{"id":"https://openalex.org/W2481389108","doi":"https://doi.org/10.1016/j.virol.2016.06.023","title":"Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells","display_name":"Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells","publication_year":2016,"publication_date":"2016-07-13","ids":{"openalex":"https://openalex.org/W2481389108","doi":"https://doi.org/10.1016/j.virol.2016.06.023","mag":"2481389108","pmid":"https://pubmed.ncbi.nlm.nih.gov/27414250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079758"},"language":"en","primary_location":{"id":"doi:10.1016/j.virol.2016.06.023","doi":"https://doi.org/10.1016/j.virol.2016.06.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2016.06.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682216301647/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0042682216301647/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103534509","display_name":"Steven Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Santos","raw_affiliation_strings":["George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079320099","display_name":"Yuri Obukhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Obukhov","raw_affiliation_strings":["Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA; Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA","Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA; Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025205189","display_name":"Sergei A. Nekhai","orcid":"https://orcid.org/0000-0003-0744-7887","observed_orcids":["https://orcid.org/0000-0003-0744-7887"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Nekhai","raw_affiliation_strings":["Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA; Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA","Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA; Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Howard University College of Medicine, Department of Medicine, Center for Sickle Cell Disease, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Howard University College of Medicine, RCMI Proteomics Core Facility, 1840 7th Street N.W., Washington DC 20001, USA","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001400082","display_name":"Tatiana Pushkarsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Pushkarsky","raw_affiliation_strings":["George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039530369","display_name":"Beda B\u0159ich\u00e1\u010dek","orcid":"https://orcid.org/0000-0001-5864-4341","observed_orcids":["https://orcid.org/0000-0001-5864-4341"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beda Brichacek","raw_affiliation_strings":["George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068425146","display_name":"Michael Bukrinsky","orcid":"https://orcid.org/0000-0002-8593-0770","observed_orcids":["https://orcid.org/0000-0002-8593-0770"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Bukrinsky","raw_affiliation_strings":["George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA. Electronic address: mbukrins@gwu.edu","George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA. Electronic address: mbukrins@gwu.edu","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066916338","display_name":"Sergey Iordanskiy","orcid":"https://orcid.org/0000-0002-9279-8755","observed_orcids":["https://orcid.org/0000-0002-9279-8755"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Iordanskiy","raw_affiliation_strings":["George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine and Health Sciences, Department of Microbiology, Immunology and Tropical Medicine, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068425146"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":{"value":3160,"currency":"USD","value_usd":3160},"fwci":0.2305,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68284742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"497","issue":null,"first_page":"11","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcm5","display_name":"MCM5","score":0.9380000233650208},{"id":"https://openalex.org/keywords/minichromosome-maintenance-complex","display_name":"minichromosome maintenance complex","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hiv-1-virions","display_name":"HIV-1 virions","score":0.878000020980835},{"id":"https://openalex.org/keywords/viral-core-protein","display_name":"viral core protein","score":0.35600000619888306},{"id":"https://openalex.org/keywords/gag-protein","display_name":"Gag protein","score":0.8550000190734863},{"id":"https://openalex.org/keywords/reverse-transcription","display_name":"reverse transcription","score":0.8820000290870667},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5839999914169312},{"id":"https://openalex.org/keywords/host-factors-in-viral-infection","display_name":"host factors in viral infection","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8913604021072388},{"id":"https://openalex.org/C2780091387","wikidata":"https://www.wikidata.org/wiki/Q6865201","display_name":"Minichromosome","level":4,"score":0.7386716604232788},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6441059708595276},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6268913745880127},{"id":"https://openalex.org/C175248279","wikidata":"https://www.wikidata.org/wiki/Q3858415","display_name":"Minichromosome maintenance","level":5,"score":0.6224938035011292},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6059074401855469},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5537072420120239},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5369353890419006},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.505132257938385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.443763792514801},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43882089853286743},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4243134558200836},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3556404709815979},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3515053987503052},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.330214262008667},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.261288583278656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18245282769203186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12184873223304749},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09161689877510071},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.virol.2016.06.023","doi":"https://doi.org/10.1016/j.virol.2016.06.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2016.06.