{"id":"https://openalex.org/W2473679518","doi":"https://doi.org/10.1016/j.bmcl.2016.07.003","title":"DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity","display_name":"DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity","publication_year":2016,"publication_date":"2016-07-08","ids":{"openalex":"https://openalex.org/W2473679518","doi":"https://doi.org/10.1016/j.bmcl.2016.07.003","mag":"2473679518","pmid":"https://pubmed.ncbi.nlm.nih.gov/27432765"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2016.07.003","doi":"https://doi.org/10.1016/j.bmcl.2016.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2016.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069764111","display_name":"Sumathi Vodnala","orcid":"https://orcid.org/0000-0001-9997-3686","observed_orcids":["https://orcid.org/0000-0001-9997-3686"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumathi Vodnala","raw_affiliation_strings":["Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623745","display_name":"Anagani Kanaka Durga Bhavani","orcid":"https://orcid.org/0000-0002-5493-0663","observed_orcids":["https://orcid.org/0000-0002-5493-0663"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A.K.D. Bhavani","raw_affiliation_strings":["Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India. Electronic address: akdbhavaniou@yahoo.com","Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India. Electronic address: akdbhavaniou@yahoo.com","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057804045","display_name":"Ramakrishna Kamutam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramakrishna Kamutam","raw_affiliation_strings":["Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad 500004, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030188730","display_name":"V.G.M. Naidu","orcid":"https://orcid.org/0000-0003-1520-2177","observed_orcids":["https://orcid.org/0000-0003-1520-2177"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V.G.M. Naidu","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, India","institution_ids":["https://openalex.org/I4210146715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001550447","display_name":"Promila Promila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105094715","display_name":"National Institute of Technology Kurukshetra","ror":"https://ror.org/04909p852","country_code":"IN","type":"education","lineage":["https://openalex.org/I105094715"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Promila","raw_affiliation_strings":["Department of Chemistry, National Institute of Technology, Kurukshetra 36119, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Institute of Technology, Kurukshetra 36119, India","institution_ids":["https://openalex.org/I105094715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008827449","display_name":"Prabhakar Chetti","orcid":"https://orcid.org/0000-0003-1773-9429","observed_orcids":["https://orcid.org/0000-0003-1773-9429"]},"institutions":[{"id":"https://openalex.org/I105094715","display_name":"National Institute of Technology Kurukshetra","ror":"https://ror.org/04909p852","country_code":"IN","type":"education","lineage":["https://openalex.org/I105094715"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ch. Prabhakar","raw_affiliation_strings":["Department of Chemistry, National Institute of Technology, Kurukshetra 36119, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Institute of Technology, Kurukshetra 36119, India","institution_ids":["https://openalex.org/I105094715"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113623745"],"corresponding_institution_ids":["https://openalex.org/I8975392"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.0391,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.84835496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"16","first_page":"3973","last_page":"3977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dabco-catalysis","display_name":"DABCO catalysis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/one-pot-three-component-reaction","display_name":"one-pot three-component reaction","score":0.9480000138282776},{"id":"https://openalex.org/keywords/quinazolines","display_name":"quinazolines","score":0.8999999761581421},{"id":"https://openalex.org/keywords/4-hydroxycoumarin","display_name":"4-hydroxycoumarin","score":0.968999981880188},{"id":"https://openalex.org/keywords/ethyl-cyanoacetate","display_name":"ethyl cyanoacetate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mda-mb-453","display_name":"MDA-MB-453","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9027796983718872},{"id":"https://openalex.org/C2775995839","wikidata":"https://www.wikidata.org/wiki/Q423673","display_name":"DABCO","level":3,"score":0.852316677570343},{"id":"https://openalex.org/C2778866207","wikidata":"https://www.wikidata.org/wiki/Q426278","display_name":"Quinazoline","level":2,"score":0.7254146337509155},{"id":"https://openalex.org/C2777573524","wikidata":"https://www.wikidata.org/wiki/Q1146961","display_name":"Ethyl cyanoacetate","level":4,"score":0.6835482120513916},{"id":"https://openalex.org/C168395250","wikidata":"https://www.wikidata.org/wiki/Q898972","display_name":"Knoevenagel condensation","level":3,"score":0.5750492811203003},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5221560001373291},{"id":"https://openalex.org/C2777669036","wikidata":"https://www.wikidata.org/wiki/Q25323691","display_name":"4-Hydroxycoumarin","level":3,"score":0.4745030105113983},{"id":"https://openalex.org/C2908743524","wikidata":"https://www.wikidata.org/wiki/Q421311","display_name":"Benzopyrans","level":2,"score":0.42208701372146606},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4079475998878479},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3769662380218506},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.30493882298469543},{"id":"https://openalex.org/C2780513484","wikidata":"https://www.wikidata.org/wiki/Q419572","display_name":"Malononitrile","level":3,"score":0.2577561140060425}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2016.07.003","doi":"https://doi.org/10.1016/j.bmcl.2016.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2016.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:27432765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27432765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W928127617","https://openalex.org/W1832079080","https://openalex.org/W1965514142","https://openalex.org/W1972693487","https://openalex.org/W1975929220","https://openalex.org/W1992904941","https://openalex.org/W1996668995","https://openalex.org/W2013790981","https://openalex.org/W2015066697","https://openalex.org/W2017895219","https://openalex.org/W2050746381","https://openalex.org/W2064780710","https://openalex.org/W2073215333","https://openalex.org/W2075014255","https://openalex.org/W2087105387","https://openalex.org/W2093898933","https://openalex.org/W2107562129","https://openalex.org/W2112196673","https://openalex.org/W2127200971","https://openalex.org/W2134507150","https://openalex.org/W2140633565","https://openalex.org/W2329448026","https://openalex.org/W2951116386","https://openalex.org/W2951823897"],"related_works":["https://openalex.org/W2951460163","https://openalex.org/W1995593765","https://openalex.org/W4383907234","https://openalex.org/W4400510486","https://openalex.org/W2211780627","https://openalex.org/W4413765582","https://openalex.org/W4294891899","https://openalex.org/W2776898620","https://openalex.org/W2918374020","https://openalex.org/W4225777087"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}