{"id":"https://openalex.org/W248035482","doi":null,"title":"Inosiplex: a novel treatment in rheumatoid arthritis?","display_name":"Inosiplex: a novel treatment in rheumatoid arthritis?","publication_year":1981,"publication_date":"1981-07-01","ids":{"openalex":"https://openalex.org/W248035482","mag":"248035482","pmid":"https://pubmed.ncbi.nlm.nih.gov/6170755"},"language":"en","primary_location":{"id":"pmid:6170755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6170755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086601121","display_name":"Joseph Wybran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wybran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109812212","display_name":"Jean Pierre Famaey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Famaey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111496216","display_name":"Thierry Appelboom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Appelboom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2806,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.776907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"4","first_page":"643","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inosiplex","display_name":"inosiplex","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.4620000123977661},{"id":"https://openalex.org/keywords/morning-stiffness","display_name":"morning stiffness","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tender-joint-count","display_name":"tender joint count","score":0.6520000100135803},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.9620000123977661},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9860000014305115},{"id":"https://openalex.org/keywords/disease-exacerbation","display_name":"disease exacerbation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9725779294967651},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8346610069274902},{"id":"https://openalex.org/C2909196033","wikidata":"https://www.wikidata.org/wiki/Q559210","display_name":"Morning stiffness","level":4,"score":0.7807130813598633},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.7488860487937927},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6334578990936279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6123409271240234},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.44632571935653687},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4443276524543762},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4222908020019531},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.41120922565460205},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36913275718688965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11530563235282898},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007288","descriptor_name":"Inosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007542","descriptor_name":"Inosine Pranobex","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:6170755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6170755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/91243","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/91243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of rheumatology, 8 (4","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:248035482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6170755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2154198285","https://openalex.org/W2395038369","https://openalex.org/W2392301678","https://openalex.org/W2061948993","https://openalex.org/W2083897127","https://openalex.org/W2471441309","https://openalex.org/W2912385517","https://openalex.org/W2412297691","https://openalex.org/W3124486170","https://openalex.org/W2439531772"],"abstract_inverted_index":{"In":[0],"an":[1,84],"open":[2],"study":[3,118],"inosiplex,":[4],"a":[5,38,68],"new":[6],"synthetic":[7],"immunomodulatory":[8],"drug,":[9],"was":[10,72,93],"given":[11],"to":[12,62],"15":[13,31],"patients":[14,32,59,82],"with":[15],"rheumatoid":[16],"arthritis":[17],"(RA)":[18],"3":[19],"g":[20],"daily":[21],"until":[22],"clinical":[23,34],"improvement":[24,71],"occurred":[25],"and":[26,51,55,67,110],"then":[27],"tapered.":[28],"Nine":[29],"of":[30,40,86,98,100,108,113,119,125],"experienced":[33],"benefit":[35],"evidenced":[36],"by":[37,77],"reduction":[39],"morning":[41],"stiffness,":[42],"fewer":[43],"tender":[44],"joints,":[45],"decreased":[46,52],"proximal":[47],"interphalangeal":[48],"joint":[49],"circumference,":[50],"sedimentation":[53],"rate":[54,112],"fibrinogen":[56],"level.":[57],"Three":[58],"responded":[60],"rapidly":[61,107],"inosiplex":[63,101],"(in":[64],"two":[65],"weeks)":[66],"clear":[69],"cut":[70],"noticed":[73],"within":[74],"1":[75],"month":[76],"all":[78],"the":[79,87,96,123],"responders.":[80],"Two":[81],"showed":[83],"exacerbation":[85],"disease.":[88],"No":[89],"toxic":[90],"drug":[91],"effect":[92],"noticed.":[94],"Although":[95],"mode":[97],"action":[99,109],"in":[102,122],"RA":[103],"appears":[104],"unclear,":[105],"its":[106,120],"high":[111],"response":[114],"should":[115],"encourage":[116],"further":[117],"use":[121],"treatment":[124],"RA.":[126]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}