{"id":"https://openalex.org/W2474898321","doi":"https://doi.org/10.1186/s13058-016-0731-3","title":"Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence","display_name":"Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence","publication_year":2016,"publication_date":"2016-07-02","ids":{"openalex":"https://openalex.org/W2474898321","doi":"https://doi.org/10.1186/s13058-016-0731-3","mag":"2474898321","pmid":"https://pubmed.ncbi.nlm.nih.gov/27368476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4930566"},"language":"en","primary_location":{"id":"doi:10.1186/s13058-016-0731-3","doi":"https://doi.org/10.1186/s13058-016-0731-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-016-0731-3","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-016-0731-3","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-016-0731-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113622133","display_name":"Yuichiro Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Miyoshi","raw_affiliation_strings":["Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078426460","display_name":"Tadahiko Shien","orcid":"https://orcid.org/0000-0003-3202-5512","observed_orcids":["https://orcid.org/0000-0003-3202-5512"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadahiko Shien","raw_affiliation_strings":["Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan. tshien@md.okayama-u.ac.jp","Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan. tshien@md.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089549790","display_name":"Akiko Ogiya","orcid":"https://orcid.org/0000-0002-5949-9817","observed_orcids":["https://orcid.org/0000-0002-5949-9817"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Ogiya","raw_affiliation_strings":["Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110517331","display_name":"Naoko Ishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Ishida","raw_affiliation_strings":["Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011801222","display_name":"Kieko Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kieko Yamazaki","raw_affiliation_strings":["Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047235156","display_name":"Rie Horii","orcid":"https://orcid.org/0000-0002-4227-2739","observed_orcids":["https://orcid.org/0000-0002-4227-2739"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rie Horii","raw_affiliation_strings":["Division of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087541425","display_name":"Yoshiya Horimoto","orcid":"https://orcid.org/0000-0001-8935-0768","observed_orcids":["https://orcid.org/0000-0001-8935-0768"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiya Horimoto","raw_affiliation_strings":["Department of Breast Oncology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067189124","display_name":"Norikazu Masuda","orcid":"https://orcid.org/0000-0002-7302-0278","observed_orcids":["https://orcid.org/0000-0002-7302-0278"]},"institutions":[{"id":"https://openalex.org/I4210090372","display_name":"Osaka National Hospital","ror":"https://ror.org/00b6s9f18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090372","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norikazu Masuda","raw_affiliation_strings":["Breast Oncology, Department of Surgery, National Hospital Organization (NHO) Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, Osaka, 540-0006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Oncology, Department of Surgery, National Hospital Organization (NHO) Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, Osaka, 540-0006, Japan","institution_ids":["https://openalex.org/I4210090372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070884525","display_name":"Hiroyuki Yasojima","orcid":"https://orcid.org/0009-0005-3729-1520","observed_orcids":["https://orcid.org/0009-0005-3729-1520"]},"institutions":[{"id":"https://openalex.org/I4210090372","display_name":"Osaka National Hospital","ror":"https://ror.org/00b6s9f18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090372","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yasojima","raw_affiliation_strings":["Breast Oncology, Department of Surgery, National Hospital Organization (NHO) Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, Osaka, 540-0006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Oncology, Department of Surgery, National Hospital Organization (NHO) Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, Osaka, 540-0006, Japan","institution_ids":["https://openalex.org/I4210090372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111683199","display_name":"Touko Inao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Touko Inao","raw_affiliation_strings":["Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058192089","display_name":"Tomofumi Osako","orcid":"https://orcid.org/0000-0001-8449-7170","observed_orcids":["https://orcid.org/0000-0001-8449-7170"]},"institutions":[{"id":"https://openalex.org/I4210088918","display_name":"Kumamoto City Hospital","ror":"https://ror.org/007ge8322","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088918"]},{"id":"https://openalex.org/I4405253467","display_name":"Kumamoto Shinto General Hospital","ror":"https://ror.org/00pm9ra94","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253467"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomofumi Osako","raw_affiliation_strings":["Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, Kumamoto, Kumamoto, 862-8505, Japan","Present address: Kumamoto Shinto General Hospital, 1-17-27 Shinyashiki, Chuo-ku, Kumamoto, Kumamoto, 862-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, Kumamoto, Kumamoto, 