{"id":"https://openalex.org/W247629165","doi":null,"title":"Herpes simplex virus type 1 alters transcript levels of tumor necrosis factor-alpha and interleukin-6 in retinal glial cells.","display_name":"Herpes simplex virus type 1 alters transcript levels of tumor necrosis factor-alpha and interleukin-6 in retinal glial cells.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W247629165","mag":"247629165","pmid":"https://pubmed.ncbi.nlm.nih.gov/8843914"},"language":"en","primary_location":{"id":"pmid:8843914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8843914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041503539","display_name":"Kristen M. Drescher","orcid":"https://orcid.org/0000-0002-2513-5150","observed_orcids":["https://orcid.org/0000-0002-2513-5150"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Drescher","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21287-9142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21287-9142, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024683498","display_name":"Judith A. Whittum\u2010Hudson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Whittum-Hudson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5936,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82352941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"11","first_page":"2302","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.11029999703168869,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/retinal-glial-cells","display_name":"retinal glia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.7009999752044678},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anterior-chamber-infection","display_name":"anterior chamber infection","score":0.6380000114440918},{"id":"https://openalex.org/keywords/viral-retinitis","display_name":"viral retinitis","score":0.5770000219345093},{"id":"https://openalex.org/keywords/retinitis","display_name":"retinal inflammation","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7161777019500732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.710740864276886},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5784228444099426},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.566619336605072},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5570241808891296},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5506861805915833},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5391905307769775},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5251083970069885},{"id":"https://openalex.org/C2777168383","wikidata":"https://www.wikidata.org/wiki/Q4677951","display_name":"Acute retinal necrosis","level":5,"score":0.47004929184913635},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43891531229019165},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.42344918847084045},{"id":"https://openalex.org/C2777016524","wikidata":"https://www.wikidata.org/wiki/Q630552","display_name":"Retinitis","level":4,"score":0.4005652368068695},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.27269572019577026},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.25246289372444153},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.213291734457016},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2001933753490448},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09863206744194031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07911482453346252},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015828","descriptor_name":"Eye Infections, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8843914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8843914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.335","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.335","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/37/11/2302.full.pdf","raw_type":"text"},{"id":"mag:247629165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8843914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W3239780","https://openalex.org/W8522198","https://openalex.org/W20951468","https://openalex.org/W29996465","https://openalex.org/W35064164","https://openalex.org/W41798308","https://openalex.org/W63014164","https://openalex.org/W98762308","https://openalex.org/W149481866","https://openalex.org/W157675735","https://openalex.org/W172699736","https://openalex.org/W1497131246","https://openalex.org/W1504900014","https://openalex.org/W1521642954","https://openalex.org/W1534021813","https://openalex.org/W1547412330","https://openalex.org/W1549990240","https://openalex.org/W1810883461","https://openalex.org/W1903515437","https://openalex.org/W1964836954","https://openalex.org/W1974084948","https://openalex.org/W1976213001","https://openalex.org/W1991520979","https://openalex.org/W1994982942","https://openalex.org/W1996294113","https://openalex.org/W2005021221","https://openalex.org/W2008577129","https://openalex.org/W2011487629","https://openalex.org/W2012144305","https://openalex.org/W2016632842","https://openalex.org/W2031495251","https://openalex.org/W2035801686","https://openalex.org/W2036641356","https://openalex.org/W2042572340","https://openalex.org/W2045914497","https://openalex.org/W2049809617","https://openalex.org/W2056958245","https://openalex.org/W2061798311","https://openalex.org/W2063673975","https://openalex.org/W2069132198","https://openalex.org/W2073067855","https://openalex.org/W2093168164","https://openalex.org/W2095519131","https://openalex.org/W2097972613","https://openalex.org/W2102337767","https://openalex.org/W2110448743","https://openalex.org/W2117491739","https://openalex.org/W2122400789","https://openalex.org/W2135392289","https://openalex.org/W2147872401","https://openalex.org/W2158349270","https://openalex.org/W2162714996","https://openalex.org/W2166875164","https://openalex.org/W2174322658","https://openalex.org/W2292619439"],"related_works":["https://openalex.org/W7100243744","https://openalex.org/W2070293079","https://openalex.org/W1987489785","https://openalex.org/W1987449856","https://openalex.org/W2051723818","https://openalex.org/W2346033429","https://openalex.org/W2086296532","https://openalex.org/W1936828909","https://openalex.org/W2079909671","https://openalex.org/W1820255447"],"abstract_inverted_index":{"PURPOSE:":[0],"Studies":[1],"were":[2,27,34,73,109,154,245,277,309,347,362,386],"performed":[3],"to":[4,29,56,87,156,171,201,219,254,283,389,415,439,442,470],"determine":[5],"whether":[6,31],"retinal":[7,70,97,113,249,402,450],"M\u00fcller":[8,451],"cells":[9,115,404,452,469],"transcribe":[10],"genes":[11],"for":[12,90,378],"the":[13,37,145,151,226,423,427,464],"proinflammatory":[14],"cytokines":[15,33,67],"interleukin-6":[16],"(IL-6)":[17],"and":[18,92,103,137,236,242,294,305,343,356,359,409,434,460,462,477],"tumor":[19],"necrosis":[20],"factor-alpha":[21],"(TNF":[22],"alpha).":[23],"Isolated":[24],"murine":[25,146],"retinas":[26,166,192,312],"used":[28,86,155,200],"test":[30],"these":[32,66,266,447,467],"upregulated":[35,406],"in":[36,39,68,95,101,111,160,165,191,211,268,302,311,340,345,353,364,369],"retina":[38],"vivo":[40],"after":[41,174,281,334,392,413],"anterior":[42,175,319,424],"chamber":[43,176,320],"inoculation":[44],"of":[45,54,65,121,148,178,265,292,322,338,383,422,426,457,466,475],"herpes":[46],"simplex":[47],"virus":[48,416],"type":[49],"1":[50,170],"(HSV-1).":[51],"The":[52],"effects":[53],"exposure":[55,253,282,414],"HSV-1":[57,180,324,335,420],"or":[58,187,258,325,417],"interferon-gamma":[59],"(IFN":[60,260],"gamma)":[61,261],"on":[62],"transcript":[63,107,163,307,411],"levels":[64,108,164,190,264,276,308,373,382,412,437],"cultured":[69,96,112,248],"glia":[71],"also":[72],"examined.":[74],"METHODS:":[75],"In":[76,144,251],"situ":[77],"hybridization":[78,138],"(ISH)":[79],"using":[80,116],"digoxigenin":[81],"(DIG)-labeled":[82],"RNA":[83],"probes":[84],"was":[85,199,217],"localize":[88],"mRNA":[89,275,372,436],"IL-6":[91,102,241,286,306,346,357,379,395,410,435,461],"TNF":[93,104,243,273,303,341,354,370,384,407,432,458],"alpha":[94,105,244,274,304,342,355,371,385,408,433,459],"glial":[98,114,403],"cells.":[99],"Changes":[100],"relative":[106,161,203],"assessed":[110],"a":[117,269],"semiquantitative":[118],"approach":[119],"comprised":[120],"reverse":[122],"transcription-polymerase":[123],"chain":[124],"reaction":[125],"(RT-PCR)":[126],"assay":[127],"at":[128,397],"low":[129],"amplification":[130],"cycle":[131],"number":[132],"followed":[133],"by":[134,247],"slot":[135,212],"blotting":[136],"with":[139,189,207],"DIG-labeled":[140],"internal":[141],"sequence":[142],"probes.":[143],"model":[147],"herpetic":[149],"retinitis,":[150],"same":[152,227],"methods":[153],"compare":[157],"temporal":[158],"changes":[159,205,352,368],"cytokine":[162],"isolated":[167,193,313],"from":[168,194,225,314],"eyes":[169,366],"7":[172],"days":[173,391],"injection":[177],"live":[179],"(KOS":[181],"strain;":[182],"2":[183,388],"x":[184],"10(4)":[185],"pfu/eye)":[186],"buffer":[188],"normal,":[195],"uninjected":[196],"eyes.":[197],"Densitometry":[198],"quantify":[202],"signal":[204,216,223],"obtained":[206,224],"serial":[208],"diluted":[209],"samples":[210],"blot":[213],"assays.":[214],"Cytokine":[215],"normalized":[218],"hypoxanthine":[220],"phosphoribosyl":[221],"transferase":[222],"cDNA":[228],"samples.":[229],"RESULTS:":[230],"Under":[231],"baseline":[232],"culture":[233],"conditions,":[234],"ISH":[235],"RT-PCR":[237],"indicated":[238],"that":[239,317],"both":[240],"transcribed":[246],"glia.":[250],"vitro":[252],"either":[255,323],"viral":[256],"(HSV-1)":[257],"inflammatory":[259,418,478],"stimulants":[262],"increased":[263],"transcripts":[267],"time-dependent":[270],"manner.":[271],"Peak":[272],"detected":[278,310,387],"4":[279,288],"hours":[280,289],"HSV,":[284],"whereas":[285,349],"peaked":[287,396],"later":[290],"(increases":[291],"10.3":[293],"8.7":[295],"times":[296],"over":[297],"baseline,":[298],"respectively).":[299],"Differential":[300],"increases":[301,337],"BALB/c":[315],"mice":[316],"received":[318],"injections":[321],"Hanks'":[326],"balanced":[327],"salt":[328],"solution":[329],"(HBSS).":[330],"By":[331],"day":[332,398],"3":[333,390],"injection,":[336],"4.5-fold":[339],"17-fold":[344],"detected,":[348],"substantially":[350],"smaller":[351,440],"(1.5-fold":[358],"6.3-fold,":[360],"respectively)":[361],"observed":[363],"HBSS-injected":[365],"Virus-induced":[367],"occurred":[374],"slightly":[375],"earlier":[376],"than":[377],"because":[380],"maximal":[381],"infection,":[393],"but":[394],"3.":[399],"CONCLUSIONS:":[400],"Cultured":[401],"exhibit":[405],"mediators.":[419],"infection":[421],"segment":[425],"mouse":[428],"eye":[429],"markedly":[430],"upregulates":[431],"compared":[438],"responses":[441],"nonspecific":[443],"inflammation.":[444],"Taken":[445],"together,":[446],"results":[448],"identify":[449],"as":[453,472],"an":[454],"intraretinal":[455,473],"source":[456],"support":[463],"potential":[465],"resident":[468],"act":[471],"modulators":[474],"immune":[476],"responses.":[479]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}