{"id":"https://openalex.org/W2479670451","doi":null,"title":"Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts","display_name":"Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2479670451","mag":"2479670451"},"language":"en","primary_location":{"id":"mag:2479670451","doi":null,"is_oa":false,"landing_page_url":"https://www.ndorms.ox.ac.uk/publications/591910","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bone","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108103025","display_name":"Fraser P. Coxon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fraser P. Coxon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078343883","display_name":"Banafsh\u00e9 Larijani","orcid":"https://orcid.org/0000-0003-4735-1169","observed_orcids":["https://orcid.org/0000-0003-4735-1169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Banafsh\u00e9 Larijani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4735-1169","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012817393","display_name":"James E. Dunford","orcid":"https://orcid.org/0000-0002-9932-4042","observed_orcids":["https://orcid.org/0000-0002-9932-4042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Dunford","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9932-4042","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090216858","display_name":"Miguel C. Seabra","orcid":"https://orcid.org/0000-0002-6404-4892","observed_orcids":["https://orcid.org/0000-0002-6404-4892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel C. Seabra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6404-4892","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank H. Ebetino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9133-1360","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043757240","display_name":"Steven Paul Luckman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Luckman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081312172","display_name":"Michael J. Rogers","orcid":"https://orcid.org/0000-0002-1818-9249","observed_orcids":["https://orcid.org/0000-0002-1818-9249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Rogers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1818-9249","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22271173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenylation","display_name":"prenylation","score":0.625},{"id":"https://openalex.org/keywords/rab-gtpases","display_name":"Rab GTPases","score":0.9890000224113464},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.7129999995231628},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.37599998712539673},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.8954716920852661},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.8035993576049805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5536205172538757},{"id":"https://openalex.org/C23167141","wikidata":"https://www.wikidata.org/wiki/Q14912965","display_name":"Geranylgeranylation","level":4,"score":0.5510551929473877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5488038659095764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2641136348247528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21959465742111206},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10978236794471741},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.08719417452812195}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2479670451","doi":null,"is_oa":false,"landing_page_url":"https://www.ndorms.ox.ac.uk/publications/591910","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bone","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095554275","https://openalex.org/W1525770659","https://openalex.org/W2506472710","https://openalex.org/W2154553533","https://openalex.org/W1972765253","https://openalex.org/W2161235028","https://openalex.org/W1978047706","https://openalex.org/W1975805439","https://openalex.org/W4254017228","https://openalex.org/W2494410631"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-08-23T00:00:00"}