{"id":"https://openalex.org/W2473955286","doi":null,"title":"Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum beta-lactamase-producing organisms.","display_name":"Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum beta-lactamase-producing organisms.","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2473955286","mag":"2473955286","pmid":"https://pubmed.ncbi.nlm.nih.gov/14582562"},"language":"en","primary_location":{"id":"pmid:14582562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14582562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034549281","display_name":"Chi-Kin Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141770","display_name":"Pingtung Christian Hospital","ror":"https://ror.org/04bnbsh26","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210141770"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Kin Lan","raw_affiliation_strings":["Division of Infectious Diseases, Department of Internal Medicine, Ping-Tung Christian Hospital, Ping-Tong, Taiwan, ROC. 00543@ptch.org.tw","Division of Infectious Diseases, Department of Internal Medicine, Ping-Tung Christian Hospital, Ping-Tong, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Ping-Tung Christian Hospital, Ping-Tong, Taiwan, ROC. 00543@ptch.org.tw","institution_ids":["https://openalex.org/I4210141770"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Ping-Tung Christian Hospital, Ping-Tong, Taiwan, ROC","institution_ids":["https://openalex.org/I4210141770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019686478","display_name":"Po\u2010Ren Hsueh","orcid":"https://orcid.org/0000-0002-7502-9225","observed_orcids":["https://orcid.org/0000-0002-7502-9225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Po-Ren Hsueh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110860731","display_name":"Wing-Wai Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wing-Wai Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027425107","display_name":"Chang\u2010Phone Fung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang-Phone Fung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071796044","display_name":"Ya-Tin Lau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Tin Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089185849","display_name":"Jimmy Y K Yeung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jimmy Y K Yeung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006542292","display_name":"Grace T Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grace T Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110122512","display_name":"Ching\u2010Chyuan Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching-Chyuan Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.733,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.80782378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"36","issue":"3","first_page":"182","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-spectrum-beta-lactamase","display_name":"extended-spectrum beta-lactamase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ceftazidime-resistance","display_name":"ceftazidime resistance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.8519999980926514},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9980000257492065},{"id":"https://openalex.org/keywords/piperacillin-tazobactam","display_name":"piperacillin-tazobactam","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antibiotic-use","display_name":"antibiotic use","score":0.722000002861023},{"id":"https://openalex.org/keywords/antibiotic-stewardship","display_name":"antibiotic stewardship","score":0.6629999876022339},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.5950000286102295},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.6470000147819519},{"id":"https://openalex.org/keywords/formulary-restrictions","display_name":"formulary restrictions","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.906868577003479},{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.7358261346817017},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.6662472486495972},{"id":"https://openalex.org/C2778266534","wikidata":"https://www.wikidata.org/wiki/Q423376","display_name":"Tazobactam","level":5,"score":0.5941603779792786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5354955196380615},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.51751708984375},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5103408694267273},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49074873328208923},{"id":"https://openalex.org/C2781288988","wikidata":"https://www.wikidata.org/wiki/Q311379","display_name":"Beta-lactamase","level":4,"score":0.4809405207633972},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.44155073165893555},{"id":"https://openalex.org/C2777858937","wikidata":"https://www.wikidata.org/wiki/Q423376","display_name":"Piperacillin/tazobactam","level":5,"score":0.4251593053340912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3883400559425354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33109819889068604},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.20480063557624817},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.14737367630004883},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.10614526271820068},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.05459079146385193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077725","descriptor_name":"Piperacillin, Tazobactam Drug Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010878","descriptor_name":"Piperacillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018550","descriptor_name":"Cephalosporin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14582562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14582562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Journal Article"},{"id":"mag:2473955286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14582562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994376882","https://openalex.org/W2789814377","https://openalex.org/W2124795881","https://openalex.org/W2354955090","https://openalex.org/W2052458438","https://openalex.org/W7097125559","https://openalex.org/W2077892577","https://openalex.org/W7095240362","https://openalex.org/W2162459444","https://openalex.org/W7099540055"],"abstract_inverted_index":{"With":[0],"the":[1,30,35,38,48,54,62,71,81,98,109,125],"overuse":[2],"of":[3,9,32,40,50,56,64,83,113,118,121,129],"expanded-spectrum":[4],"cephalosporins,":[5],"especially":[6],"ceftazidime,":[7],"outbreaks":[8],"extended-spectrum":[10],"beta-lactamase":[11],"(ESBL)-producing":[12],"Klebsiella":[13],"pneumoniae":[14,93],"and":[15,37,61,85,115,127],"Escherichia":[16],"coli":[17,90],"infections":[18],"have":[19],"been":[20],"reported.":[21],"In":[22],"this":[23,104],"prospective":[24],"observational":[25],"study,":[26],"we":[27],"demonstrated":[28],"that":[29,111],"addition":[31],"piperacillin/tazobactam":[33,65],"to":[34,97,124],"formulary":[36],"restriction":[39],"ceftazidime":[41,57,119],"were":[42],"associated":[43],"with":[44],"a":[45,75],"decrease":[46,77],"in":[47,80,94],"percentage":[49,82],"ceftazidime-resistant":[51,131],"isolates.":[52],"When":[53],"use":[55,63,117],"decreased":[58],"by":[59,67,87],"96.43%,":[60],"increased":[66],"over":[68],"50%":[69],"during":[70],"9-month":[72,105],"study":[73,107],"period,":[74],"concomitant":[76],"was":[78],"found":[79],"colonization":[84],"infection":[86],"ESBL-producing":[88],"E.":[89],"or":[91],"K.":[92,132],"patients":[95],"admitted":[96],"intensive":[99],"care":[100],"unit.":[101],"Results":[102],"from":[103],"intervention":[106],"support":[108],"concept":[110],"levels":[112],"local":[114],"institutional":[116],"are":[120],"substantial":[122],"importance":[123],"emergence":[126],"persistence":[128],"endemic":[130],"pneumoniae.":[133]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-07-22T00:00:00"}