{"id":"https://openalex.org/W2474366271","doi":"https://doi.org/10.1158/1541-7786.mcr-16-0088","title":"Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth","display_name":"Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth","publication_year":2016,"publication_date":"2016-07-12","ids":{"openalex":"https://openalex.org/W2474366271","doi":"https://doi.org/10.1158/1541-7786.mcr-16-0088","mag":"2474366271","pmid":"https://pubmed.ncbi.nlm.nih.gov/27401612"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-16-0088","doi":"https://doi.org/10.1158/1541-7786.mcr-16-0088","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-16-0088","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002480924","display_name":"Heather L. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Jackson","raw_affiliation_strings":["1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009684178","display_name":"David Granger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Granger","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015883250","display_name":"Gavin C. Jones","orcid":"https://orcid.org/0000-0001-9798-7566","observed_orcids":["https://orcid.org/0000-0001-9798-7566"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gavin Jones","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Louisa Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louisa Anderson","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062142338","display_name":"Sarah L. Friel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Friel","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087163902","display_name":"Daniel Rycroft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Rycroft","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886223","display_name":"William E. Fieles","orcid":"https://orcid.org/0009-0009-7440-3041","observed_orcids":["https://orcid.org/0009-0009-7440-3041"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Fieles","raw_affiliation_strings":["1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036380770","display_name":"James R. Tunstead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Tunstead","raw_affiliation_strings":["1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Steward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Steward","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064703104","display_name":"Trevor A. Wattam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Trevor Wattam","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527620","display_name":"Adam R. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Walker","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070817937","display_name":"Jeremy Griggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy Griggs","raw_affiliation_strings":["2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Biopharmaceuticals R&D, GlaxoSmithKline, Medicines Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079191784","display_name":"Muhammad Al\u2010Hajj","orcid":"https://orcid.org/0000-0001-5423-0758","observed_orcids":["https://orcid.org/0000-0001-5423-0758"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Al-Hajj","raw_affiliation_strings":["1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113872669","display_name":"Christopher A. Shelton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Shelton","raw_affiliation_strings":["1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113872669"],"corresponding_institution_ids":["https://openalex.org/I4210114143"],"apc_list":null,"apc_paid":null,"fwci":1.6841,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.83362995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"14","issue":"9","first_page":"859","last_page":"868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrp6","display_name":"LRP6","score":0.9300000071525574},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/r-spondin","display_name":"R-spondin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8694757223129272},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.7399580478668213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6630296111106873},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.500619649887085},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.468752384185791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4679991602897644},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4339163601398468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3871493935585022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36265307664871216},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3066178858280182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.264122873544693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14199110865592957},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1265222728252411},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1222960352897644}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019699","descriptor_name":"Thrombospondins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019699","descriptor_name":"Thrombospondins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019699","descriptor_name":"Thrombospondins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.mcr-16-0088","doi":"https://doi.org/10.1158/1541-7786.mcr-16-0088","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-16-0088","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:27401612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27401612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1571049310","https://openalex.org/W1577285263","https://openalex.org/W1963819880","https://openalex.org/W1989782611","https://openalex.org/W1994029539","https://openalex.org/W2006419043","https://openalex.org/W2013891209","https://openalex.org/W2016020712","https://openalex.org/W2018348035","https://openalex.org/W2029456301","https://openalex.org/W2034351801","https://openalex.org/W2051907575","https://openalex.org/W2065431388","https://openalex.org/W2069750786","https://openalex.org/W2078040721","https://openalex.org/W2078060536","https://openalex.org/W2082942439","https://openalex.org/W2083457841","https://openalex.org/W2084517025","https://openalex.org/W2089758057","https://openalex.org/W2093015940","https://openalex.org/W2097478805","https://openalex.org/W2102512718","https://openalex.org/W2104238625","https://openalex.org/W2106603079","https://openalex.org/W2118151336","https://openalex.org/W2129596910","https://openalex.org/W2155040292","https://openalex.org/W2155861726","https://openalex.org/W2166178545","https://openalex.org/W2170402173","https://openalex.org/W2258177869","https://openalex.org/W2419097647","https://openalex.org/W6634639825"],"related_works":["https://openalex.org/W2084517025","https://openalex.org/W2078040721","https://openalex.org/W2002037130","https://openalex.org/W4254406094","https://openalex.org/W7098510792","https://openalex.org/W2783865958","https://openalex.org/W2110651281","https://openalex.org/W3199461860","https://openalex.org/W7099202965","https://openalex.org/W4206759134"],"abstract_inverted_index":{"UNLABELLED:":[0],"Aberrant":[1],"WNT":[2,30,36,65,78],"signaling":[3],"is":[4,23,53],"associated":[5],"with":[6,33],"the":[7,24,29,59,110],"formation":[8],"and":[9,66,89,93],"growth":[10,96],"of":[11,28,55,61,64,103,112],"numerous":[12],"human":[13],"cancer":[14,86],"types.":[15],"The":[16],"low-density":[17],"lipoprotein":[18],"receptor-related":[19],"protein":[20],"6":[21],"(LRP6)":[22],"least":[25],"redundant":[26],"component":[27],"receptor":[31],"complex":[32],"two":[34],"independent":[35,124],"ligand-binding":[37],"sites.":[38],"Using":[39],"domain":[40],"antibody":[41,46],"(dAb)":[42],"technology,":[43],"a":[44,62,98,113],"bispecific":[45],"(GSK3178022)":[47],"to":[48,118,122],"LRP6":[49],"was":[50,73],"identified":[51],"that":[52],"capable":[54],"blocking":[56],"stimulation":[57],"in":[58,70,76,82,84,97],"presence":[60],"range":[63],"R-spondin":[67],"(RSPO)":[68],"ligands":[69],"vitro":[71],"GSK3178022":[72],"also":[74],"efficacious":[75],"reducing":[77],"target":[79],"gene":[80],"expression":[81],"vivo,":[83],"both":[85],"cell":[87],"line":[88],"patient-derived":[90,99],"xenograft":[91],"models,":[92],"delays":[94],"tumor":[95],"RSPO":[100],"fusion":[101],"model":[102],"colorectal":[104],"cancer.":[105],"IMPLICATIONS:":[106],"This":[107],"article":[108],"demonstrates":[109],"inhibition":[111,120],"key":[114],"oncogenic":[115],"receptor,":[116],"intractable":[117],"mAb":[119],"due":[121],"multiple":[123],"ligand":[125],"interaction":[126],"sites,":[127],"using":[128],"an":[129],"innovative":[130],"dAb":[131],"approach.":[132],"Mol":[133],"Cancer":[134],"Res;":[135],"14(9);":[136],"859-68.":[137],"\u00a92016":[138],"AACR.":[139]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}
