{"id":"https://openalex.org/W2480966160","doi":null,"title":"A\u00e7\u00e3o tripanocida de um mastoparano de Polybia paulista e seu poss\u00edvel mecanismo de a\u00e7\u00e3o","display_name":"A\u00e7\u00e3o tripanocida de um mastoparano de Polybia paulista e seu poss\u00edvel mecanismo de a\u00e7\u00e3o","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2480966160","mag":"2480966160"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:1653664","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.ufc.br/handle/riufc/13766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da Universidade Federal do Cear\u00e1 (UFC)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.repositorio.ufc.br/handle/riufc/13766","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079516643","display_name":"Juliana Freire Chagas Vinhote","orcid":"https://orcid.org/0000-0003-4383-5270","observed_orcids":["https://orcid.org/0000-0003-4383-5270"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Juliana Freire Chagas Vinhote","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4383-5270","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079516643"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mastoparan","display_name":"mastoparan","score":0.8759999871253967},{"id":"https://openalex.org/keywords/polybia-paulista","display_name":"Polybia paulista","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9480000138282776},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antiparasitic-peptides","display_name":"antiparasitic peptides","score":0.6439999938011169},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7789999842643738},{"id":"https://openalex.org/keywords/epimastigotes","display_name":"epimastigotes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/trypomastigotes","display_name":"trypomastigotes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6100000143051147},{"id":"https://openalex.org/keywords/neglected-tropical-diseases","display_name":"neglected tropical diseases","score":0.6230000257492065},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.3109999895095825},{"id":"https://openalex.org/keywords/bioactive-peptides","display_name":"bioactive peptides","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.623814046382904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4773052930831909},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.4488978385925293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159458875656128},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.41258910298347473},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:americanae.aecid.es:1653664","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.ufc.br/handle/riufc/13766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da Universidade Federal do Cear\u00e1 (UFC)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.ufc.br:riufc/13766","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.ufc.br/handle/riufc/13766","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFC","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.teses.ufc.br:10180","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15376","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFC","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:1591772","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFC","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2480966160","doi":null,"is_oa":false,"landing_page_url":"http://www.repositorio.ufc.br/bitstream/riufc/13766/1/2015_tese_jfcvinhote.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1653664","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.ufc.br/handle/riufc/13766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da Universidade Federal do Cear\u00e1 (UFC)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7120646205","https://openalex.org/W2743248549","https://openalex.org/W3022439126","https://openalex.org/W7120779586","https://openalex.org/W7133414877","https://openalex.org/W7120548306","https://openalex.org/W7018789451","https://openalex.org/W2954829075","https://openalex.org/W2762066735","https://openalex.org/W7019182904"],"abstract_inverted_index":{"A":[0,249,385],"doen\u00c3a":[1,6],"de":[2,55,63,73,80,97,104,127,134,138,147,159,164,166,175,189,200,208,210,217,223,227,231,236,271,293,318,324,338,345,355,383,403,417,421,457,464,471],"Chagas,":[3],"considerada":[4],"uma":[5,9,322],"negligenciada,":[7],"\u00c3":[8,26],"infec\u00c3\u00c3o":[10,165],"parasit\u00c3ria":[11],"causada":[12],"pelo":[13,244],"Trypanosoma":[14,128],"cruzi":[15,129,140,161],"e":[16,46,130,149,154,177,212,257,297,329,335,428,453,466],"end\u00c3mica":[17],"em":[18,221,286,390,462],"diversos":[19],"pa\u00c3ses.":[20],"No":[21,269,401],"Brasil,":[22],"apenas":[23],"o":[24,29,35,101,111,234,265,313,365,407,442,475],"Benzonidazol":[25],"usado":[27],