{"id":"https://openalex.org/W2480090539","doi":"https://doi.org/10.1186/s12906-016-1203-0","title":"Resistin mediates tomato and broccoli extract effects on glucose homeostasis in high fat diet-induced obesity in rats","display_name":"Resistin mediates tomato and broccoli extract effects on glucose homeostasis in high fat diet-induced obesity in rats","publication_year":2016,"publication_date":"2016-07-18","ids":{"openalex":"https://openalex.org/W2480090539","doi":"https://doi.org/10.1186/s12906-016-1203-0","mag":"2480090539","pmid":"https://pubmed.ncbi.nlm.nih.gov/27430475","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4949892"},"language":"en","primary_location":{"id":"doi:10.1186/s12906-016-1203-0","doi":"https://doi.org/10.1186/s12906-016-1203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12906-016-1203-0","pdf_url":null,"source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12906-016-1203-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035991248","display_name":"Nora M. Aborehab","orcid":"https://orcid.org/0000-0002-8871-7756","observed_orcids":["https://orcid.org/0000-0002-8871-7756"]},"institutions":[{"id":"https://openalex.org/I895027328","display_name":"October University of Modern Sciences and Arts","ror":"https://ror.org/01nvnhx40","country_code":"EG","type":"education","lineage":["https://openalex.org/I895027328"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nora M. Aborehab","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, MSA University, Giza, 11787, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, MSA University, Giza, 11787, Egypt","institution_ids":["https://openalex.org/I895027328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064157845","display_name":"Mahitab Helmy El Bishbishy","orcid":"https://orcid.org/0000-0002-0755-7229","observed_orcids":["https://orcid.org/0000-0002-0755-7229"]},"institutions":[{"id":"https://openalex.org/I895027328","display_name":"October University of Modern Sciences and Arts","ror":"https://ror.org/01nvnhx40","country_code":"EG","type":"education","lineage":["https://openalex.org/I895027328"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahitab H. El Bishbishy","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, MSA University, Giza, 11787, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, MSA University, Giza, 11787, Egypt","institution_ids":["https://openalex.org/I895027328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004525031","display_name":"Nermien E. Waly","orcid":"https://orcid.org/0000-0002-1722-3142","observed_orcids":["https://orcid.org/0000-0002-1722-3142"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Nermien E. Waly","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Helwan University, Helwan, 11787, Egypt. nwaly@icloud.com","Department of Physiology, Faculty of Medicine, Helwan University, Helwan, 11787, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Helwan University, Helwan, 11787, Egypt. nwaly@icloud.com","institution_ids":["https://openalex.org/I84058292"]},{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Helwan University, Helwan, 11787, Egypt","institution_ids":["https://openalex.org/I84058292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004525031"],"corresponding_institution_ids":["https://openalex.org/I84058292"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.0723,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.85505096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"225","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":1.0},{"id":"https://openalex.org/keywords/tomato-extract","display_name":"tomato extract","score":0.9950000047683716},{"id":"https://openalex.org/keywords/broccoli-extract","display_name":"broccoli extract","score":1.0},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dietary-phytochemicals","display_name":"dietary phytochemicals","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.9717322587966919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8089429140090942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7881325483322144},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7846421003341675},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.7404991984367371},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7102044820785522},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5974812507629395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.586837112903595},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5371755957603455},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.532017707824707},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5001862049102783},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.43413493037223816},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.40678903460502625}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001937","descriptor_name":"Brassica","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12906-016-1203-0","doi":"https://doi.org/10.1186/s12906-016-1203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12906-016-1203-0","pdf_url":null,"source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4949892","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4949892/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4949892/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complement Altern Med","raw_type":"Text"},{"id":"pmid:27430475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27430475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC complementary and alternative medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12906-016-1203-0","doi":"https://doi.org/10.1186/s12906-016-1203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12906-016-1203-0","pdf_url":null,"source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.6875,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309641","display_name":"Creighton University","ror":"https://ror.org/05wf30g94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2480090539.pdf","grobid_xml":"https://content.openalex.org/works/W2480090539.