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682216301647/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},{"id":"pmid:27414250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27414250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4026021","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079758","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5079758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Virology","raw_type":"Text"},{"id":"pmh:oai:dh.howard.edu:sicklecell_fac-1036","doi":null,"is_oa":false,"landing_page_url":"https://dh.howard.edu/sicklecell_fac/37","pdf_url":null,"source":{"id":"https://openalex.org/S4377196566","display_name":"Digital Howard (Howard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137853757","host_organization_name":"Howard University","host_organization_lineage":["https://openalex.org/I137853757"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Center For Sickle Cell Disease Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.virol.2016.06.023","doi":"https://doi.org/10.1016/j.virol.2016.06.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2016.06.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682216301647/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1120747478","display_name":"The District of Columbia Developmental Center for AIDS Research (DC D-CFAR)","funder_award_id":"P30AI087714","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3608974278","display_name":null,"funder_award_id":"AI117970","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4481490527","display_name":"Computational Biology, Bioinformatics, Imaging & Proteomics Research-RCMI","funder_award_id":"G12RR003048","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4836122921","display_name":null,"funder_award_id":"RCMI-NIH 2G12RR003048","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5374675963","display_name":null,"funder_award_id":"AI117970","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G5577749326","display_name":null,"funder_award_id":"P30 AI117970","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G6714156533","display_name":null,"funder_award_id":"HIV-1","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000273067","display_name":null,"funder_award_id":"AI117970","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000860964","display_name":"District of Columbia Center for AIDS Research","funder_award_id":"P30AI117970","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309515","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2481389108.pdf","grobid_xml":"https://content.openalex.org/works/W2481389108.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W90995244","https://openalex.org/W174464755","https://openalex.org/W1517131856","https://openalex.org/W1726325960","https://openalex.org/W1856653403","https://openalex.org/W1964061454","https://openalex.org/W1964567249","https://openalex.org/W1977135599","https://openalex.org/W1982537658","https://openalex.org/W1985087864","https://openalex.org/W1985700039","https://openalex.org/W1994195473","https://openalex.org/W1996938063","https://openalex.org/W2003200194","https://openalex.org/W2003425131","https://openalex.org/W2018549259","https://openalex.org/W2020296890","https://openalex.org/W2027302473","https://openalex.org/W2033631070","https://openalex.org/W2036182382","https://openalex.org/W2037525015","https://openalex.org/W2040059091","https://openalex.org/W2040311458","https://openalex.org/W2040894241","https://openalex.org/W2045183567","https://openalex.org/W2045605961","https://openalex.org/W2047623219","https://openalex.org/W2050598058","https://openalex.org/W2060771896","https://openalex.org/W2062639699","https://openalex.org/W2067336798","https://openalex.org/W2069554621","https://openalex.org/W2077564249","https://openalex.org/W2084938297","https://openalex.org/W2085489729","https://openalex.org/W2088279551","https://openalex.org/W2088335428","https://openalex.org/W2096984734","https://openalex.org/W2099960858","https://openalex.org/W2100064182","https://openalex.org/W2103162105","https://openalex.org/W2108221620","https://openalex.org/W2114070092","https://openalex.org/W2119104567","https://openalex.org/W2119590927","https://openalex.org/W2122523609","https://openalex.org/W2122833547","https://openalex.org/W2123998497","https://openalex.org/W2124151594","https://openalex.org/W2126940472","https://openalex.org/W2128620821","https://openalex.org/W2128637595","https://openalex.org/W2129088762","https://openalex.org/W2130083472","https://openalex.org/W2132618997","https://openalex.org/W2134618734","https://openalex.org/W2144101850","https://openalex.org/W2149687756","https://openalex.org/W2150469985","https://openalex.org/W2152550969","https://openalex.org/W2152580066","https://openalex.org/W2161534592"],"related_works":["https://openalex.org/W2165124171","https://openalex.org/W3092270865","https://openalex.org/W2249435415","https://openalex.org/W2745195325","https://openalex.org/W7098200032","https://openalex.org/W2158052770","https://openalex.org/W3119306681","https://openalex.org/W1550872944","https://openalex.org/W1978909186","https://openalex.org/W2149566197"],"abstract_inverted_index":{"The":[0,57],"post-entry":[1],"events":[2],"of":[3,38,61,83,105,108,118,136,144],"HIV-1":[4,20,55],"infection":[5],"occur":[6],"within":[7],"reverse":[8,65,92,112,127],"transcription":[9,66,128],"complexes":[10],"derived":[11],"from":[12,26],"the":[13,17,39,86,134],"viral":[14,96],"cores":[15,21],"entering":[16],"target":[18],"cell.":[19],"contain":[22],"host":[23],"proteins":[24],"incorporated":[25,53],"virus-producing":[27],"cells.":[28],"In":[29],"this":[30],"report,":[31],"we":[32],"show":[33],"that":[34,103,140],"MCM5,":[35],"a":[36],"subunit":[37],"hexameric":[40],"minichromosome":[41],"maintenance":[42],"(MCM)":[43],"DNA":[44],"helicase":[45],"complex,":[46],"associates":[47],"with":[48,142],"Gag":[49],"polyprotein":[50],"and":[51,73,129],"is":[52],"into":[54,85],"virions.":[56],"progeny":[58],"virions":[59,87],"depleted":[60],"MCM5":[62,84,109,122,132],"demonstrated":[63],"reduced":[64,91,126],"in":[67],"newly":[68],"infected":[69],"cells,":[70],"but":[71,94],"integration":[72],"subsequent":[74],"replication":[75,97],"steps":[76],"were":[77],"not":[78],"affected.":[79],"Interestingly,":[80],"increased":[81,121],"packaging":[82],"also":[88],"led":[89],"to":[90,115,125],"transcription,":[93,113],"here":[95],"was":[98],"impaired.":[99],"Our":[100],"data":[101],"suggest":[102],"incorporation":[104],"physiological":[106],"amounts":[107],"promotes":[110],"aberrant":[111],"leading":[114],"partial":[116],"incapacitation":[117],"cDNA,":[119],"whereas":[120],"abundance":[123],"leads":[124],"infection.":[130],"Therefore,":[131],"has":[133],"properties":[135],"an":[137,145],"inhibitory":[138],"factor":[139],"interferes":[141],"production":[143],"integration-competent":[146],"cDNA":[147],"product.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-08-23T00:00:00"}