{"id":"https://openalex.org/W2474716347","doi":null,"title":"Non small cell lung cancer treatment with carboplatin and vindesine: a phase II study.","display_name":"Non small cell lung cancer treatment with carboplatin and vindesine: a phase II study.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2474716347","mag":"2474716347","pmid":"https://pubmed.ncbi.nlm.nih.gov/1332578"},"language":"en","primary_location":{"id":"pmid:1332578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1332578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014664627","display_name":"Sergio Bretti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122409","display_name":"Ospedale San Giovanni Antica Sede","ror":"https://ror.org/0321tdt28","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210122409"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Bretti","raw_affiliation_strings":["Ospedale San Giovanni Antica Sede, Dipartimento di Oncologia, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale San Giovanni Antica Sede, Dipartimento di Oncologia, Torino, Italy","institution_ids":["https://openalex.org/I4210122409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110412144","display_name":"G Bonardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Bonardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055186277","display_name":"A Celano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Celano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033483931","display_name":"Alessandro Comandone","orcid":"https://orcid.org/0000-0003-4677-1807","observed_orcids":["https://orcid.org/0000-0003-4677-1807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Comandone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060771978","display_name":"Chiara Casadio","orcid":"https://orcid.org/0000-0002-8760-1962","observed_orcids":["https://orcid.org/0000-0002-8760-1962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Casadio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041468034","display_name":"U Marchisio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Marchisio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010049452","display_name":"G Forconi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Forconi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033058370","display_name":"Sara Manzoni","orcid":"https://orcid.org/0000-0002-8902-1240","observed_orcids":["https://orcid.org/0000-0002-8902-1240","https://orcid.org/0009-0009-1119-5986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Manzoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024403801","display_name":"Cesare Bumma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bumma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"5","first_page":"1459","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vindesine","display_name":"vindesine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/outpatient-chemotherapy","display_name":"outpatient chemotherapy","score":0.5479999780654907},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8709999918937683},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5410000085830688},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.953000009059906},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779321808","wikidata":"https://www.wikidata.org/wiki/Q416660","display_name":"Vindesine","level":5,"score":0.945175051689148},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8804653882980347},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7686752080917358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7415433526039124},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6489059925079346},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6174569725990295},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5525696277618408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5431941151618958},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5084797143936157},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4432593882083893},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.42039045691490173},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41275298595428467},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38639596104621887},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.383942186832428},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32380783557891846},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.06337162852287292},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1332578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1332578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial"},{"id":"mag:2474716347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1332578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995475163","https://openalex.org/W4241526580","https://openalex.org/W2087006006","https://openalex.org/W2306955794","https://openalex.org/W2128166234","https://openalex.org/W1995542113","https://openalex.org/W2067436284","https://openalex.org/W1999444718","https://openalex.org/W2045268062","https://openalex.org/W2418326607"],"abstract_inverted_index":{"A":[0],"phase":[1],"II":[2],"trial":[3],"aiming":[4],"to":[5,21],"verify":[6],"the":[7,71,84,120],"effectiveness":[8],"of":[9,106,122],"a":[10,104],"regimen":[11],"including":[12],"carboplatin":[13,38],"and":[14,44,51,66,68,86],"vindesine":[15,45],"was":[16,63,78],"performed.":[17],"From":[18],"November":[19],"1989":[20],"September":[22],"1990,":[23],"nineteen":[24],"patients":[25],"with":[26,119],"advanced":[27],"small":[28],"cell":[29],"lung":[30],"cancer":[31],"entered":[32],"this":[33,98],"study.":[34],"Polychemotherapy":[35],"treatment":[36],"included:":[37],"400":[39],"mg/sm,":[40,47],"on":[41,48],"day":[42],"1":[43,50],"3":[46],"days":[49],"15,":[52],"repeated":[53],"every":[54],"4":[55,87],"weeks,":[56],"as":[57],"an":[58],"outpatient":[59],"regimen.":[60],"Observed":[61],"toxicity":[62],"mild;":[64],"myelodepression,":[65],"nausea":[67],"vomiting":[69],"were":[70,89],"main":[72],"adverse":[73],"events.":[74],"No":[75],"objective":[76,93],"response":[77,94],"obtained;":[79],"14":[80],"no":[81],"changes":[82],"in":[83,97],"disease":[85],"progressions":[88],"detected.":[90],"The":[91,110],"low":[92],"rate":[95],"observed":[96],"study":[99],"is":[100,117],"strongly":[101],"influenced":[102],"by":[103],"set":[105],"unfavourable":[107],"prognostic":[108],"factors.":[109],"median":[111],"overall":[112],"survival":[113],"time":[114],"[32":[115],"weeks]":[116],"comparable":[118],"results":[121],"other":[123],"studies.":[124]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