862-8505, Japan","institution_ids":["https://openalex.org/I4210088918"]},{"raw_affiliation_string":"Present address: Kumamoto Shinto General Hospital, 1-17-27 Shinyashiki, Chuo-ku, Kumamoto, Kumamoto, 862-8655, Japan","institution_ids":["https://openalex.org/I4405253467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008946028","display_name":"Masato Takahashi","orcid":"https://orcid.org/0000-0002-6641-9598","observed_orcids":["https://orcid.org/0000-0002-6641-9598"]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210164631","display_name":"Sapporo National Hospital","ror":"https://ror.org/05afnhv08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210164631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Takahashi","raw_affiliation_strings":["Department of Breast Surgery, National Hospital Organization (NHO) Hokkaido Cancer Center, 4-2-3-54 Kikusui, Shiroishi-ku, Sapporo, Hokkaido, 003-0804, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, National Hospital Organization (NHO) Hokkaido Cancer Center, 4-2-3-54 Kikusui, Shiroishi-ku, Sapporo, Hokkaido, 003-0804, Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210164631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065803170","display_name":"Nobumoto Tomioka","orcid":"https://orcid.org/0000-0001-6751-416X","observed_orcids":["https://orcid.org/0000-0001-6751-416X"]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210164631","display_name":"Sapporo National Hospital","ror":"https://ror.org/05afnhv08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210164631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobumoto Tomioka","raw_affiliation_strings":["Department of Breast Surgery, National Hospital Organization (NHO) Hokkaido Cancer Center, 4-2-3-54 Kikusui, Shiroishi-ku, Sapporo, Hokkaido, 003-0804, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, National Hospital Organization (NHO) Hokkaido Cancer Center, 4-2-3-54 Kikusui, Shiroishi-ku, Sapporo, Hokkaido, 003-0804, Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210164631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004323435","display_name":"Yumi Wanifuchi\u2010Endo","orcid":"https://orcid.org/0000-0002-0703-2289","observed_orcids":["https://orcid.org/0000-0002-0703-2289"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumi Endo","raw_affiliation_strings":["Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109203676","display_name":"Mitsuchika Hosoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuchika Hosoda","raw_affiliation_strings":["Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072654198","display_name":"Hiroyoshi Doihara","orcid":"https://orcid.org/0000-0002-2989-2730","observed_orcids":["https://orcid.org/0000-0002-2989-2730"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyoshi Doihara","raw_affiliation_strings":["Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019730719","display_name":"Shinichiro Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Miyoshi","raw_affiliation_strings":["Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama-city, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009237974","display_name":"Hiroko Yamashita","orcid":"https://orcid.org/0000-0003-4281-8727","observed_orcids":["https://orcid.org/0000-0003-4281-8727"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Yamashita","raw_affiliation_strings":["Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Surgery, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan","institution_ids":["https://openalex.org/I4210141669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5078426460"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.0063,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84581213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.11559999734163284,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/early-recurrence","display_name":"early recurrence","score":0.5370000004768372},{"id":"https://openalex.org/keywords/late-recurrence","display_name":"late recurrence","score":0.925000011920929},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.41499999165534973},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7572804689407349},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7175558805465698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6702849864959717},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6132535338401794},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6087605357170105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5830501317977905},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5754095315933228},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.5624083876609802},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.5529640913009644},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4417400360107422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19437631964683533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/s13058-016-0731-3","doi":"https://doi.org/10.1186/s13058-016-0731-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-016-0731-3","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-016-0731-3","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmid:27368476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27368476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4930566","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4930566/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13058-016-0731-3","doi":"https://doi.org/10.1186/s13058-016-0731-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-016-0731-3","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-016-0731-3","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2624977163","display_name":"Study on clinicopathological characteristics and predictive factors for breast cancer with late recurrence","funder_award_id":"26461937","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320315964","display_name":"Japanese Breast Cancer Society","ror":"https://ror.org/03dfvhg70"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2474898321.pdf","grobid_xml":"https://content.openalex.org/works/W2474898321.