{"id":"https://openalex.org/W2476976684","doi":"https://doi.org/10.1182/blood.v112.11.3017.3017","title":"A Phase III Study of Enoxaparin Versus Low-Dose Warfarin Versus Aspirin as Thromboprophylaxis for Patients with Newly Diagnosed Multiple Myeloma Treated up-Front with Thalidomide-Containing Regimens","display_name":"A Phase III Study of Enoxaparin Versus Low-Dose Warfarin Versus Aspirin as Thromboprophylaxis for Patients with Newly Diagnosed Multiple Myeloma Treated up-Front with Thalidomide-Containing Regimens","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2476976684","doi":"https://doi.org/10.1182/blood.v112.11.3017.3017","mag":"2476976684"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.3017.3017","doi":"https://doi.org/10.1182/blood.v112.11.3017.3017","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3017.3017","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071926851","display_name":"Mich\u00e8le Cavo","orcid":"https://orcid.org/0000-0003-4514-3227","observed_orcids":["https://orcid.org/0000-0003-4514-3227"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Cavo","raw_affiliation_strings":["Seragnoli Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seragnoli Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059967673","display_name":"Antonio Pierangelo Palumbo","orcid":"https://orcid.org/0000-0002-1763-6609","observed_orcids":["https://orcid.org/0000-0002-1763-6609"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Palumbo","raw_affiliation_strings":["Division of Hematology, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067110512","display_name":"Sara Bringhen","orcid":"https://orcid.org/0000-0003-4539-6363","observed_orcids":["https://orcid.org/0000-0003-4539-6363"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Bringhen","raw_affiliation_strings":["Division of Hematology, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021802241","display_name":"Antonietta Pia Falcone","orcid":"https://orcid.org/0000-0003-1070-8873","observed_orcids":["https://orcid.org/0000-0003-1070-8873"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonietta Falcone","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044869604","display_name":"Pellegrino Musto","orcid":"https://orcid.org/0000-0003-3277-6594","observed_orcids":["https://orcid.org/0000-0003-3277-6594"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pellegrino Musto","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026667594","display_name":"Fabio Ciceri","orcid":"https://orcid.org/0000-0003-0873-0123","observed_orcids":["https://orcid.org/0000-0003-0873-0123"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Ciceri","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011678278","display_name":"Mariella Grasso","orcid":"https://orcid.org/0000-0003-4766-806X","observed_orcids":["https://orcid.org/0000-0003-4766-806X"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariella Grasso","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066814162","display_name":"Renato Zambello","orcid":"https://orcid.org/0000-0002-8799-5324","observed_orcids":["https://orcid.org/0000-0002-8799-5324"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Zambello","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016753594","display_name":"Maria Concetta Petti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Concetta Petti","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066900720","display_name":"Fabrizio Ciambelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Ciambelli","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040797112","display_name":"Giovanni De Sabbata","orcid":"https://orcid.org/0000-0001-8048-1972","observed_orcids":["https://orcid.org/0000-0001-8048-1972"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni De Sabbata","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stefano Rocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Rocco","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110626724","display_name":"Luigi Gugliotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Gugliotta","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008693201","display_name":"Fil\u00edppo Gherlinzoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Gherlinzoni","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076571467","display_name":"Alfonso Maria D\u2019Arco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso D\u2019Arco","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Massimo Martelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Martelli","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017455719","display_name":"Tommasina Guglielmelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tommasina Guglielmelli","raw_affiliation_strings":["Italian