{"id":"https://openalex.org/W2474586683","doi":null,"title":"C\u00e9lulas estaminais pluripotentes induzidas no estudo de mecanismos de doen\u00e7a e avalia\u00e7\u00e3o de novas terapias","display_name":"C\u00e9lulas estaminais pluripotentes induzidas no estudo de mecanismos de doen\u00e7a e avalia\u00e7\u00e3o de novas terapias","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2474586683","mag":"2474586683"},"language":"pt","primary_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/25942","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/25942","pdf_url":"http://hdl.handle.net/10316/25942","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10316/25942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067964170","display_name":"Liliana Correia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liliana Correia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067964170"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/somatic-cell-reprogramming","display_name":"somatic cell reprogramming","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ipsc-differentiation","display_name":"iPSC differentiation","score":0.640999972820282},{"id":"https://openalex.org/keywords/teratoma","display_name":"teratoma","score":0.7129999995231628},{"id":"https://openalex.org/keywords/disease-mechanisms","display_name":"disease mechanisms","score":0.6359999775886536},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/regeneration","display_name":"regeneration","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3619096875190735}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/25942","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/25942","pdf_url":"http://hdl.handle.net/10316/25942","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},{"id":"pmh:oai:estudogeral.uc.pt:10316/25942","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/25942","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/25942/1/Tese%20Mestrado%20Liliana%20Tavares%20Correia.pdf","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2474586683","doi":null,"is_oa":false,"landing_page_url":"https://estudogeral.sib.uc.pt/bitstream/10316/25942/1/Tese%20Mestrado%20Liliana%20Tavares%20Correia.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/25942","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/25942","pdf_url":"http://hdl.handle.net/10316/25942","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2474586683.pdf","grobid_xml":"https://content.openalex.org/works/W2474586683.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1558035100","https://openalex.org/W1837066193","https://openalex.org/W1966504370","https://openalex.org/W1967025085","https://openalex.org/W1967729506","https://openalex.org/W1971496676","https://openalex.org/W1978173381","https://openalex.org/W1981809048","https://openalex.org/W1981867466","https://openalex.org/W1985494276","https://openalex.org/W1989339219","https://openalex.org/W1992525863","https://openalex.org/W2017968214","https://openalex.org/W2019818957","https://openalex.org/W2030041716","https://openalex.org/W2034877388","https://openalex.org/W2037338370","https://openalex.org/W2045952188","https://openalex.org/W2050689355","https://openalex.org/W2053193370","https://openalex.org/W2057159461","https://openalex.org/W2065561114","https://openalex.org/W2066480270","https://openalex.org/W2068592712","https://openalex.org/W2083356601","https://openalex.org/W2086943348","https://openalex.org/W2090260381","https://openalex.org/W2092780119","https://openalex.org/W2095153534","https://openalex.org/W2096216062","https://openalex.org/W2098597036","https://openalex.org/W2099313405","https://openalex.org/W2101736621","https://openalex.org/W2102424187","https://openalex.org/W2104978512","https://openalex.org/W2109460321","https://openalex.org/W2110491077","https://openalex.org/W2125987139","https://openalex.org/W2138977668","https://openalex.org/W2142482111","https://openalex.org/W2150136533","https://openalex.org/W2157073241","https://openalex.org/W2157645703","https://openalex.org/W2166599552","https://openalex.org/W2167402830","https://openalex.org/W2170614891","https://openalex.org/W2328629659","https://openalex.org/W2795514060"],"related_works":["https://openalex.org/W7056302306","https://openalex.org/W7103245204","https://openalex.org/W7028435674","https://openalex.org/W7036570507","https://openalex.org/W7055057424","https://openalex.org/W7005384492","https://openalex.org/W7064678830","https://openalex.org/W2605498048","https://openalex.org/W7093626312","https://openalex.org/W6989886066"],"abstract_inverted_index":{"A":[0],"obten\u00e7\u00e3o":[1],"de":[2,13,38,43,46,54,57,82,84,90,150,161,168,219],"c\u00e9lulas":[3,14,30,65,73,94,106,110,220,229],"estaminais":[4,74,95,221,230],"pluripotentes":[5,96,231],"induzidas":[6],"(piscas)":[7],"a":[8,52,155,159,164,197,201],"partir":[9,53],"da":[10,22,41,114,213],"reprograma\u00e7\u00e3o":[11],"directa":[12],"som\u00e1ticas":[15,31],"foi":[16],"um":[17,36,44],"dos":[18,140,144,166,174],"avan\u00e7os":[19],"mais":[20],"importantes":[21],"biologia,":[23],"nos":[24],"\u00faltimos":[25],"anos.":[26],"As":[27,68],"iPSCs":[28,69,119],"s\u00e3o":[29,70],"que":[32,178,181,186,196],"foram":[33],"reprogramadas":[34],"para":[35,137],"estado":[37],"pluripot\u00eancia":[39],"atrav\u00e9s":[40],"introdu\u00e7\u00e3o":[42],"conjunto":[45],"factores":[47],"espec\u00edficos.":[48],"Podem":[49],"ser":[50,182],"obtidas":[51],"diferentes":[55,217],"tipos":[56,218],"c\u00e9lulas,":[58,194],"como":[59,86],"os":[60,148,216],"fibroblastos,":[61],"queratin\u00f3citos,":[62],"hepat\u00f3citos":[63],"e":[64,79,109,126,133,147,152,170,191,222],"do":[66,107,142],"sangue.":[67],"similares":[71],"\u00e0s":[72],"embrion\u00e1rias,":[75],"quer":[76],"na":[77,80,88],"morfologia":[78],"express\u00e3o":[81],"marcadores":[83],"pluripot\u00eancia,":[85],"tamb\u00e9m":[87],"capacidade":[89],"desenvolver":[91],"teratomas.":[92],"Como":[93],"podem":[97],"diferenciar-se":[98],"em":[99,205],"todas":[100],"as":[101,223],"linhagens":[102],"celulares,":[103],"incluindo":[104],"neur\u00f3nios,":[105],"sangue":[108],"card\u00edacas.":[111],"O":[112],"progresso":[113],"investiga\u00e7\u00e3o":[115],"no":[116,185],"dom\u00ednio":[117],"das":[118],"veio":[120],"demonstrar":[121],"o":[122,138],"seu":[123,171],"enorme":[124],"potencial":[125],"adquiriu":[127],"uma":[128,211],"consider\u00e1vel":[129],"relev\u00e2ncia":[130],"cient\u00edfica,":[131],"social":[132],"econ\u00f3mica":[134],"por":[135],"contribuir":[136],"conhecimento":[139],"processos":[141],"desenvolvimento":[143],"organismos":[145],"vivos":[146],"mecanismos":[149,167],"regenera\u00e7\u00e3o,":[151],"potencialmente":[153],"vir":[154],"permitir":[156],"transplante":[157],"celular,":[158],"descoberta":[160],"novos":[162],"f\u00e1rmacos,":[163],"identifica\u00e7\u00e3o":[165],"doen\u00e7as":[169],"tratamento.":[172],"Apesar":[173],"imensos":[175],"problemas":[176],"t\u00e9cnicos":[177],"ainda":[179],"t\u00eam":[180],"ultrapassados,":[183],"nomeadamente":[184],"diz":[187],"respeito":[188],"\u00e0":[189],"seguran\u00e7a":[190],"efic\u00e1cia":[192],"destas":[193],"espera-se":[195],"sua":[198],"utiliza\u00e7\u00e3o":[199],"venha":[200],"trazer":[202],"benef\u00edcios":[203],"inimagin\u00e1veis,":[204],"medicina":[206],"humana.":[207],"Nesta":[208],"disserta\u00e7\u00e3o":[209],"faz-se":[210],"revis\u00e3o":[212],"literatura":[214],"sobre":[215],"suas":[224],"caracter\u00edsticas":[225],"espec\u00edficas,":[226],"focando-se":[227],"nas":[228],"induzidas.":[232]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-07-22T00:00:00"}