{"id":"https://openalex.org/W2475407366","doi":"https://doi.org/10.1021/bk-2006-0939.ch003","title":"Metabolic Engineering of Escherichia coli for Short Chain Length-Medium Chain Length Polyhydroxyalkanoate Biosynthesis","display_name":"Metabolic Engineering of Escherichia coli for Short Chain Length-Medium Chain Length Polyhydroxyalkanoate Biosynthesis","publication_year":2006,"publication_date":"2006-09-23","ids":{"openalex":"https://openalex.org/W2475407366","doi":"https://doi.org/10.1021/bk-2006-0939.ch003","mag":"2475407366"},"language":"en","primary_location":{"id":"doi:10.1021/bk-2006-0939.ch003","doi":"https://doi.org/10.1021/bk-2006-0939.ch003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2006-0939.ch003","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1494359031","display_name":"Degradable Polymers and Materials"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043701519","display_name":"Christopher T. Nomura","orcid":"https://orcid.org/0000-0001-6981-5679","observed_orcids":["https://orcid.org/0000-0001-6981-5679"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Christopher T. Nomura","raw_affiliation_strings":["Polymer Chemistry Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-1098, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polymer Chemistry Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-1098, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112260329","display_name":"Yoshiharu Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiharu Doi","raw_affiliation_strings":["Polymer Chemistry Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-1098, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polymer Chemistry Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-1098, Japan","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210110652"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.18406593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"30","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14285","display_name":"Biopolymer Synthesis and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyhydroxyalkanoates","display_name":"polyhydroxyalkanoates","score":0.9959999918937683},{"id":"https://openalex.org/keywords/medium-chain-length-polyhydroxyalkanoates","display_name":"medium-chain-length polyhydroxyalkanoates","score":1.0},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8180000185966492},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pha-synthase","display_name":"PHA synthase","score":0.6489999890327454},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.7590000033378601},{"id":"https://openalex.org/keywords/thermal-properties-of-polymers","display_name":"polymer thermal properties","score":0.7870000004768372},{"id":"https://openalex.org/keywords/polymer-composition","display_name":"polymer composition","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C73447357","wikidata":"https://www.wikidata.org/wiki/Q425079","display_name":"Polyhydroxyalkanoates","level":3,"score":0.9873215556144714},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.798893928527832},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.768292248249054},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6088554859161377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5401983857154846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5400943756103516},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5253826379776001},{"id":"https://openalex.org/C119394753","wikidata":"https://www.wikidata.org/wiki/Q188245","display_name":"Polyester","level":2,"score":0.5017874240875244},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.48506441712379456},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.41903144121170044},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.3675389289855957},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33414074778556824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3308832049369812},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22654378414154053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15256941318511963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13203030824661255},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/bk-2006-0939.ch003","doi":"https://doi.org/10.1021/bk-2006-0939.ch003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2006-0939.ch003","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2144634347"],"related_works":["https://openalex.org/W2021225207","https://openalex.org/W7100510854","https://openalex.org/W2321207353","https://openalex.org/W4417362863","https://openalex.org/W2083294307","https://openalex.org/W2140821298","https://openalex.org/W2064193716","https://openalex.org/W2135804523","https://openalex.org/W7095225743","https://openalex.org/W7098141092"],"abstract_inverted_index":{"Polyhydroxyalkanoates":[0],"(PHA)s":[1],"are":[2,7,37,43,51,57,63,138],"microbially":[3],"produced":[4,124],"polyesters":[5],"that":[6],"biodegradable":[8],"and":[9,42,56,70,85,109,119,133],"have":[10],"a":[11],"wide":[12],"variety":[13],"of":[14,27,39,53,65,74,83,122],"uses.":[15],"PHAs":[16,36,50,62],"can":[17],"be":[18],"divided":[19],"into":[20,31],"three":[21],"groups":[22],"dependent":[23],"on":[24,79],"the":[25,28,32,72,75,80,117],"size":[26],"monomers":[29,41,55,66],"incorporated":[30],"polymer.":[33],"Shortchain-length":[34],"(SCL)":[35],"composed":[38,52,64],"C3-C5":[40],"thermoplastic":[44],"in":[45,59,68,94,125],"nature,":[46],"while":[47],"medium-chain-length":[48],"(MCL)":[49],"C6-C14":[54],"elastomeric":[58],"nature.":[60],"SCL-MCL":[61],"C3-C14":[67],"length":[69],"where":[71],"properties":[73,121],"polymer":[76],"vary":[77],"based":[78],"mol%":[81],"composition":[82,118],"SCL":[84,108],"MCL":[86,110],"monomers.":[87,112],"This":[88],"study":[89],"compares":[90],"various":[91],"monomersupplying":[92],"pathways":[93],"recombinant":[95,126],"Escherichia":[96],"coli":[97,128],"used":[98],"for":[99],"PHA":[100,111,131],"production":[101],"from":[102],"non-related":[103],"carbon":[104],"sources":[105],"to":[106],"supply":[107],"In":[113],"addition,":[114],"data":[115],"describing":[116],"thermal":[120],"polymers":[123],"E.":[127],"using":[129],"engineered":[130],"synthases":[132],"fatty":[134],"acid":[135],"biosynthesis":[136],"enzymes":[137],"presented.":[139]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}