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1508194135","https://openalex.org/W1675830194","https://openalex.org/W1956057964","https://openalex.org/W1967161323","https://openalex.org/W1972501344","https://openalex.org/W1983599575","https://openalex.org/W1988752675","https://openalex.org/W1991550183","https://openalex.org/W1993836600","https://openalex.org/W1998926818","https://openalex.org/W2001186057","https://openalex.org/W2003289265","https://openalex.org/W2007534014","https://openalex.org/W2009225561","https://openalex.org/W2009722689","https://openalex.org/W2013184222","https://openalex.org/W2019428834","https://openalex.org/W2022589777","https://openalex.org/W2033522292","https://openalex.org/W2039762060","https://openalex.org/W2042221754","https://openalex.org/W2052326460","https://openalex.org/W2056150707","https://openalex.org/W2070885153","https://openalex.org/W2073756585","https://openalex.org/W2074914458","https://openalex.org/W2075577061","https://openalex.org/W2076695520","https://openalex.org/W2088297465","https://openalex.org/W2090603119","https://openalex.org/W2092805468","https://openalex.org/W2099816538","https://openalex.org/W2109850870","https://openalex.org/W2113625352","https://openalex.org/W2115861917","https://openalex.org/W2126327417","https://openalex.org/W2140304913","https://openalex.org/W2153753294","https://openalex.org/W2156161389","https://openalex.org/W2158246583","https://openalex.org/W2160234571","https://openalex.org/W2185225136","https://openalex.org/W2228632589","https://openalex.org/W2607031541","https://openalex.org/W4285719527","https://openalex.org/W6630405109"],"related_works":["https://openalex.org/W6977180955","https://openalex.org/W3012625401","https://openalex.org/W2023612431","https://openalex.org/W7096468155","https://openalex.org/W4362726546","https://openalex.org/W4246827726","https://openalex.org/W2049342816","https://openalex.org/W2188740876","https://openalex.org/W2121492052","https://openalex.org/W2368304878"],"abstract_inverted_index":{"BACKGROUND:":[0],"Resistin":[1],"is":[2],"an":[3],"adipocyte":[4],"hormone":[5],"that":[6,35,250],"regulates":[7,42,256],"glucose":[8,43,105,257],"metabolism.":[9],"Elevated":[10],"levels":[11,49,100,116,182,218],"of":[12,47,101,117,183,219,261],"resistin":[13,48,118,263],"may":[14,19,265],"cause":[15],"insulin":[16,31,107],"resistance.":[17,32],"This":[18],"link":[20],"obesity,":[21],"and":[22,30,39,91,106,112,132,152,162,178,206,252,264],"increased":[23,223],"fat":[24,52,72],"mass":[25],"to":[26,159,198,234],"type":[27],"II":[28],"diabetes":[29],"We":[33],"hypothesized":[34],"treatment":[36,255],"with":[37],"tomato":[38,251],"broccoli":[40,253],"extracts":[41],"homeostasis":[44,258],"via":[45,259],"modulation":[46],"in":[50,122,188,224],"high":[51],"diet-induced":[53],"obesity":[54],"rats":[55,61],"(HFD).":[56],"METHODS:":[57],"Forty-eight":[58],"male":[59],"albino":[60],"were":[62,108,119,171,185,221],"divided":[63],"into":[64],"8":[65],"groups":[66,134,208],"as":[67],"follows:":[68],"control,":[69],"HFD,":[70],"stop":[71],"diet":[73],"(SD),":[74],"Tomato":[75,79],"200":[76,84],"mg/kg":[77,81,85,89],"(T200),":[78],"400":[80,88,131,177,191,201,227],"(T400),":[82],"Broccoli":[83,87],"(B200),":[86],"(B400),":[90],"Chromax":[92],"(CX).":[93],"Treatment":[94],"continued":[95],"for":[96,271],"1":[97],"month.":[98],"Serum":[99,115,181,217],"resistin,":[102],"leptin,":[103],"adiponectin,":[104],"measured":[109],"using":[110],"ELISA":[111],"spectrophotometry.":[113],"RESULTS:":[114],"significantly":[120,186,222],"reduced":[121,187],"the":[123,189,199,225,235],"T":[124,126,174,190,226],"200,":[125,129],"400,":[127,175],"B":[128,130,176,200],"CX":[133,179,207,236],"to:":[135],"4.13":[136,144],"\u00b1":[137,141,145,149,154,193,203,210,230,239],"0.22":[138,146],"ng/ml,":[139,143,147,156],"1.51":[140],"0.04":[142],"2.32":[148],"0.15":[150],"ng/ml":[151],"1.37":[153],"0.03":[155],"respectively,":[157],"compared":[158,197,233],"HFD":[160],"group":[161,164,196,228,237],"SD":[163],"(P":[165],"value":[166,214,243],"<":[167,215,244],"0.0001).":[168],"Non-significant":[169],"differences":[170],"found":[172],"between":[173],"groups.":[180],"leptin":[184],"(22.7":[192],"0.84":[194],"pg/ml)":[195,232],"(41":[202],"2.45":[204],"Pg/ml)":[205],"(45.7":[209],"2.91":[211],"Pg/ml),":[212],"P":[213,242],"0.001.":[216],"adiponectin":[220],"(131":[229],"3.84":[231],"(112":[238],"4.77":[240],"pg/ml),":[241],"0.01.":[245],"CONCLUSIONS:":[246],"Our":[247],"results":[248],"demonstrate":[249],"extract":[254],"reduction":[260],"serum":[262],"be":[266],"a":[267],"useful":[268],"non-pharmacological":[269],"therapy":[270],"obesity.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-08-23T00:00:00"}
