{"id":"https://openalex.org/W2480484873","doi":"https://doi.org/10.1055/s-0035-1544633","title":"Effects of 12 weeks of once-daily tiotropium and olodaterol fixed-dose combination on exercise endurance in patients with COPD","display_name":"Effects of 12 weeks of once-daily tiotropium and olodaterol fixed-dose combination on exercise endurance in patients with COPD","publication_year":2015,"publication_date":"2015-02-04","ids":{"openalex":"https://openalex.org/W2480484873","doi":"https://doi.org/10.1055/s-0035-1544633","mag":"2480484873"},"language":"en","primary_location":{"id":"doi:10.1055/s-0035-1544633","doi":"https://doi.org/10.1055/s-0035-1544633","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0035-1544633","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112143217","display_name":"AM Kirsten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140903","display_name":"LungenClinic Grosshansdorf","ror":"https://ror.org/041wfjw90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140903"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"AM Kirsten","raw_affiliation_strings":["Pulmonary Research Institute at Lungclinic Grosshansdorf, Airway Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Research Institute at Lungclinic Grosshansdorf, Airway Research Center","institution_ids":["https://openalex.org/I4210140903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110216511","display_name":"F. Maltais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F Maltais","raw_affiliation_strings":["Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec","institution_ids":["https://openalex.org/I4210135357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009185247","display_name":"J. G. Iturri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089430","display_name":"BioCruces Health research Institute","ror":"https://ror.org/0061s4v88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210089430"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JBG Iturri","raw_affiliation_strings":["Respiratory Function, BioCruces Health Research Institute, Barakaldo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Function, BioCruces Health Research Institute, Barakaldo","institution_ids":["https://openalex.org/I4210089430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Singh","raw_affiliation_strings":["Medicines Evaluation Unit, University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit, University of Manchester","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Hamilton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hamilton","raw_affiliation_strings":["Medical, Boehringer Ingelheim Burlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical, Boehringer Ingelheim Burlington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103038324","display_name":"Kay Tetzlaff","orcid":"https://orcid.org/0000-0003-1411-7640","observed_orcids":["https://orcid.org/0000-0003-1411-7640"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Tetzlaff","raw_affiliation_strings":["Respiratory Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG \u2013 Ingelheim; Department of Sports Medicine, University of T\u00fcbingen","Department of Sports Medicine, University of T\u00fcbingen","Respiratory Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG \u2013 Ingelheim"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG \u2013 Ingelheim; Department of Sports Medicine, University of T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Sports Medicine, University of T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Respiratory Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG \u2013 Ingelheim","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101599804","display_name":"Yanyan Zhao","orcid":"https://orcid.org/0000-0001-6294-9447","observed_orcids":["https://orcid.org/0000-0001-6294-9447"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Zhao","raw_affiliation_strings":["Biostatistics, Boehringer Ingelheim Pharmaceuticals Inc. Ridgefield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Boehringer Ingelheim Pharmaceuticals Inc. Ridgefield","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058532986","display_name":"Richard H. Casaburi","orcid":"https://orcid.org/0000-0002-8851-8589","observed_orcids":["https://orcid.org/0000-0002-8851-8589"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Casaburi","raw_affiliation_strings":["Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2357,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67063832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"69","issue":"S 