{"id":"https://openalex.org/W2478469897","doi":"https://doi.org/10.1158/1538-7445.am2015-344","title":"Abstract 344: Downregulation of osteoblastic N-cadherin decreases primary multiple myeloma cell - osteoblast interactions","display_name":"Abstract 344: Downregulation of osteoblastic N-cadherin decreases primary multiple myeloma cell - osteoblast interactions","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2478469897","doi":"https://doi.org/10.1158/1538-7445.am2015-344","mag":"2478469897"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-344","doi":"https://doi.org/10.1158/1538-7445.am2015-344","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-344","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350550","display_name":"Wenting Zhang","orcid":"https://orcid.org/0000-0002-8231-8527","observed_orcids":["https://orcid.org/0000-0002-8231-8527"]},"institutions":[{"id":"https://openalex.org/I108468826","display_name":"Stevens Institute of Technology","ror":"https://ror.org/02z43xh36","country_code":"US","type":"education","lineage":["https://openalex.org/I108468826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenting Zhang","raw_affiliation_strings":["1Stevens Institute of Technology, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stevens Institute of Technology, NJ;","institution_ids":["https://openalex.org/I108468826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091505058","display_name":"Yexin Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108468826","display_name":"Stevens Institute of Technology","ror":"https://ror.org/02z43xh36","country_code":"US","type":"education","lineage":["https://openalex.org/I108468826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yexin Gu","raw_affiliation_strings":["1Stevens Institute of Technology, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stevens Institute of Technology, NJ;","institution_ids":["https://openalex.org/I108468826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007814860","display_name":"Qiaoling Sun","orcid":"https://orcid.org/0000-0002-8472-6559","observed_orcids":["https://orcid.org/0000-0002-8472-6559"]},"institutions":[{"id":"https://openalex.org/I108468826","display_name":"Stevens Institute of Technology","ror":"https://ror.org/02z43xh36","country_code":"US","type":"education","lineage":["https://openalex.org/I108468826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiaoling Sun","raw_affiliation_strings":["1Stevens Institute of Technology, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stevens Institute of Technology, NJ;","institution_ids":["https://openalex.org/I108468826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023752321","display_name":"David Samuel DiCapua Siegel","orcid":"https://orcid.org/0000-0002-3604-2574","observed_orcids":["https://orcid.org/0000-0002-3604-2574"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Siegel","raw_affiliation_strings":["2Hackensack University Medical Center, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hackensack University Medical Center, NJ","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024799067","display_name":"Peter P. Tolias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108468826","display_name":"Stevens Institute of Technology","ror":"https://ror.org/02z43xh36","country_code":"US","type":"education","lineage":["https://openalex.org/I108468826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Tolias","raw_affiliation_strings":["1Stevens Institute of Technology, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stevens Institute of Technology, NJ;","institution_ids":["https://openalex.org/I108468826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006285787","display_name":"Zheng Yang","orcid":"https://orcid.org/0000-0003-4275-0590","observed_orcids":["https://orcid.org/0000-0003-4275-0590","https://orcid.org/0009-0003-0730-7873"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Yang","raw_affiliation_strings":["2Hackensack University Medical Center, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hackensack University Medical Center, NJ","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112828375","display_name":"Woo