{"id":"https://openalex.org/W2481294699","doi":"https://doi.org/10.1016/0960-894x(96)00175-8","title":"Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin","display_name":"Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2481294699","doi":"https://doi.org/10.1016/0960-894x(96)00175-8","mag":"2481294699"},"language":"en","primary_location":{"id":"doi:10.1016/0960-894x(96)00175-8","doi":"https://doi.org/10.1016/0960-894x(96)00175-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0960-894x(96)00175-8","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062840295","display_name":"V\u00e9ronique Leclerc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Leclerc","raw_affiliation_strings":["Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086670020","display_name":"Patrick Depreux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Depreux","raw_affiliation_strings":["Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035522540","display_name":"Daniel Lesieur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"D. Lesieur","raw_affiliation_strings":["Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Pharmaceutique, 3 rue du Professeur Laguesse, B.P. 83, 59006 LilleFrance fax : 19.33.20.96.43.61","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075639539","display_name":"Daniel\u2010Henri Caignard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.H. Caignard","raw_affiliation_strings":["ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107119292","display_name":"Pierre Renard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Renard","raw_affiliation_strings":["ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106426505","display_name":"Philippe Delagrange","orcid":"https://orcid.org/0000-0002-7456-0081","observed_orcids":["https://orcid.org/0000-0002-7456-0081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Delagrange","raw_affiliation_strings":["ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564214","display_name":"B.J. Lema\u00eetre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Guardiola-Lemaitre","raw_affiliation_strings":["ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADIR et Cie., 1 rue Carle H\u00e9bert, 92415 CourbevoieFrance fax : 19.33.16.1.46.41.60.11","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089854237","display_name":"Peter J. Morgan","orcid":"https://orcid.org/0000-0002-5071-6512","observed_orcids":["https://orcid.org/0000-0002-5071-6512"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Morgan","raw_affiliation_strings":["Rowett Research Institute, Aberdeen, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rowett Research Institute, Aberdeen, Scotland, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035522540"],"corresponding_institution_ids":["https://openalex.org/I2279609970"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.6955,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.73590096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"10","first_page":"1071","last_page":"1076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin-analogues","display_name":"melatonin analogues","score":0.9620000123977661},{"id":"https://openalex.org/keywords/conformationally-restricted-compounds","display_name":"conformationally restricted compounds","score":0.8009999990463257},{"id":"https://openalex.org/keywords/naphthalene","display_name":"naphthalene","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tetralin","display_name":"tetralin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pyrans","display_name":"pyrans","score":0.5320000052452087},{"id":"https://openalex.org/keywords/furan","display_name":"furan","score":0.9929999709129333},{"id":"https://openalex.org/keywords/1-4-dioxane","display_name":"1,4-dioxane","score":0.906000018119812},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.7490000128746033},{"id":"https://openalex.org/keywords/agonist-activity","display_name":"agonist activity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9046272039413452},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8295936584472656},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.632197916507721},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4923447370529175},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4536761939525604},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44017526507377625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35614240169525146},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33152860403060913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19346532225608826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0960-894x(96)00175-8","doi":"https://doi.org/10.1016/0960-894x(96)00175-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0960-894x(96)00175-8","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1972170987","https://openalex.org/W1979279168","https://openalex.org/W2007243418","https://openalex.org/W2032703049","https://openalex.org/W2059576405","https://openalex.org/W2073282842","https://openalex.org/W2079024439","https://openalex.org/W2085540910","https://openalex.org/W2089010636","https://openalex.org/W2090811969","https://openalex.org/W2092394577","https://openalex.org/W2094469738","https://openalex.org/W2109070785","https://openalex.org/W2313086118","https://openalex.org/W2314689292","https://openalex.org/W2315005057","https://openalex.org/W2318090527","https://openalex.org/W2331641372","https://openalex.org/W2586809587","https://openalex.org/W4297722843"],"related_works":["https://openalex.org/W2091595841","https://openalex.org/W2058965100","https://openalex.org/W2025732175","https://openalex.org/W2032703049","https://openalex.org/W2052266950","https://openalex.org/W2042989994","https://openalex.org/W2003048870","https://openalex.org/W2339612434","https://openalex.org/W2004367201","https://openalex.org/W2095074370"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-08-23T00:00:00"}