01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiotropium","display_name":"tiotropium","score":0.9900000095367432},{"id":"https://openalex.org/keywords/olodaterol","display_name":"olodaterol","score":1.0},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/exercise-endurance","display_name":"exercise endurance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cycle-ergometry","display_name":"cycle ergometry","score":0.7879999876022339},{"id":"https://openalex.org/keywords/inspiratory-capacity","display_name":"inspiratory capacity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bronchodilator-therapy","display_name":"bronchodilator therapy","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7512363195419312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7346085906028748},{"id":"https://openalex.org/C2776623344","wikidata":"https://www.wikidata.org/wiki/Q5456317","display_name":"Fixed-dose combination","level":2,"score":0.6181759834289551},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45127880573272705},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4022178649902344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3116696774959564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0035-1544633","doi":"https://doi.org/10.1055/s-0035-1544633","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0035-1544633","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082855236","https://openalex.org/W2794058912","https://openalex.org/W2608963101","https://openalex.org/W2590468186","https://openalex.org/W4411415203","https://openalex.org/W2571336927","https://openalex.org/W2080505657","https://openalex.org/W2612788698","https://openalex.org/W2938202259","https://openalex.org/W2533747593"],"abstract_inverted_index":{"Background:":[0],"Both":[1,197],"tiotropium":[2],"(T)":[3],"and":[4,153],"olodaterol":[5],"(O)":[6],"monotherapies":[7],"improve":[8],"exercise":[9,29],"endurance":[10,30,80,96,149],"in":[11,31,109,173],"patients":[12,32,125],"with":[13,33,55,163],"chronic":[14],"obstructive":[15],"pulmonary":[16],"disease":[17],"(COPD).":[18],"Objective:":[19],"To":[20],"evaluate":[21],"the":[22],"effects":[23],"of":[24,112],"T+O":[25,62,164,181,198,215],"fixed-dose":[26],"combination":[27],"on":[28],"GOLD":[34,56],"2":[35,57],"\u2013":[36,58],"3":[37,59],"COPD":[38,60],"after":[39,91,103,151],"12":[40,92,104,154,170,186],"weeks.":[41,93,171],"Methods:":[42],"TORRACTO":[43],"(NCT01525615)":[44],"was":[45,79,106,138,160],"a":[46,110],"12-week,":[47],"double-blind,":[48],"parallel-group,":[49],"placebo-controlled,":[50],"Phase":[51],"III":[52],"study.":[53],"Patients":[54],"received":[61],"(5/5":[63],"or":[64,74],"2.5/5":[65],"\u00b5g)":[66],"once":[67],"daily":[68],"via":[69],"Respimat":[70],"Soft":[71],"Mist":[72],"inhaler,":[73],"placebo.":[75,224],"Primary":[76],"end":[77,116],"point":[78],"time":[81,150],"(ET)":[82],"during":[83,95,157,175,220],"constant":[84],"work-rate":[85],"cycle":[86,147,158,221],"ergometry":[87,148,159,222],"to":[88,100],"symptom":[89,101],"limitation":[90,102],"ET":[94,156,174,219],"shuttle":[97],"walking":[98],"(ESW)":[99],"weeks":[105,155,187],"also":[107],"assessed":[108],"subset":[111],"165":[113],"patients.":[114],"Other":[115],"points":[117],"included":[118],"pre-exercise":[119,201],"inspiratory":[120],"capacity":[121],"(IC).":[122],"Results:":[123],"404":[124],"(269":[126],"men)":[127],"were":[128,177,212],"randomised":[129],"(full":[130],"analysis":[131],"set":[132],"n=":[133],"385).":[134],"Mean":[135],"post-bronchodilator":[136],"FEV1":[137],"1.66":[139],"L":[140],"(58.6%":[141],"predicted).":[142],"Fig.":[143],"1:":[144],"Geometric":[145],"mean":[146],"6":[152],"significantly":[161],"increased":[162,200],"5/5":[165,216],"\u00b5g":[166,217],"vs":[167,183,203,223],"placebo":[168,184,204],"at":[169,185,229],"Increases":[172],"ESW":[176],"observed":[178],"for":[179,194],"both":[180],"doses":[182,199],"(21%":[188],"increase,":[189],"nominal":[190],"p":[191,206],"=":[192],"0.06":[193],"each":[195],"dose).":[196],"IC":[202],"(nominal":[205],"<":[207],"0.0005).":[208],"No":[209],"safety":[210],"concerns":[211],"identified.":[213],"Conclusions:":[214],"improved":[218],"Funding:":[225],"Boehringer":[226],"Ingelheim.":[227],"Presented":[228],"ERS":[230],"congress":[231],"2014":[232]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}