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W57672764","https://openalex.org/W1060627342","https://openalex.org/W1775309324","https://openalex.org/W1835915349","https://openalex.org/W1880118344","https://openalex.org/W1905076687","https://openalex.org/W1966186646","https://openalex.org/W1968712753","https://openalex.org/W1978126655","https://openalex.org/W1988850647","https://openalex.org/W1994740289","https://openalex.org/W2014068090","https://openalex.org/W2015831734","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2025021524","https://openalex.org/W2074791527","https://openalex.org/W2077702574","https://openalex.org/W2080927137","https://openalex.org/W2093612156","https://openalex.org/W2094980833","https://openalex.org/W2099797262","https://openalex.org/W2134140348","https://openalex.org/W2137390086","https://openalex.org/W2137586381","https://openalex.org/W2137715553","https://openalex.org/W2141047569","https://openalex.org/W2145343734","https://openalex.org/W2148320927","https://openalex.org/W2158036908","https://openalex.org/W2159758950","https://openalex.org/W2165286055","https://openalex.org/W2166464943","https://openalex.org/W2171538667","https://openalex.org/W2173856988","https://openalex.org/W2182062247"],"related_works":["https://openalex.org/W2402142434","https://openalex.org/W2902782042","https://openalex.org/W2566894218","https://openalex.org/W2131011879","https://openalex.org/W2322256155","https://openalex.org/W1905076687","https://openalex.org/W2937485235","https://openalex.org/W2349915095","https://openalex.org/W1187662247","https://openalex.org/W2077702574"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,37,107,124],"significance":[2,338],"of":[3,6,20,39,45,126,279,339,342],"the":[4,18,43,104,135,163,171,185,191,215,246,277,326,336,340],"expression":[5,100,111,128,152,179,213,244,299,310],"aldehyde":[7],"dehydrogenase":[8],"1":[9,132],"(ALDH1),":[10],"a":[11,208,270,317],"cancer":[12,32,321,343],"stem":[13,344],"cell":[14],"marker,":[15],"for":[16,70,79],"predicting":[17,42,273],"recurrence":[19,46,69,116,140,173,187,193,219,250,280],"estrogen":[21],"receptor":[22,27],"(ER)-positive/human":[23],"epidermal":[24],"growth":[25],"factor":[26,271],"type":[28],"2":[29],"(HER2)-negative":[30],"breast":[31,81,296,320],"is":[33,332],"still":[34],"poorly":[35],"understood.":[36],"value":[38],"ALDH1":[40,93,99,110,127,151,178,212,243,267,298],"in":[41,84,120,134,170,184,190,211,242,252,303,325,351],"time":[44],"remains":[47],"unknown.":[48],"METHODS:":[49],"In":[50,264],"total,":[51],"184":[52],"patients":[53,59,67,293,327],"with":[54,60,155,294,305,316],"early":[55,172,186,216,306],"distant":[56,62],"recurrence,":[57,63,307],"134":[58],"late":[61,247],"and":[64,94,98,112,138,147,162,217,225,248,308,346],"321":[65],"control":[66],"without":[68,328],"more":[71,301,318],"than":[72,131,189,323],"10":[73],"years":[74],"after":[75,115,276],"starting":[76],"initial":[77],"treatment":[78],"ER-positive/HER2-negative":[80,295],"cancer,":[82,297],"registered":[83],"9":[85],"institutions,":[86],"were":[87,142],"analyzed.":[88],"We":[89],"assessed":[90],"relationships":[91],"between":[92,109,214,245],"other":[95],"clinicopathological":[96],"features,":[97],"was":[101,117,207,239,268,300,311],"compared":[102],"among":[103],"three":[105],"groups.":[106],"relationship":[108],"overall":[113,274],"survival":[114,275],"also":[118],"evaluated":[119],"each":[121],"group.":[122,174],"RESULTS:":[123],"rates":[125],"positivity":[129],"(more":[130],"%)":[133],"early,":[136],"late,":[137],"no":[139,192,218,240,249],"groups":[141,220,251],"18.4":[143],"%,":[144,146,149],"13.4":[145],"8.4":[148],"respectively.":[150],"correlated":[153],"significantly":[154,182],"lymph":[156],"node":[157],"metastases":[158],"(p":[159,167],"=":[160,203,262,289],"0.048)":[161],"Ki-67":[164],"labeling":[165],"index":[166],"<":[168,235],"0.001)":[169],"Multivariate":[175],"analysis":[176,254],"revealed":[177],"to":[180,313,334,347,353],"be":[181,314],"higher":[183],"group":[188,194],"(adjusted":[195,227,281],"OR":[196,228,282],"2.140,":[197],"95":[198,230,257,284],"%":[199,231,258,285],"CI":[200,232,259,286],"1.144-4.003,":[201],"p":[202,234,261,288],"0.016).":[204],"Moreover,":[205],"there":[206,238],"significant":[209],"difference":[210,241],"receiving":[221],"adjuvant":[222],"endocrine":[223],"therapy":[224],"chemotherapy":[226],"4.625,":[229],"1.881-12.474,":[233],"0.001).":[236],"However,":[237],"univariate":[253],"(OR":[255],"1.507,":[256],"0.738-2.998,":[260],"0.253).":[263],"multivariate":[265],"analysis,":[266],"not":[269],"independently":[272],"detection":[278],"1.451,":[283],"0.985-2.085,":[287],"0.059).":[290],"CONCLUSIONS:":[291],"Among":[292],"common":[302],"those":[304],"this":[309],"found":[312],"associated":[315],"aggressive":[319],"phenotype":[322],"that":[324],"recurrence.":[329],"Further":[330],"study":[331],"needed":[333],"clarify":[335],"prognostic":[337],"heterogeneity":[341],"cells":[345],"confirm":[348],"their":[349],"role":[350],"resistance":[352],"chemotherapy.":[354]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}