{"id":"https://openalex.org/W248134471","doi":null,"title":"[A analysis of ELISA on the time-related expression of IL-2 and TNF-alpha during the healing process of wound in rat skin].","display_name":"[A analysis of ELISA on the time-related expression of IL-2 and TNF-alpha during the healing process of wound in rat skin].","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W248134471","mag":"248134471","pmid":"https://pubmed.ncbi.nlm.nih.gov/12725158"},"language":"zh","primary_location":{"id":"pmid:12725158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12725158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fa yi xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069606427","display_name":"\u738b\u6167\u541b","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-jun Wang","raw_affiliation_strings":["Department of Pathology, First Military Medical University, Guangzhou 510515"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, First Military Medical University, Guangzhou 510515","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017885646","display_name":"\u4e01\u4e91\u5ddd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-chuan Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3557,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61152032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"1","first_page":"10","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.949999988079071},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7559999823570251},{"id":"https://openalex.org/keywords/postmortem-injury","display_name":"postmortem injury","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2937138080596924}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:12725158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12725158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fa yi xue za zhi","raw_type":"English Abstract"},{"id":"mag:2346330915","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/Index/10045619-200302-19-1-10-12-a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2358866788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12725158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:248134471","doi":null,"is_oa":false,"landing_page_url":"http://www.fyxzz.cn/CN/abstract/abstract19955.shtml","pdf_url":null,"source":{"id":"https://openalex.org/S4306553676","display_name":"\u6cd5\u533b\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u6cd5\u533b\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2346330915","https://openalex.org/W158525991","https://openalex.org/W2252775084","https://openalex.org/W122018166","https://openalex.org/W7143966216","https://openalex.org/W787315570","https://openalex.org/W1024713993","https://openalex.org/W825812069","https://openalex.org/W1044916898","https://openalex.org/W897073853"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1],"order":[2],"to":[3,39,63,94],"explore":[4],"the":[5,8,14,18,41],"relationship":[6],"between":[7,96],"expression":[9,43,114],"change":[10],"of":[11,21,28,45,51,76],"cytokines":[12],"and":[13,53,69,78,88,99],"wound":[15],"age":[16],"during":[17,115],"healing":[19,117],"process":[20],"rats":[22],"skin":[23,34],"wound.":[24],"METHODS:":[25],"A":[26],"assay":[27],"ELISA":[29],"were":[30,81,92],"performed":[31],"on":[32],"intravital":[33],"wounds(after":[35],"incision":[36],"0.5-168":[37],"h)":[38],"detect":[40],"dynamics":[42],"level":[44,50,107],"IL-2,":[46],"TNF-alpha.":[47],"RESULTS:":[48],"The":[49,105],"IL-2":[52,79],"TNF-alpha":[54],"increased":[55],"at":[56,66,83],"0.5":[57],"h":[58,68,71,85,98,101],"after":[59,72,86,102],"wounding,":[60,87],"then":[61],"got":[62],"a":[64,112],"peak":[65],"3":[67],"1":[70],"injure":[73],"respectively.":[74],"Rebound":[75],"TNF":[77],"levels":[80,91],"shown":[82],"48":[84],"both":[89],"cytokine":[90,106],"inclined":[93],"elevating":[95],"72":[97],"168":[100],"wounding.":[103],"CONCLUSION:":[104],"changes":[108],"suggest":[109],"they":[110],"have":[111],"time-related":[113],"wounds":[116],"process.":[118]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}