Lee","orcid":"https://orcid.org/0000-0001-6256-9786","observed_orcids":["https://orcid.org/0000-0001-6256-9786"]},"institutions":[{"id":"https://openalex.org/I108468826","display_name":"Stevens Institute of Technology","ror":"https://ror.org/02z43xh36","country_code":"US","type":"education","lineage":["https://openalex.org/I108468826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woo Lee","raw_affiliation_strings":["1Stevens Institute of Technology, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stevens Institute of Technology, NJ;","institution_ids":["https://openalex.org/I108468826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013268190","display_name":"Jenny Zilberberg","orcid":"https://orcid.org/0000-0002-4139-2616","observed_orcids":["https://orcid.org/0000-0002-4139-2616"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Zilberberg","raw_affiliation_strings":["2Hackensack University Medical Center, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hackensack University Medical Center, NJ","institution_ids":["https://openalex.org/I1324520350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"344","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-adhesion-mediated-drug-resistance","display_name":"cell adhesion-mediated drug resistance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5889999866485596},{"id":"https://openalex.org/keywords/3d-coculture","display_name":"3D coculture","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cd138-myeloma-cells","display_name":"CD138+ myeloma cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.515999972820282},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.5641394853591919},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5443200469017029},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5295031070709229},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5138178467750549},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5103232264518738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4822198152542114},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4729703962802887},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.4709811210632324},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.42609840631484985},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42480528354644775},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4102984070777893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4065009355545044},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32775360345840454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31197601556777954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2721244990825653},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.218120276927948},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16960057616233826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06449046730995178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-344","doi":"https://doi.org/10.1158/1538-7445.am2015-344","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-344","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990081266","https://openalex.org/W2112773873","https://openalex.org/W63381551","https://openalex.org/W2742009403","https://openalex.org/W1921751791","https://openalex.org/W2566045931","https://openalex.org/W3202125322","https://openalex.org/W44965294","https://openalex.org/W2577930248","https://openalex.org/W2321962535"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Recent":[2],"reports":[3],"have":[4],"shown":[5],"that":[6,56,141,258,328],"the":[7,31,68,75,96,106,115,148,161,176,182,197,222,274,284,304,316,322,338,349,361,418,423],"adhesion":[8],"molecule":[9,180],"N-cadherin,":[10],"a":[11,21,128,144,171,230,290,355,369],"mesenchymal":[12],"cadherin":[13],"associated":[14],"with":[15,225,229,345],"epithelial-to-mesenchymal":[16],"transition,":[17],"is":[18,53,90,331],"expressed":[19],"in":[20,57,147,166,181,186,196,221,303,315,335,360],"large":[22],"percentage":[23],"of":[24,77,95,109,118,154,163,178,184,192,233,240,269,340,363,403,417,422],"castration":[25],"resistant":[26],"prostate":[27,39],"cancer":[28,40],"tumors,":[29],"allowing":[30],"interaction":[32],"between":[33,64,343],"N-cadherin":[34,165,193,330,364,405],"expressing":[35],"osteoblasts":[36],"(OSB)":[37],"and":[38,45,49,67,80,152,189,235,238,249,253,379],"cells":[41,66,103,214],"via":[42],"homophilic":[43],"binding,":[44],"can":[46],"promote":[47],"osteoclastogenesis":[48],"osteolytic":[50],"disease.":[51],"There":[52],"also":[54],"evidence":[55],"multiple":[58,101,408],"myeloma":[59,102,409],"(MM),":[60],"direct":[61],"adhesive":[62],"interactions":[63,169,242,342],"MM":[65],"bone":[69,211],"marrow":[70,212],"stroma":[71],"are":[72],"responsible":[73],"for":[74,337,426],"development":[76,183,339],"drug":[78,87,377],"resistance":[79],"relapse.":[81],"This":[82],"phenomenon":[83],"termed":[84],"\u201ccell":[85],"adhesion-mediated":[86],"resistance\u201d":[88],"(CAMDR)":[89],"thought":[91],"to":[92,121,174,264,310,371,376],"be":[93],"one":[94],"major":[97],"mechanisms":[98],"by":[99,126,279,366],"which":[100],"(MMC)":[104],"escape":[105],"cytotoxic":[107],"effects":[108],"therapeutic":[110,357],"agents.":[111],"We":[112],"recently":[113],"demonstrated":[114,326],"technical":[116],"feasibility":[117],"culturing":[119],"difficult":[120],"preserve":[122],"primary":[123,407],"human":[124,198],"MMC":[125,218,260,300,344,373],"reconstructing":[127],"physiological":[129],"relevant":[130],"3D":[131],"microfluidic":[132,223],"bone-like":[133],"tissue":[134,305],"microenvironment.":[135,351],"Using":[136],"this":[137,157,179],"platform,":[138],"we":[139,159,325],"found":[140],"OSB":[142,199,319,367],"played":[143],"key":[145],"role":[146,162,177],"ex":[149],"vivo":[150],"maintenance":[151],"expansion":[153],"MMC.":[155],"In":[156],"study,":[158],"evaluated":[160],"osteoblastic":[164,329,404],"regulating":[167],"MMC-OSB":[168,241],"as":[170,283,368],"first":[172,323],"step":[173],"elucidate":[175],"CAMDR":[185],"MM.":[187],"Materials":[188],"Methods:":[190],"Knockdown":[191],"protein":[194],"expression":[195,365],"cell":[200,410],"line":[201],"hFOB":[202],"1.19":[203],"was":[204,243,277,301],"achieved":[205],"using":[206,245],"shRNA":[207],"lentiviral":[208],"technology.":[209],"Patient-derived":[210],"mononuclear":[213],"(BMMC)":[215],"containing":[216,307],"malignant":[217],"were":[219,261],"cocultured":[220],"device":[224],"either":[226],"N-cadherin+OSB":[227],"or":[228],"mixture":[231],"composed":[232],"N-cadherin-OSB":[234,308],"N-cadherin+OSB.":[236],"Monitoring":[237],"quantification":[239],"performed":[244],"time":[246],"lapsed":[247],"images":[248,256],"fluorescence":[250],"microscopy.":[251],"Results":[252],"Conclusions:":[254],"Real-time":[255],"showed":[257],"CD138+":[259,270,285,299],"preferentially":[262],"adhered":[263],"N-cadherin+":[265],"OSB.":[266],"The":[267],"retention":[268,314],"MMC,":[271],"based":[272],"on":[273],"scaffold":[275,306],"constitution,":[276],"determined":[278],"flow":[280],"cytometric":[281],"analyses":[282],"MMC/OSB":[286],"ratio.":[287],"Notably,":[288],"after":[289],"2":[291],"day":[292],"coculture":[293],"period,":[294],"only":[295],"32.78%":[296],"\u00b1":[297,312],"4.15%":[298],"retained":[302],"compared":[309],"70.21%":[311],"4.64%":[313],"mock":[317],"transfected":[318],"group.":[320],"For":[321],"time,":[324],"here":[327],"responsible,":[332],"at":[333],"least":[334],"part,":[336],"strong":[341],"stromal":[346],"elements":[347],"from":[348],"tumor":[350],"Our":[352],"data":[353],"suggest":[354],"new":[356],"intervention":[358],"area":[359],"modulation":[362],"way":[370],"render":[372],"more":[374],"susceptible":[375],"treatments":[378],"potentially":[380],"decrease":[381],"CAMDR.":[382],"Citation":[383],"Format:":[384],"Wenting":[385],"Zhang,":[386],"Yexin":[387],"Gu,":[388],"Qiaoling":[389],"Sun,":[390],"David":[391],"S.":[392],"Siegel,":[393],"Peter":[394],"Tolias,":[395],"Zheng":[396],"Yang,":[397],"Woo":[398],"Lee,":[399],"Jenny":[400],"Zilberberg.":[401],"Downregulation":[402],"decreases":[406],"-":[411],"osteoblast":[412],"interactions.":[413],"[abstract].":[414],"In:":[415],"Proceedings":[416],"106th":[419],"Annual":[420],"Meeting":[421],"American":[424],"Association":[425],"Cancer":[427,437],"Research;":[428],"2015":[429],"Apr":[430],"18-22;":[431],"Philadelphia,":[432],"PA.":[433],"Philadelphia":[434],"(PA):":[435],"AACR;":[436],"Res":[438],"2015;75(15":[439],"Suppl):Abstract":[440],"nr":[441],"344.":[442],"doi:10.1158/1538-7445.AM2015-344":[443]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-08-23T00:00:00"}