"para":[28,100,308,332],"tratamento":[30],"da":[31,50,78,120,215,283,343,367,426],"doen\u00c3a.":[32],"Nesse":[33],"contexto,":[34],"potencial":[36,235,366,456],"terap\u00c3utico":[37],"das":[38,186,239,315],"toxinas":[39],"vem":[40],"cada":[41],"vez":[42],"mais":[43,70],"conquistando":[44],"espa\u00c3o":[45],"despertando":[47],"grandes":[48],"interesses":[49],"comunidade":[51],"cient\u00c3fica.":[52],"Os":[53,66],"venenos":[54],"invertebrados":[56],"t\u00c3m":[57,91],"apresentado":[58],"grande":[59],"interesse":[60,93],"como":[61,95,479],"fonte":[62,96],"subst\u00c3ncias":[64],"bioativas.":[65],"mastoparanos,":[67],"a":[68,76,184,206,213,258,276,281,300,376,430,448,469],"classe":[69],"amplamente":[71],"descrita":[72],"pept\u00c3deos":[74,89],"isolados":[75,90],"partir":[77,282],"pe\u00c3onha":[79],"vespas,":[81],"ja":[82],"evidenciaram":[83],"diferentes":[84,145,173,398,415],"atividades":[85],"biol\u00c3gicas.":[86],"Assim,":[87],"os":[88,414,484],"despertado":[92],"cient\u00c3fico":[94],"modelos":[98],"moleculares":[99],"poss\u00c3vel":[102,132],"desenvolvimento":[103],"novas":[105],"terapias":[106],"farmacol\u00c3gicas.":[107],"Este":[108],"estudo":[109,270,402],"investigou":[110],"efeito":[112,193,230],"do":[113,118,195,279,303,370,387,409,423,450,455],"peptideo":[114,363],"mastoparano":[115,196,232,280,311,388,410,443,476],"(MP)":[116],"isolado":[117],"veneno":[119],"vespa":[121],"Polybia":[122],"paulista":[123],"sobre":[124,197,233,253],"cepa":[125],"Y":[126],"seu":[131],"mecanismo":[133],"a\u00c3\u00c3o.":[135],"Formas":[136,157],"epimastigotas":[137,199,241,317],"T.":[139,160,319,472],"foram":[141,169,203],"cultivadas,":[142],"tratadas":[143,171],"com":[144,172,205,246,267],"concentra\u00c3\u00c3es":[146,174,399],"MP":[148,176,211],"incubadas":[150,178,204],"durante":[151,179],"24,":[152,333],"48":[153,334],"72":[155,336],"horas.":[156,181],"tripomastigotas":[158,375],"obtidas":[162],"atrav\u00c3s":[163],"c\u00c3lulas":[167,463],"LLCMK2":[168],"subcultivadas,":[170],"24":[180],"Para":[182,372],"investigar":[183],"participa\u00c3\u00c3o":[185,449],"esp\u00c3cies":[187,346],"reativas":[188,347],"oxig\u00c3nio":[190],"(ERO)":[191],"no":[192],"citot\u00c3xico":[194],"formas":[198,240,316,374],"T.cruzi,":[201],"placas":[202],"CI50":[207,323,377],"24h":[209,382],"an\u00c3lise":[214,290,342],"emiss\u00c3o":[216],"fluoresc\u00c3ncia":[218],"foi":[219,242,251,262,306,378,405],"realizada":[220],"citometria":[222],"fluxo":[224],"ap\u00c3s":[225,381],"adi\u00c3\u00c3o":[226],"DCF.":[228],"O":[229,310,362],"membrana":[237,368,458],"mitocontrial":[238],"realizado":[243],"ensaio":[245,266],"rodamina":[247],"123.":[248],"citotoxicidade":[250],"avaliada":[252,389],"celulas":[254],"Raw":[255],"264.7":[256],"viabilidade":[259],"dos":[260,291,419],"macr\u00c3fagos":[261,391,465],"determinada":[263],"utilizando":[264],"MTT.":[268],"Docking":[272],"molecular,":[273],"obteve-se":[274],"inicialmente":[275],"estrutura":[277,301],"tridimensional":[278],"sequ\u00c3ncia":[284],"prim\u00c3ria":[285],"programa":[287],"espec\u00c3fico.":[288],"Ap\u00c3s":[289],"s\u00c3tios":[292,416],"liga\u00c3\u00c3o":[294,418],"entre":[295],"pept\u00c3deo":[296],"enzima":[298,427],"TcGAPDH,":[299,412],"cristalogr\u00c3fica":[302],"complexo":[304],"TcGAPDH-chalepina":[305],"utilizada":[307],"compara\u00c3\u00c3o.":[309],"inibiu":[312],"crescimento":[314],"cruzi,":[320],"apresentando":[321],"102":[325],"\u00c2g/mL,":[326],"53,95":[327],"\u00c2g/mL":[328,331,380],"58,51":[330],"horas":[337],"incuba\u00c3\u00c3o":[339],"respectivamente.":[340],"Na":[341],"produ\u00c3\u00c3o":[344],"houve":[348],"um":[349],"aumento":[350],"significativo":[351],"na":[352,411,432,438],"intensidade":[353],"relativa":[354],"fluoresc\u00c3ncia,":[356],"quando":[357],"comparado":[358],"ao":[359],"grupo":[360],"controle.":[361],"alterou":[364],"mitocondrial":[369],"parasita.":[371],"as":[373],"8,83":[379],"incuba\u00c3\u00c3o.":[384],"citotoxidade":[386],"n\u00c3o":[392],"induziu":[393],"morte":[394],"celular":[395],"significativa":[396],"nas":[397],"estudadas.":[400],"docking,":[404],"evidenciado":[406],"acoplamento":[408],"demonstrando":[413],"res\u00c3duos":[420],"amino\u00c3cidos":[422],"centro":[424],"ativo":[425],"comparando":[429],"semelhan\u00c3a":[431],"posi\u00c3\u00c3o":[433],"ocupada":[434],"pela":[435],"mol\u00c3cula":[436,481],"chalepina":[437],"TcGAPDH.":[439],"Conclui-se":[440],"que":[441],"apresentou":[444],"atividade":[445],"tripanocida":[446],"envolvendo":[447],"estresse":[451],"oxidativo":[452],"altera\u00c3\u00c3o":[454],"sem":[459],"apresentar":[460],"citot\u00c3xica":[461],"parece":[467],"inibir":[468],"TcGAPDH":[470],"cruzi.":[473],"Portanto,":[474],"se":[477],"destaca":[478],"importante":[480],"bioativa":[482],"contra":[483],"parasitas.":[485]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-08-23T00:00:00"}