Myeloma Network GIMEMA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Italian Myeloma Network GIMEMA, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051368482","display_name":"Paola Tacchetti","orcid":"https://orcid.org/0000-0001-9576-5118","observed_orcids":["https://orcid.org/0000-0001-9576-5118"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Tacchetti","raw_affiliation_strings":["Seragnoli Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seragnoli Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044224344","display_name":"Michele Baccarani","orcid":"https://orcid.org/0000-0003-1999-1687","observed_orcids":["https://orcid.org/0000-0003-1999-1687"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Baccarani","raw_affiliation_strings":["Dept. Hematology and Medical Oncology, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Hematology and Medical Oncology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018139001","display_name":"Mario Boccadoro","orcid":"https://orcid.org/0000-0001-8130-5209","observed_orcids":["https://orcid.org/0000-0001-8130-5209"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Boccadoro","raw_affiliation_strings":["Division of Hematology, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.6535,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9287048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"112","issue":"11","first_page":"3017","last_page":"3017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/low-dose-warfarin","display_name":"low-dose warfarin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.4869999885559082},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8450000286102295},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.828000009059906},{"id":"https://openalex.org/keywords/autologous-transplantation","display_name":"autologous transplantation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.5339999794960022},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9290992021560669},{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.8498585224151611},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5790227055549622},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5539747476577759},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.534677267074585},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.48784446716308594},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.4723958671092987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47194260358810425},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4660903513431549},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44933459162712097},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.43671706318855286},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3879799246788025},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v112.11.3017.3017","doi":"https://doi.org/10.1182/blood.v112.11.3017.3017","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3017.3017","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/19620","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/19620","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588067903","https://openalex.org/W2547124264","https://openalex.org/W2562265945","https://openalex.org/W2113020324","https://openalex.org/W2979417714","https://openalex.org/W3049176526","https://openalex.org/W2587789435","https://openalex.org/W2524140466","https://openalex.org/W2026895719","https://openalex.org/W1895520801"],"abstract_inverted_index":{"Abstract":[0],"Thalidomide-containing":[1],"regimens":[2,105,416,526],"are":[3,22,625],"currently":[4],"being":[5],"used":[6,45,260],"as":[7,86,261,430],"standard":[8],"initial":[9],"therapy":[10,102,299],"for":[11,156,240,350,378,396,434,460,492],"both":[12,171],"younger":[13],"and":[14,69,173,175,258,276,327,347,456,549,559,571,582,623],"elderly":[15,157],"pts":[16,94,124,213,249,290,317,345,397,435,461,521,562,614],"with":[17,24,103,125,151,227,364,368,372,478,482,486,523,569,586],"multiple":[18],"myeloma":[19],"(MM),":[20],"but":[21],"associated":[23,585],"an":[25],"increased":[26],"risk":[27,348,359,515,579,607],"of":[28,71,109,121,128,165,191,207,243,268,285,297,360,394,427,444,451,472,507,516,520,537,547,561,580,608],"venous":[29],"thromboembolism":[30],"(VTE)":[31],"which":[32],"necessitates":[33],"routine":[34],"thromboprophylaxis.":[35],"Controversies":[36],"exist":[37],"concerning":[38],"the":[39,53,67,107,116,144,241,247,283,286,310,314,358,388,425,502,508,513,534,545,606],"best":[40],"thromboprophylactic":[41,550,630],"regimen":[42],"to":[43,98,133,182,197,224,251,333,392,432,530,602,627],"be":[44,628],"in":[46,90,106,170,178,354,424,449,604],"these":[47,122,303,619],"pts.":[48],"To":[49],"address":[50],"this":[51],"issue,":[52],"Italian":[54],"Myeloma":[55],"Network":[56],"GIMEMA":[57],"designed":[58],"a":[59,187,203,421,575,590],"phase":[60,111],"III":[61,112],"sub-study":[62,211],"aimed":[63],"at":[64,293],"prospectively":[65],"investigating":[66],"efficacy":[68],"safety":[70],"low":[72],"molecular":[73],"weight":[74],"heparin":[75],"(LMWH)":[76],"or":[77,82,137,184,199,217,219,232,236,338,341,401,403,418,556],"fixed":[78,596],"low-dose":[79,83,597],"warfarin":[80],"(WAR)":[81],"aspirin":[84],"(ASA)":[85],"prophylaxis":[87,257],"against":[88],"VTE":[89,351,361,395,422,517,548,581,609],"newly":[91,611],"diagnosed":[92,612],"MM":[93,613],"who":[95,291],"were":[96,130,201,221,259,300,309,331,352,405,447,468],"randomized":[97,181,250,332],"receive":[99,134,225,255,334],"primary":[100],"induction":[101,244,298,552],"thalidomide-containing":[104,525,616],"context":[108],"2":[110],"studies":[113],"conducted":[114],"by":[115],"same":[117],"group.":[118],"In":[119,143,504,567],"one":[120],"studies,":[123],"\u226465":[126],"years":[127],"age":[129,560],"randomly":[131,222],"assigned":[132,196,223],"Velcade-Thalidomide-Dexamethasone":[135],"(VTD)":[136],"Thalidomide-Dexamethasone":[138],"(TD)":[139],"before":[140],"autologous":[141],"transplantation.":[142],"other":[145,278],"study,":[146],"Velcade-Melphalan-Prednisone":[147],"(VMP)":[148],"was":[149,167,362,385,476,499,527,542,574,599],"compared":[150,431],"VMP":[152,198,252,308],"plus":[153],"thalidomide":[154],"(VMPT)":[155],"patients":[158],"aged":[159],">65":[160],"years.":[161],"The":[162,442,470],"daily":[163],"dose":[164,190,206],"Thalidomide":[166],"200":[168],"mg":[169,177],"VTD":[172,183,216],"TD,":[174],"50":[176],"VMPT.":[179],"Pts":[180,413],"TD":[185,218,326,437],"received":[186,292],"total":[188,204],"Dexamethasone":[189],"320":[192],"mg/cycle,":[193],"while":[194,313,497],"those":[195],"VMPT":[200,220],"given":[202],"Prednisone":[205],"240":[208],"mg/m2/cycle.":[209],"By":[210],"design,":[212],"treated":[214,306,321,398,462,522],"on":[215,307,322,325,329,399,436,463],"thromboprophylaxis":[226],"LMWH":[228,336,369,400,479,570,603],"(Enoxaparin,":[229],"40":[230],"mg/d)":[231,235,239],"WAR":[233,339,365,402,455,483,598,622],"(1.25":[234],"ASA":[237,342,373,404,487,587,624],"(100":[238],"duration":[242],"therapy.":[245],"At":[246,282],"opposite,":[248],"did":[253],"not":[254,376,440,490,528,557,592,600],"any":[256,277],"controls.":[262,389,503],"Sub-study":[263],"end":[264],"points":[265],"included":[266],"incidence":[267,471],"VTE,":[269],"acute":[270],"cardiovascular":[271,445],"events,":[272],"sudden":[273,466],"death,":[274],"bleeding":[275,475,583],"serious":[279],"adverse":[280],"events.":[281],"time":[284],"present":[287,509],"analysis,":[288],"703":[289],"least":[294],"3":[295],"cycles":[296],"evaluated.":[301],"Of":[302],"pts,":[304,620],"164":[305],"control":[311],"group,":[312],"remaining":[315],"539":[316],"(of":[318],"whom,":[319],"209":[320],"VTD,":[323],"211":[324],"119":[328],"VMPT)":[330,419],"either":[335],"(n=178)":[337],"(n=180)":[340],"(n=181).":[343],"Baseline":[344],"characteristics":[346],"factors":[349],"comparable":[353],"all":[355,473],"sub-groups.":[356],"Overall,":[357],"3.9%":[363],"vs":[366,370,407,409,458,480,484,565],"4.5%":[367],"5.5%":[371],"(P":[374,438,488],"values":[375,489],"significant":[377,491,540],"comparisons":[379,493],"between":[380,494,544],"different":[381,495,524],"sub-groups),":[382,496],"whereas":[383],"it":[384,498],"1.8%":[386],"among":[387,501,518,610],"Median":[390],"times":[391],"onset":[393],"2.66":[406],"2.96":[408],"2.10":[410],"months,":[411],"respectively.":[412],"receiving":[414,615],"Velcade-containing":[415],"(VTD":[417],"had":[420],"frequency":[423,546],"range":[426],"approximately":[428],"3%,":[429],"5.8%":[433],"value":[439],"significant).":[441],"rates":[443],"events":[446],"0.6%":[448,477],"each":[450],"sub-groups":[452,519],"including":[453],"LMWH,":[454,621],"controls,":[457],"1.1%":[459,481],"ASA.":[464],"No":[465,539],"deaths":[467],"reported.":[469],"grades":[474],"3.3%":[485],"3.7%":[500],"conclusion,":[505],"results":[506],"analysis":[510],"show":[511],"that":[512,531],"overall":[514],"superior":[529],"expected":[532],"during":[533],"natural":[535],"course":[536],"MM.":[538],"relationship":[541],"found":[543],"regimens,":[551],"treatments":[553],"(e.g.":[554,563],"containing":[555],"Velcade)":[558],"young":[564],"elderly).":[566],"comparison":[568],"WAR,":[572],"there":[573],"higher,":[576],"albeit":[577],"marginal,":[578],"complications":[584],"prophylaxis.":[588],"Finally,":[589],"finding":[591],"previously":[593],"well":[594],"recognized,":[595],"inferior":[601],"reducing":[605],"regimens.":[617,631],"For":[618],"likely":[626],"effective":[629]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}