{"id":"https://openalex.org/W2473740959","doi":"https://doi.org/10.1097/mcp.0000000000000289","title":"Pharmacogenetics and interstitial lung disease","display_name":"Pharmacogenetics and interstitial lung disease","publication_year":2016,"publication_date":"2016-06-02","ids":{"openalex":"https://openalex.org/W2473740959","doi":"https://doi.org/10.1097/mcp.0000000000000289","mag":"2473740959","pmid":"https://pubmed.ncbi.nlm.nih.gov/27253772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004343"},"language":"en","primary_location":{"id":"doi:10.1097/mcp.0000000000000289","doi":"https://doi.org/10.1097/mcp.0000000000000289","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcp.0000000000000289","pdf_url":null,"source":{"id":"https://openalex.org/S188383068","display_name":"Current Opinion in Pulmonary Medicine","issn_l":"1070-5287","issn":["1070-5287","1531-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pulmonary Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004343","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009091055","display_name":"Justin M. Oldham","orcid":"https://orcid.org/0000-0003-4957-8869","observed_orcids":["https://orcid.org/0000-0003-4957-8869"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin M. Oldham","raw_affiliation_strings":["aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I40347166","https://openalex.org/I4210160527","https://openalex.org/I4387153466","https://openalex.org/I84218800"]},{"raw_affiliation_string":"aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006650120","display_name":"Imre Noth","orcid":"https://orcid.org/0000-0001-9846-5030","observed_orcids":["https://orcid.org/0000-0001-9846-5030"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imre Noth","raw_affiliation_strings":["Department of Medicine, Section of Pulmonary and Critical Care Medicine; The University of Chicago","aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Pulmonary and Critical Care Medicine; The University of Chicago","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100767595","display_name":"Fernando J. Mart\u00ednez","orcid":"https://orcid.org/0000-0002-2412-3182","observed_orcids":["https://orcid.org/0000-0002-2412-3182","https://orcid.org/0000-0003-4957-8869","https://orcid.org/0000-0001-8298-2703"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando J. Martinez","raw_affiliation_strings":["Department of Internal Medicine; Weill Cornell Medical School","aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine; Weill Cornell Medical School","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"aDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of California at Davis, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"bDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"cDepartment of Internal Medicine, Weill Cornell Medical School, New York City, New York, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009091055"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I40347166","https://openalex.org/I4210160527","https://openalex.org/I4387153466","https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.281,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.27466063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"5","first_page":"456","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":1.0},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/connective-tissue-disease-associated-interstitial-lung-disease","display_name":"connective tissue disease-associated interstitial lung disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8389999866485596},{"id":"https://openalex.org/keywords/drug-gene-interactions","display_name":"drug-gene interactions","score":0.7789999842643738},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tollip","display_name":"Tollip","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5699999928474426},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/disease-susceptibility-loci","display_name":"disease susceptibility loci","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9685529470443726},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.7963866591453552},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.5900651812553406},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.44992929697036743},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3853369355201721},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3067466616630554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28405869007110596},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12245482206344604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11792483925819397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06859025359153748},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1097/mcp.0000000000000289","doi":"https://doi.org/10.1097/mcp.0000000000000289","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcp.0000000000000289","pdf_url":null,"source":{"id":"https://openalex.org/S188383068","display_name":"Current Opinion in Pulmonary Medicine","issn_l":"1070-5287","issn":["1070-5287","1531-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pulmonary Medicine","raw_type":"journal-article"},{"id":"pmid:27253772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27253772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pulmonary medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4473428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004343","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5004343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004343","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pulm Med","raw_type":"Text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt86p2j949","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/86p2j949","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current opinion in pulmonary medicine, vol 22, iss 5","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt86p2j949","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/86p2j949","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Pulmonary Medicine, vol 22, iss 5","raw_type":"article"},{"id":"pmh:qt86p2j949","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/86p2j949","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oldham, JM; Noth, I; & Martinez, FJ. (2016). Pharmacogenetics and interstitial lung disease. Current Opinion in Pulmonary Medicine, 22(5), 456 - 465. doi: 10.1097/MCP.0000000000000289. