{"id":"https://openalex.org/W2473879451","doi":null,"title":"Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1","display_name":"Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2473879451","mag":"2473879451"},"language":"en","primary_location":{"id":"mag:2473879451","doi":null,"is_oa":false,"landing_page_url":"https://www.dpag.ox.ac.uk/publications/107774","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000520390","display_name":"Kay Horsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Horsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033412944","display_name":"Heidi de Wet","orcid":"https://orcid.org/0000-0002-9871-6909","observed_orcids":["https://orcid.org/0000-0002-9871-6909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi de Wet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9871-6909","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037178456","display_name":"C Langeveldt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Langeveldt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108216670","display_name":"F. S. Hough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Hough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034353167","display_name":"JM Burrin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JM Burrin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Cunningham","orcid":"https://orcid.org/0000-0002-0668-5982","observed_orcids":["https://orcid.org/0000-0002-0668-5982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Cunningham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0668-5982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042383829","display_name":"Mac\u00e9 Matthew Schuurmans","orcid":"https://orcid.org/0000-0001-5404-7566","observed_orcids":["https://orcid.org/0000-0001-5404-7566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mac\u00e9 M. Schuurmans","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5404-7566","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033503332","display_name":"P A Hulley","orcid":"https://orcid.org/0000-0002-4994-2264","observed_orcids":["https://orcid.org/0000-0002-4994-2264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Hulley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4994-2264","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24278565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"1030","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.1582999974489212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk-activity","display_name":"ERK activity","score":0.875},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mkp-1","display_name":"MKP-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mapk-phosphatase","display_name":"MAPK phosphatase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/transcriptional-upregulation","display_name":"transcriptional upregulation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.34599998593330383},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8939955830574036},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7606452703475952},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7017967104911804},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.600239634513855},{"id":"https://openalex.org/C2992339755","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transcriptional activity","level":4,"score":0.46014106273651123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45111966133117676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4308403730392456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4302200675010681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3270311951637268},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28288304805755615},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23263788223266602},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19658660888671875},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19206178188323975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16366812586784363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13538077473640442}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2473879451","doi":null,"is_oa":false,"landing_page_url":"https://www.dpag.ox.ac.uk/publications/107774","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":null},{"id":"mag:2504191982","doi":null,"is_oa":false,"landing_page_url":"https://www.dpag.ox.ac.uk/publications/107719","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bone","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159932176","https://openalex.org/W1968121880","https://openalex.org/W2487468764","https://openalex.org/W7096929005","https://openalex.org/W1820365993","https://openalex.org/W2159776951","https://openalex.org/W2013190549","https://openalex.org/W43995647","https://openalex.org/W2145906341","https://openalex.org/W2560876914"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-07-22T00:00:00"}
