{"id":"https://openalex.org/W247682230","doi":null,"title":"Role of glutamate-199 in the aging of cholinesterase. (Reannouncement with new availability information)","display_name":"Role of glutamate-199 in the aging of cholinesterase. (Reannouncement with new availability information)","publication_year":1993,"publication_date":"1993-11-30","ids":{"openalex":"https://openalex.org/W247682230","mag":"247682230"},"language":"en","primary_location":{"id":"mag:247682230","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/210764-role-glutamate-aging-cholinesterase-reannouncement-new-availability-information","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008813139","display_name":"Ashima Saxena","orcid":"https://orcid.org/0000-0002-7289-1848","observed_orcids":["https://orcid.org/0000-0002-7289-1848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashima Saxena","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7289-1848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049372207","display_name":"B.P. Doctor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.P. Doctor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008006547","display_name":"Donald M. Maxwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald M. Maxwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109074975","display_name":"David E. Lenz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Lenz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054200641","display_name":"Zoran Radi\u0107","orcid":"https://orcid.org/0000-0003-0806-3869","observed_orcids":["https://orcid.org/0000-0003-0806-3869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoran Radi\u0107","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0806-3869","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02028944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/enzyme-aging","display_name":"enzyme aging","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glutamine-substitution","display_name":"glutamine substitution","score":0.7480000257492065},{"id":"https://openalex.org/keywords/soman","display_name":"soman","score":0.8100000023841858},{"id":"https://openalex.org/keywords/organophosphate-inhibition","display_name":"organophosphate inhibition","score":0.7870000004768372},{"id":"https://openalex.org/keywords/deacylation","display_name":"deacylation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxime-reactivation","display_name":"oxime reactivation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/inductive-effects","display_name":"inductive effects","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6559119820594788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6493297815322876},{"id":"https://openalex.org/C2776588719","wikidata":"https://www.wikidata.org/wiki/Q411097","display_name":"Organophosphate","level":3,"score":0.6188513040542603},{"id":"https://openalex.org/C2780266723","wikidata":"https://www.wikidata.org/wiki/Q408044","display_name":"Soman","level":4,"score":0.586959183216095},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.5717117190361023},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5490437746047974},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5052710175514221},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4733719229698181},{"id":"https://openalex.org/C90150868","wikidata":"https://www.wikidata.org/wiki/Q39513","display_name":"Alkoxy group","level":3,"score":0.46148672699928284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4288880527019501},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3736557364463806},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2992202043533325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1954934298992157},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1529141366481781},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11072593927383423},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.06738078594207764},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:247682230","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/210764-role-glutamate-aging-cholinesterase-reannouncement-new-availability-information","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088636647","https://openalex.org/W1778515962","https://openalex.org/W2001965999","https://openalex.org/W2019004975","https://openalex.org/W753353444","https://openalex.org/W2083898362","https://openalex.org/W2325602665","https://openalex.org/W2395525578","https://openalex.org/W2028756805","https://openalex.org/W2087762757"],"abstract_inverted_index":{"Aging":[0],"of":[1,8,15,28,69,106,109,118,137],"organophosphate-conjugated":[2],"acetylcholinesterase":[3],"results":[4],"from":[5],"the":[6,16,26,38,43,46,59,78,94,103,107,115,131,138],"loss":[7,108],"an":[9,127],"alkoxy":[10,139],"group":[11],"with":[12],"concomitant":[13],"stabilization":[14],"conjugate":[17,61],"to":[18,45,52,66,72,85,112,134],"spontaneous":[19],"or":[20],"nucleophile-induced":[21],"deacylation.":[22],"We":[23],"have":[24],"examined":[25],"kinetics":[27],"aging":[29,86,98],"in":[30,36],"a":[31,67],"pinacolylmethylphosphonofluoridate":[32],"(soman)-inhibited":[33],"mutant":[34,80],"enzyme":[35,70,81],"which":[37],"glutamate":[39],"(E199)":[40],"located":[41],"at":[42],"amino-terminal":[44],"active-site":[47],"sense":[48],"(S200)":[49],"was":[50,82,99],"converted":[51],"glutamine":[53],"(Q).":[54],"For":[55],"wild":[56],"type":[57],"enzyme,":[58],"soman-acetylcholinesterase":[60],"aged":[62],"immediately,":[63],"giving":[64],"rise":[65],"form":[68],"resistant":[71,84],"reactivation":[73],"by":[74,91],"oximes.":[75,92],"In":[76],"contrast,":[77],"E199Q":[79],"largely":[83],"and":[87],"could":[88],"be":[89,113],"reactivated":[90],"Since":[93],"pH":[95],"dependence":[96],"for":[97],"not":[100],"altered":[101],"appreciably,":[102],"primary":[104],"influence":[105],"charge":[110,122],"appears":[111],"on":[114,123,130],"intrinsic":[116],"rate":[117],"aging.":[119],"The":[120],"negative":[121],"E199":[124],"likely":[125],"imparts":[126],"inductive":[128],"effect":[129],"conjugated":[132],"organophosphate":[133],"facilitate":[135],"removal":[136],"group.":[140],"Cholinesterases,":[141],"Aging,":[142],"Organophosphate.":[143]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