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/86p2j949","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4473428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5004343","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000873713","display_name":"Research training in respiratory biology","funder_award_id":"T32HL007605","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W1515110078","https://openalex.org/W1538897678","https://openalex.org/W1549199866","https://openalex.org/W1569431722","https://openalex.org/W1920916096","https://openalex.org/W1964553743","https://openalex.org/W1966466614","https://openalex.org/W1970379805","https://openalex.org/W1971738121","https://openalex.org/W1975807940","https://openalex.org/W1977808352","https://openalex.org/W1984632007","https://openalex.org/W1984949703","https://openalex.org/W1985331805","https://openalex.org/W1985846684","https://openalex.org/W1987722665","https://openalex.org/W1993479562","https://openalex.org/W1994664175","https://openalex.org/W1998066609","https://openalex.org/W2000959749","https://openalex.org/W2004028427","https://openalex.org/W2004697839","https://openalex.org/W2005258545","https://openalex.org/W2008440267","https://openalex.org/W2012069459","https://openalex.org/W2013136572","https://openalex.org/W2015371796","https://openalex.org/W2016746301","https://openalex.org/W2016780435","https://openalex.org/W2017014359","https://openalex.org/W2019133821","https://openalex.org/W2024875479","https://openalex.org/W2024913341","https://openalex.org/W2028865413","https://openalex.org/W2031123734","https://openalex.org/W2037443445","https://openalex.org/W2037645843","https://openalex.org/W2042073625","https://openalex.org/W2044788332","https://openalex.org/W2047617638","https://openalex.org/W2050801931","https://openalex.org/W2052161026","https://openalex.org/W2052405801","https://openalex.org/W2055245602","https://openalex.org/W2055609841","https://openalex.org/W2055740721","https://openalex.org/W2057102103","https://openalex.org/W2057292199","https://openalex.org/W2058608805","https://openalex.org/W2058919781","https://openalex.org/W2072657098","https://openalex.org/W2083836105","https://openalex.org/W2091355977","https://openalex.org/W2097845477","https://openalex.org/W2098305693","https://openalex.org/W2103221430","https://openalex.org/W2104461707","https://openalex.org/W2104732389","https://openalex.org/W2107665433","https://openalex.org/W2108295593","https://openalex.org/W2108449402","https://openalex.org/W2113096218","https://openalex.org/W2115176808","https://openalex.org/W2115663067","https://openalex.org/W2115783720","https://openalex.org/W2116107710","https://openalex.org/W2117488044","https://openalex.org/W2119214281","https://openalex.org/W2120791222","https://openalex.org/W2123410953","https://openalex.org/W2124063170","https://openalex.org/W2131029325","https://openalex.org/W2132205159","https://openalex.org/W2134436842","https://openalex.org/W2136101247","https://openalex.org/W2136114918","https://openalex.org/W2138346322","https://openalex.org/W2138474497","https://openalex.org/W2138871107","https://openalex.org/W2140923971","https://openalex.org/W2142184306","https://openalex.org/W2143188326","https://openalex.org/W2145322825","https://openalex.org/W2145952542","https://openalex.org/W2146766013","https://openalex.org/W2146934518","https://openalex.org/W2148202382","https://openalex.org/W2150044222","https://openalex.org/W2150448842","https://openalex.org/W2150691073","https://openalex.org/W2150694579","https://openalex.org/W2152641884","https://openalex.org/W2152704304","https://openalex.org/W2157899215","https://openalex.org/W2165286737","https://openalex.org/W2167915961","https://openalex.org/W2168456091","https://openalex.org/W2168666423","https://openalex.org/W2170534284","https://openalex.org/W2187965582","https://openalex.org/W2222010516","https://openalex.org/W2315096416","https://openalex.org/W2318422569","https://openalex.org/W2400303083","https://openalex.org/W2402900764","https://openalex.org/W2413118602","https://openalex.org/W4250163698","https://openalex.org/W4297900576","https://openalex.org/W6632190573","https://openalex.org/W6715302053"],"related_works":["https://openalex.org/W4392619341","https://openalex.org/W3193535533","https://openalex.org/W4399884191","https://openalex.org/W7123390917","https://openalex.org/W2801316993","https://openalex.org/W4413396583","https://openalex.org/W2043798826","https://openalex.org/W4415175067","https://openalex.org/W4404616295","https://openalex.org/W1486462040"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Interstitial":[3],"lung":[4],"disease":[5,44,96,124],"(ILD)":[6],"is":[7],"comprised":[8],"of":[9,13,33,36,80,88,116,134,186,195],"a":[10,64,113,143],"heterogeneous":[11],"group":[12,115],"disorders":[14],"with":[15,71,92,121,150,166],"highly":[16],"variable":[17],"natural":[18],"histories":[19],"and":[20,53,61,100,189],"response":[21,31,152],"to":[22,94,106,127,147,153,168],"therapies.":[23],"Pharmacogenetics":[24],"focuses":[25],"on":[26],"the":[27,34],"variability":[28],"in":[29,69,137,164,176,192],"drug":[30,41],"because":[32],"presence":[35],"genetic":[37],"factors":[38],"that":[39,56],"influence":[40,58],"metabolism":[42],"or":[43],"activity.":[45],"In":[46],"this":[47,177],"article,":[48],"we":[49],"review":[50],"relevant":[51],"drug-specific":[52],"disease-specific":[54],"polymorphisms":[55,90],"may":[57],"therapeutic":[59],"response,":[60],"then":[62],"highlight":[63],"recently":[65],"identified":[66,142],"drug-gene":[67],"interaction":[68],"patients":[70,135,165],"idiopathic":[72],"pulmonary":[73],"fibrosis":[74],"(IPF).":[75],"RECENT":[76],"FINDINGS:":[77],"The":[78],"emergence":[79],"high-throughput":[81],"genomic":[82],"technology":[83],"has":[84],"allowed":[85],"for":[86,172],"identification":[87],"gene":[89],"associated":[91,120,149],"susceptibility":[93],"specific":[95,187],"states,":[97],"including":[98],"IPF":[99,109,139],"several":[101],"connective":[102,122],"tissue":[103,123],"diseases":[104],"known":[105],"cause":[107],"ILD.":[108],"risk":[110],"loci":[111],"span":[112],"diverse":[114],"genes,":[117],"while":[118],"most":[119],"are":[125],"critical":[126],"immune":[128],"signaling.":[129],"A":[130],"recent":[131],"pharmacogenetic":[132,159,173],"analysis":[133],"enrolled":[136],"an":[138,193],"clinical":[140],"trial":[141],"variant":[144],"within":[145],"TOLLIP":[146],"be":[148],"differential":[151],"N-acetylcysteine":[154],"therapy.":[155],"SUMMARY:":[156],"Though":[157],"few":[158],"investigations":[160],"have":[161],"been":[162],"conducted":[163],"ILD":[167],"date,":[169],"ample":[170],"opportunities":[171],"exploration":[174,181],"exist":[175],"patient":[178],"population.":[179],"Such":[180],"will":[182],"advance":[183],"our":[184],"understanding":[185],"ILDs":[188],"help":[190],"usher":[191],"era":[194],"personalized":[196],"medicine.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-07-22T00:00:00"}