{"id":"https://openalex.org/W2473874580","doi":null,"title":"The role of prostaglandines in peristalsis of the human colon.","display_name":"The role of prostaglandines in peristalsis of the human colon.","publication_year":1978,"publication_date":"1978-08-01","ids":{"openalex":"https://openalex.org/W2473874580","mag":"2473874580","pmid":"https://pubmed.ncbi.nlm.nih.gov/696206"},"language":"en","primary_location":{"id":"pmid:696206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/696206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta hepato-gastroenterologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108711312","display_name":"Bruch Hp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H P Bruch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066904686","display_name":"Eric Henrique Batista Schmidt","orcid":"https://orcid.org/0000-0001-6374-5307","observed_orcids":["https://orcid.org/0000-0001-6374-5307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000575955","display_name":"Richard Anthony Laven","orcid":"https://orcid.org/0000-0002-8938-8595","observed_orcids":["https://orcid.org/0000-0002-8938-8595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Laven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025780077","display_name":"G. Kehrer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kehrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087610566","display_name":"Wasner Kh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K H Wasner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6459,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78042498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"4","first_page":"303","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9430000185966492},{"id":"https://openalex.org/keywords/human-colon","display_name":"human colon","score":0.7429999709129333},{"id":"https://openalex.org/keywords/prostaglandin-e","display_name":"prostaglandin E","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prostaglandin-f","display_name":"prostaglandin F","score":1.0},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/prostaglandin-synthesis-inhibition","display_name":"prostaglandin synthesis inhibition","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prostaglandin-antagonists","display_name":"prostaglandin antagonists","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pentagastrin","display_name":"pentagastrin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/colonic-motility","display_name":"colonic motility","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C206813253","wikidata":"https://www.wikidata.org/wiki/Q308695","display_name":"Peristalsis","level":2,"score":0.9307366609573364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6030774116516113},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5673093199729919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5150644183158875},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5052326321601868},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.48977136611938477},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.4506051540374756},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44327303767204285},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.41763585805892944},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20582681894302368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17668494582176208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16395944356918335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1537974774837494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010418","descriptor_name":"Pentagastrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010528","descriptor_name":"Peristalsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011448","descriptor_name":"Prostaglandin Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:696206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/696206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta hepato-gastroenterologica","raw_type":"Journal Article"},{"id":"mag:2473874580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/696206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093096083","https://openalex.org/W2045558526","https://openalex.org/W2293627032","https://openalex.org/W2043958926","https://openalex.org/W2082878945","https://openalex.org/W1974576128","https://openalex.org/W596489272","https://openalex.org/W1416029928","https://openalex.org/W7143663068","https://openalex.org/W7100779194"],"abstract_inverted_index":{"Prostaglandines":[0],"(PG)":[1],"of":[2,16,43,80,97,109,117,122,127],"the":[3,17,49,56,62,115,120,125,128],"E":[4,45,111],"and":[5,31,46,59,82,92,101,112],"F":[6,47],"series":[7],"cause":[8],"peristaltic":[9,86],"activity":[10,87],"in":[11,48],"isolated":[12],"longitudinal":[13],"muscle":[14],"strips":[15],"human":[18,50],"colon.":[19],"As":[20],"this":[21],"phasic":[22],"motor":[23],"reaction":[24],"can":[25],"be":[26,67],"varied":[27],"by":[28,54,60,90,99,106],"acetyl":[29],"choline":[30],"adrenaline":[32],"it":[33],"was":[34,52,73,104],"supposed,":[35],"that":[36],"prostaglandines":[37],"contribute":[38],"to":[39,66],"peristalsis.":[40],"The":[41,78,95],"role":[42,121],"PG":[44,110,123],"colon":[51],"studied":[53],"inhibiting":[55],"prostaglandine":[57],"synthesis":[58],"antagonizing":[61],"prostaglandine-effects.":[63],"Indomethacin":[64,91,100],"proved":[65],"a":[68,75],"suitable":[69],"inhibitor.":[70],"HR":[71,93,102],"546":[72,103],"found":[74],"powerful":[76],"antagonist.":[77],"effect":[79],"Pentagastrin":[81],"Cholecystokinin":[83],"(CCK)":[84],"on":[85],"were":[88],"suppressed":[89],"546.":[94],"inhibition":[96],"peristalsis":[98],"removed":[105],"high":[107],"doses":[108],"F.":[113],"On":[114],"basis":[116],"these":[118],"results":[119],"for":[124],"motility":[126],"gut":[129],"is":[130],"discussed.":[131]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}