","https://openalex.org/W2045878597","https://openalex.org/W2047455709","https://openalex.org/W2049512057","https://openalex.org/W2056730111","https://openalex.org/W2058252917","https://openalex.org/W2059526410","https://openalex.org/W2066107559","https://openalex.org/W2067911054","https://openalex.org/W2068306128","https://openalex.org/W2073337768","https://openalex.org/W2074471441","https://openalex.org/W2077813812","https://openalex.org/W2078021348","https://openalex.org/W2079939478","https://openalex.org/W2080378383","https://openalex.org/W2081104776","https://openalex.org/W2081731224","https://openalex.org/W2083848910","https://openalex.org/W2088226484","https://openalex.org/W2091276600","https://openalex.org/W2102706169","https://openalex.org/W2104749531","https://openalex.org/W2114360920","https://openalex.org/W2115093402","https://openalex.org/W2116119295","https://openalex.org/W2120193453","https://openalex.org/W2123632489","https://openalex.org/W2125542684","https://openalex.org/W2126753299","https://openalex.org/W2127639686","https://openalex.org/W2127772281","https://openalex.org/W2127906377","https://openalex.org/W2128761802","https://openalex.org/W2133190342","https://openalex.org/W2135513925","https://openalex.org/W2139145543","https://openalex.org/W2142743332","https://openalex.org/W2149369491","https://openalex.org/W2150092941","https://openalex.org/W2151445954","https://openalex.org/W2152351845","https://openalex.org/W2155015733","https://openalex.org/W2156739666","https://openalex.org/W2157057023","https://openalex.org/W2161696113","https://openalex.org/W2168838455","https://openalex.org/W2214997168","https://openalex.org/W2220518990","https://openalex.org/W2227146331","https://openalex.org/W2258557438","https://openalex.org/W2259068415","https://openalex.org/W2261826202","https://openalex.org/W2262506123","https://openalex.org/W2263498456","https://openalex.org/W2330570783","https://openalex.org/W2340545341","https://openalex.org/W2346640814","https://openalex.org/W2347158091","https://openalex.org/W2430786080","https://openalex.org/W3133907395","https://openalex.org/W6670876847","https://openalex.org/W6678597336","https://openalex.org/W7099534335"],"related_works":["https://openalex.org/W4414157262","https://openalex.org/W1850011235","https://openalex.org/W2045440634","https://openalex.org/W2196544076","https://openalex.org/W1585645071","https://openalex.org/W2156739666","https://openalex.org/W2790656775","https://openalex.org/W4315874231","https://openalex.org/W2555716956","https://openalex.org/W3201649473"],"abstract_inverted_index":{"Cancer":[0],"cells":[1,26],"are":[2],"addicted":[3],"to":[4,11,28,68,142],"numerous":[5],"non-oncogenic":[6,18],"traits":[7],"that":[8,20,110],"enable":[9],"them":[10],"thrive.":[12],"Proteotoxic":[13],"stress":[14],"is":[15,21,61,66],"one":[16],"such":[17],"trait":[19],"experienced":[22],"by":[23],"all":[24],"tumor":[25],"owing":[27],"increased":[29],"genomic":[30],"abnormalities":[31],"and":[32,36,131],"the":[33,47,73,79,85,123],"resulting":[34],"synthesis":[35],"accumulation":[37],"of":[38,41,49,92,122,125],"non-stoichiometric":[39],"amounts":[40,48],"cellular":[42,88],"proteins.":[43,94],"This":[44,116],"imbalance":[45],"in":[46,53,72,76,105,127],"proteins":[50],"ultimately":[51],"culminates":[52],"proteotoxic":[54],"stress.":[55],"p97,":[56],"or":[57],"valosin-containing":[58],"protein":[59,70,129],"(VCP),":[60],"an":[62,139],"ATPase":[63],"whose":[64],"function":[65,124],"essential":[67],"restore":[69],"homeostasis":[71,130],"cells.":[74,145],"Working":[75],"concert":[77],"with":[78,134],"ubiquitin":[80],"proteasome":[81],"system,":[82],"p97":[83,96,126],"promotes":[84],"retrotranslocation":[86],"from":[87],"organelles":[89],"and/or":[90],"degradation":[91],"misfolded":[93],"Consequently,":[95],"inhibition":[97,133],"has":[98],"emerged":[99],"as":[100,138],"a":[101,112],"novel":[102],"therapeutic":[103],"target":[104,143],"cancer":[106,144],"cells,":[107],"especially":[108],"those":[109],"have":[111],"highly":[113],"secretory":[114],"phenotype.":[115],"review":[117],"summarizes":[118],"our":[119],"current":[120],"understanding":[121],"maintaining":[128],"its":[132],"small":[135],"molecule":[136],"inhibitors":[137],"emerging":[140],"strategy":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-08-23T00:00:00"}
