{"id":"https://openalex.org/W2474974615","doi":null,"title":"Long-term timolol and epinephrine in monkeys. I. Functional morphology of the ciliary processes.","display_name":"Long-term timolol and epinephrine in monkeys. I. Functional morphology of the ciliary processes.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2474974615","mag":"2474974615","pmid":"https://pubmed.ncbi.nlm.nih.gov/3467494"},"language":"en","primary_location":{"id":"pmid:3467494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3467494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the ophthalmological societies of the United Kingdom","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079581811","display_name":"Elke L\u00fctjen-Drecoll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E L\u00fctjen-Drecoll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009911634","display_name":"Kaufman Pl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Kaufman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"M Eichhorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Eichhorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4741,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79293696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"105 ( Pt 2)","issue":null,"first_page":"180","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ciliary-processes","display_name":"ciliary processes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aqueous-humor-secretion","display_name":"aqueous humor secretion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ciliary-epithelium","display_name":"ciliary epithelium","score":0.7860000133514404},{"id":"https://openalex.org/keywords/long-term-drug-effects","display_name":"long-term drug effects","score":0.5950000286102295},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.5080000162124634},{"id":"https://openalex.org/keywords/phagolysosomes","display_name":"phagolysosomes","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pigment-granules","display_name":"pigment granules","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6909746527671814},{"id":"https://openalex.org/C2778073030","wikidata":"https://www.wikidata.org/wiki/Q413994","display_name":"Timolol","level":3,"score":0.6696627736091614},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6540821194648743},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5959291458129883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5685124397277832},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5442022681236267},{"id":"https://openalex.org/C2779105803","wikidata":"https://www.wikidata.org/wiki/Q2620085","display_name":"Ciliary processes","level":3,"score":0.5077654123306274},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5034946799278259},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.42101892828941345},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3989371061325073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23985204100608826},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.22509172558784485},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.09493884444236755},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09298652410507202}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013999","descriptor_name":"Timolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3467494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3467494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the ophthalmological societies of the United Kingdom","raw_type":"Journal Article"},{"id":"mag:2474974615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3467494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403203506","https://openalex.org/W2075961247","https://openalex.org/W1979753804","https://openalex.org/W2079467726","https://openalex.org/W1984469743","https://openalex.org/W1993619369","https://openalex.org/W2057836986","https://openalex.org/W15329461","https://openalex.org/W4242500480","https://openalex.org/W68069543"],"abstract_inverted_index":{"Cynomolgus":[0],"monkeys":[1,20,42,97],"were":[2],"treated":[3],"twice":[4],"daily":[5],"in":[6,36,91],"one":[7,99],"eye":[8],"with":[9,50,56,77,106,127,141,145],"timolol":[10],"180":[11],"micrograms":[12,27],"for":[13,21,28],"2.7,":[14],"6.0,":[15],"or":[16,24],"7.4":[17],"months":[18,30],"(2":[19,31],"each":[22],"period)":[23],"epinephrine":[25],"540-600":[26],"6.7":[29],"monkeys).":[32],"Some":[33],"ciliary":[34],"processes":[35,90],"both":[37,92],"eyes":[38,93],"of":[39,94,100,152],"all":[40],"timolol-treated":[41],"exhibited":[43,98],"light":[44],"and":[45,71,86,114,121,150],"electron":[46],"microscopic":[47],"changes":[48],"consistent":[49,140],"decreased":[51],"secretion:":[52],"narrowed":[53],"stromal":[54,104,125],"vessels":[55],"few":[57,69],"fenestrations":[58],"surrounded":[59],"by":[60],"a":[61],"thickened":[62,65],"fibre":[63],"sheath;":[64],"PE":[66,70,111],"basement":[67,112],"membrane;":[68],"NPE":[72,76,82,118],"basolateral":[73,119],"infoldings;":[74],"flattened":[75],"small":[78],"mitochondria.":[79],"Additionally,":[80],"the":[81,95,143],"contained":[83],"pigment":[84],"granules":[85],"large":[87],"phagolysosomes.":[88],"The":[89,135],"epinephrine-treated":[96],"two":[101],"pictures:":[102],"dilated":[103,124],"capillaries":[105,126],"numerous":[107,116],"fenestrations;":[108,129],"normal":[109],"stroma,":[110],"membrane":[113],"PE;":[115],"well-developed":[117],"infoldings":[120],"enlarged":[122],"mitochondria;":[123],"ruptured":[128],"ballooned":[130],"protein-filled":[131],"stroma;":[132],"degenerated":[133],"NPE.":[134],"first":[136],"picture":[137],"could":[138],"be":[139],"hypersecretion,":[142],"second":[144],"hyposecretion.":[146],"Possible":[147],"pathophysiological":[148],"explanations":[149],"implications":[151],"these":[153],"findings":[154],"are":[155],"discussed.":[156]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}