{"id":"https://openalex.org/W2481358170","doi":"https://doi.org/10.3892/ol.2016.4957","title":"Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-\u03baB signaling in murine breast cancer cells","display_name":"Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-\u03baB signaling in murine breast cancer cells","publication_year":2016,"publication_date":"2016-08-05","ids":{"openalex":"https://openalex.org/W2481358170","doi":"https://doi.org/10.3892/ol.2016.4957","mag":"2481358170","pmid":"https://pubmed.ncbi.nlm.nih.gov/27703525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5038907"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2016.4957","doi":"https://doi.org/10.3892/ol.2016.4957","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2016.4957","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2016.4957/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2016.4957/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029459501","display_name":"Ying Xin Xu","orcid":"https://orcid.org/0000-0001-9570-8666","observed_orcids":["https://orcid.org/0000-0001-9570-8666"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110839081","display_name":"Dongming Wu","orcid":"https://orcid.org/0000-0002-0665-4422","observed_orcids":["https://orcid.org/0000-0002-0665-4422"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongming Wu","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042070294","display_name":"Yuanchun Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanchun Fan","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012681814","display_name":"Peigeng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peigeng Li","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057941591","display_name":"Hongfei Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongfei Du","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiao Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Shi","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709844","display_name":"Dan Wang","orcid":"https://orcid.org/0000-0001-9079-2360","observed_orcids":["https://orcid.org/0000-0001-9079-2360"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Wang","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100687817","display_name":"Xiaoping Zhou","orcid":"https://orcid.org/0000-0003-0337-1731","observed_orcids":["https://orcid.org/0000-0003-0337-1731"]},"institutions":[{"id":"https://openalex.org/I4210127266","display_name":"First Affiliated Hospital of Chengdu Medical College","ror":"https://ror.org/03jckbw05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127266"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Zhou","raw_affiliation_strings":["Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I4210127266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029459501"],"corresponding_institution_ids":["https://openalex.org/I4210127266"],"apc_list":null,"apc_paid":null,"fwci":0.2892,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65396187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"4","first_page":"2632","last_page":"2640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-radiosensitivity","display_name":"tumor radiosensitivity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9419999718666077},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9240000247955322},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.9290000200271606},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.9136465191841125},{"id":"https://openalex.org/C38117629","wikidata":"https://www.wikidata.org/wiki/Q24788421","display_name":"Flagellin","level":3,"score":0.7400472164154053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7013522386550903},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6275819540023804},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.554460346698761},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5389419794082642},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4566667377948761},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.455710232257843},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4157615005970001},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.22155854105949402},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1961948275566101},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17435288429260254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12250801920890808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09929230809211731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07946121692657471}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/ol.2016.4957","doi":"https://doi.org/10.3892/ol.2016.4957","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2016.4957","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2016.4957/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5038907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5038907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"},{"id":"pmid:27703525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27703525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ol.2016.4957","doi":"https://doi.org/10.3892/ol.2016.4957","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2016.4957","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2016.4957/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4884469467","display_name":"\u4e73\u9178\u4e73\u7403\u83cc\u9012\u5448\u7684\u55dc\u80ba\u519b\u56e2\u83cc\u65b0\u578bFlaA/MompS\u75ab\u82d7\u7684\u6784\u5efa\u548c\u514d\u75ab\u6548\u5e94\u7814\u7a76","funder_award_id":"81001345","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2481358170.pdf","grobid_xml":"https://content.openalex.org/works/W2481358170.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W294885632","https://openalex.org/W1691733221","https://openalex.org/W1757407923","https://openalex.org/W1969106494","https://openalex.org/W1986231077","https://openalex.org/W1992303132","https://openalex.org/W1994613212","https://openalex.org/W2008058116","https://openalex.org/W2013383578","https://openalex.org/W2024457133","https://openalex.org/W2028040595","https://openalex.org/W2035662091","https://openalex.org/W2044348405","https://openalex.org/W2059738518","https://openalex.org/W2069393038","https://openalex.org/W2070692423","https://openalex.org/W2070860179","https://openalex.org/W2084014075","https://openalex.org/W2087582854","https://openalex.org/W2095233665","https://openalex.org/W2110734483","https://openalex.org/W2110864471","https://openalex.org/W2112637372","https://openalex.org/W2128705539","https://openalex.org/W2128955440","https://openalex.org/W2134647795","https://openalex.org/W2151576881","https://openalex.org/W2151585080","https://openalex.org/W2152007168","https://openalex.org/W2152939296","https://openalex.org/W2153065589","https://openalex.org/W2153988674","https://openalex.org/W2155901289","https://openalex.org/W2157044423","https://openalex.org/W2158615473","https://openalex.org/W2158860532","https://openalex.org/W2158892689","https://openalex.org/W2165035535","https://openalex.org/W2166274230","https://openalex.org/W2168234685","https://openalex.org/W2194359049","https://openalex.org/W2239009816","https://openalex.org/W2275670149","https://openalex.org/W2474168903"],"related_works":["https://openalex.org/W2275670149","https://openalex.org/W2004456564","https://openalex.org/W2147644365","https://openalex.org/W2052597826","https://openalex.org/W7144852869","https://openalex.org/W2346599706","https://openalex.org/W2748749105","https://openalex.org/W2021757854","https://openalex.org/W2378055957","https://openalex.org/W2026158949"],"abstract_inverted_index":{",":[0],"has":[1,33],"been":[2],"shown":[3],"to":[4,74,96,119],"increase":[5,19,75,85],"the":[6,12,20,60,64,81,104,122],"expression":[7],"of":[8,22,67,125],"cytoprotective":[9],"cytokines,":[10],"activate":[11],"nuclear":[13],"factor-\u03baB":[14],"(NF-\u03baB)":[15],"signaling":[16],"pathway,":[17],"and":[18,78,84,114],"survival":[21,123],"mice":[23,126],"following":[24],"total":[25,128],"body":[26,129],"irradiation.":[27],"Determi":[28],"ning":[29],"whether":[30],"FlaA":[31,68,70,92,108,115,134],"N/C":[32,71,93,116,135],"a":[34,41,138],"sensitizing":[35],"effect":[36,44],"on":[37],"tumor":[38,65,76,89,143],"radiation":[39,53,140,144],"or":[40],"direct":[42],"tumoricidal":[43],"is":[45],"critical":[46],"for":[47],"its":[48],"application":[49],"as":[50],"an":[51],"effective":[52],"protection":[54],"agent.":[55],"The":[56],"present":[57,105],"study":[58,106],"investigated":[59],"molecular":[61],"mechanism":[62],"underlying":[63],"radiosensitivity":[66,86,98,110],"N/C.":[69],"was":[72,94,117],"found":[73,95,118],"apoptosis":[77],"autophagy,":[79],"regulate":[80],"cell":[82],"cycle":[83],"in":[87,111,142],"4T1":[88],"cells.":[90],"Furthermore,":[91],"promote":[97],"by":[99],"activating":[100],"NF-\u03baB":[101],"signaling.":[102],"Finally,":[103],"analyzed":[107],"N/C-enhanced":[109],"animal":[112],"models,":[113],"significantly":[120],"prolong":[121],"period":[124],"after":[127],"radiation.":[130],"This":[131],"indicates":[132],"that":[133],"might":[136],"be":[137],"novel":[139],"sensitizer":[141],"therapy.":[145]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-08-23T00:00:00"}
