{"id":"https://openalex.org/W2480262013","doi":"https://doi.org/10.1158/1538-7445.am2016-1867","title":"Abstract 1867: Activation of RHO-DIAPH signaling impairs RAS-driven exosome biogenesis","display_name":"Abstract 1867: Activation of RHO-DIAPH signaling impairs RAS-driven exosome biogenesis","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2480262013","doi":"https://doi.org/10.1158/1538-7445.am2016-1867","mag":"2480262013"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-1867","doi":"https://doi.org/10.1158/1538-7445.am2016-1867","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1867","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070723502","display_name":"Julie Davis-Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Davis-Turner","raw_affiliation_strings":["Van Andel Research Institute, Grand Rapids, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Research Institute, Grand Rapids, MI","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090213517","display_name":"Andrew M. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Howard","raw_affiliation_strings":["Van Andel Research Institute, Grand Rapids, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Research Institute, Grand Rapids, MI","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023869395","display_name":"Arthur S. Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S. Alberts","raw_affiliation_strings":["Van Andel Research Institute, Grand Rapids, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Research Institute, Grand Rapids, MI","institution_ids":["https://openalex.org/I1317189400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1317189400"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"1867","last_page":"1867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/exosome-biogenesis","display_name":"exosome biogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.640999972820282},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cell-blebbing","display_name":"cell blebbing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8050000071525574},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6582192778587341},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6407438516616821},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.6383411288261414},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6375470757484436},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5624013543128967},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5102047920227051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5029508471488953},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4852021038532257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47028353810310364},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.4612400233745575},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4325253963470459},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.4147886633872986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.232906311750412},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.1910657286643982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09592759609222412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-1867","doi":"https://doi.org/10.1158/1538-7445.am2016-1867","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1867","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088857882","https://openalex.org/W1975407027","https://openalex.org/W2137452721","https://openalex.org/W1977696467","https://openalex.org/W1984086927","https://openalex.org/W2072230642","https://openalex.org/W2026029310","https://openalex.org/W4391693880","https://openalex.org/W2025875460","https://openalex.org/W2562910628"],"abstract_inverted_index":{"Abstract":[0],"Like":[1],"oncogenic":[2,110],"RAS,":[3,111],"the":[4,15,27,45,52,122,131,238,243],"RAS":[5,150],"homologues":[6],"RHOA":[7],"and":[8,51,72,79,95,114,142,161,176,181,184],"RHOB":[9],"are":[10,59],"conventionally":[11],"thought":[12],"to":[13,104,124,158,190],"support":[14,41],"malignant":[16,66,92],"platform":[17],"by":[18,23,127,211],"governing":[19],"cell":[20],"structure":[21],"remodeling":[22],"effectors":[24],"that":[25,39,61,76,136],"include":[26],"Diaphanous":[28],"(DIAPH)":[29],"family":[30],"formins.":[31],"RHO-activated":[32],"DIAPHs":[33,80,160],"generate":[34],"linear":[35],"actin":[36],"filaments":[37],"(F-actin)":[38],"physically":[40],"membrane":[42],"protrusions":[43],"at":[44],"leading":[46],"edge":[47],"of":[48,54,87,130,174,202,227,237,242],"migrating":[49],"cells":[50,129],"trafficking":[53],"growth":[55],"factor":[56],"receptors,":[57],"which":[58],"processes":[60],"may":[62,188],"be":[63,191],"required":[64],"for":[65,98,195,246],"progression.":[67,93],"However,":[68],"our":[69],"cellular,":[70],"genetic,":[71],"pharmacological":[73,172],"studies":[74],"argue":[75],"both":[77],"RHO":[78,175,183],"function":[81,88],"as":[82],"tumor":[83,132],"suppressors":[84],"whose":[85],"loss":[86],"triggers":[89],"or":[90,207],"augments":[91],"DIAPH1":[94],"DIAPH3":[96],"inhibition,":[97],"example,":[99],"reduces":[100],"cortical":[101],"F-actin":[102],"sufficiently":[103],"cause":[105],"non-apoptotic":[106],"blebbing.":[107],"Combined":[108],"with":[109,169],"DIAPH":[112,177,185],"inhibition":[113],"blebbing":[115],"accelerate":[116],"exosome":[117,232],"release.":[118],"These":[119],"exosomes":[120],"have":[121,145,205,208],"capacity":[123],"foment":[125],"oncogenesis":[126,198],"seasoning":[128],"microenvironment":[133],"in":[134],"ways":[135],"promote":[137],"inflammation,":[138],"survival,":[139],"immune":[140],"escape,":[141],"metastasis.":[143],"We":[144],"identified":[146],"a":[147],"mechanism":[148],"whereby":[149],"uses":[151],"its":[152,163],"own":[153,164],"guanine-nucleotide":[154],"releasing":[155],"protein,":[156],"SOS,":[157],"inhibit":[159],"facilitate":[162],"escape":[165],"within":[166],"exosomes.":[167],"Consistent":[168],"this":[170],"idea,":[171],"activation":[173],"signaling":[178,204,229],"inhibits":[179],"tumorigenesis":[180],"invasion.":[182],"agonist/activation":[186],"strategies":[187],"prove":[189],"an":[192],"effective":[193],"alternative":[194],"impairing":[196],"RAS-driven":[197,231],"where":[199],"conventional":[200],"inhibitors":[201],"RAS-MAPK":[203],"failed":[206],"been":[209],"met":[210],"poorly":[212],"understood":[213],"resistance":[214],"mechanisms.":[215],"Citation":[216],"Format:":[217],"Julie":[218],"Davis-Turner,":[219],"Andrew":[220],"M.":[221],"Howard,":[222],"Arthur":[223],"S.":[224],"Alberts.":[225],"Activation":[226],"RHO-DIAPH":[228],"impairs":[230],"biogenesis.":[233],"[abstract].":[234],"In:":[235],"Proceedings":[236],"107th":[239],"Annual":[240],"Meeting":[241],"American":[244],"Association":[245],"Cancer":[247,258],"Research;":[248],"2016":[249],"Apr":[250],"16-20;":[251],"New":[252],"Orleans,":[253],"LA.":[254],"Philadelphia":[255],"(PA):":[256],"AACR;":[257],"Res":[259],"2016;76(14":[260],"Suppl):Abstract":[261],"nr":[262],"1867.":[263]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-08-23T00:00:00"}
