{"id":"https://openalex.org/W2473527002","doi":"https://doi.org/10.1016/j.jcyt.2016.06.011","title":"Cellular therapy for sickle cell disease","display_name":"Cellular therapy for sickle cell disease","publication_year":2016,"publication_date":"2016-07-16","ids":{"openalex":"https://openalex.org/W2473527002","doi":"https://doi.org/10.1016/j.jcyt.2016.06.011","mag":"2473527002","pmid":"https://pubmed.ncbi.nlm.nih.gov/27421743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5067194"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcyt.2016.06.011","doi":"https://doi.org/10.1016/j.jcyt.2016.06.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2016.06.011","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5067194","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047262511","display_name":"Allistair Abraham","orcid":"https://orcid.org/0000-0003-2019-0887","observed_orcids":["https://orcid.org/0000-0003-2019-0887"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allistair Abraham","raw_affiliation_strings":["Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA; Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA. Electronic address: aabraham@childrensnational.org","Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA","Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA; Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA. Electronic address: aabraham@childrensnational.org","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069919013","display_name":"David Alex Jacobsohn","orcid":"https://orcid.org/0000-0001-6119-3270","observed_orcids":["https://orcid.org/0000-0001-6119-3270"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Jacobsohn","raw_affiliation_strings":["Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. Bollard","raw_affiliation_strings":["Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA; Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA","Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA","Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA; Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Blood and Marrow Transplant, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047262511"],"corresponding_institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.2745,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.29464286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"11","first_page":"1360","last_page":"1369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.781000018119812},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.8360000252723694},{"id":"https://openalex.org/keywords/donor-pool-expansion","display_name":"donor pool expansion","score":0.6380000114440918},{"id":"https://openalex.org/keywords/transplant-related-toxicity","display_name":"transplant toxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.8930000066757202},{"id":"https://openalex.org/keywords/curative-treatment","display_name":"curative treatment","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7150341272354126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6381028890609741},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5641931891441345},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5080652236938477},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4898674190044403},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.46628639101982117},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45173463225364685},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41404667496681213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4137202501296997},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.4134993553161621},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4099377989768982},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.3650675415992737},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3237476944923401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25412267446517944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15215876698493958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10887685418128967},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055611","descriptor_name":"Natural Killer T-Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jcyt.2016.06.011","doi":"https://doi.org/10.1016/j.jcyt.2016.06.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2016.06.011","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},{"id":"pmid:27421743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27421743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5067194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5067194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cytotherapy","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5067194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5067194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cytotherapy","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000874524","display_name":"Child Health Research Career Development Award (CHRCDA) Program at Children's National","funder_award_id":"K12HD001399","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W106664028","https://openalex.org/W109685203","https://openalex.org/W223872111","https://openalex.org/W1508585281","https://openalex.org/W1578616498","https://openalex.org/W1590229730","https://openalex.org/W1739877791","https://openalex.org/W1763433851","https://openalex.org/W1900619885","https://openalex.org/W1962573931","https://openalex.org/W1967250460","https://openalex.org/W1973683879","https://openalex.org/W1975255476","https://openalex.org/W1978164777","https://openalex.org/W1978492568","https://openalex.org/W1979593849","https://openalex.org/W1984858697","https://openalex.org/W1984887661","https://openalex.org/W1993948415","https://openalex.org/W1995325755","https://openalex.org/W1995698717","https://openalex.org/W1997713243","https://openalex.org/W2000643138","https://openalex.org/W2001175629","https://openalex.org/W2001887791","https://openalex.org/W2010832266","https://openalex.org/W2023449596","https://openalex.org/W2033230449","https://openalex.org/W2033284503","https://openalex.org/W2037513888","https://openalex.org/W2038413306","https://openalex.org/W2041475104","https://openalex.org/W2050996699","https://openalex.org/W2053431904","https://openalex.org/W2057879405","https://openalex.org/W2060745772","https://openalex.org/W2065697585","https://openalex.org/W2066214953","https://openalex.org/W2077174747","https://openalex.org/W2079460083","https://openalex.org/W2081730646","https://openalex.org/W2086216198","https://openalex.org/W2100764718","https://openalex.org/W2115657655","https://openalex.org/W2136274459","https://openalex.org/W2138719823","https://openalex.org/W2138946470","https://openalex.org/W2141825721","https://openalex.org/W2151676424","https://openalex.org/W2152076865","https://openalex.org/W2154323693","https://openalex.org/W2156338907","https://openalex.org/W2160181865","https://openalex.org/W2166262520","https://openalex.org/W2166541673","https://openalex.org/W2170086069","https://openalex.org/W2188172476","https://openalex.org/W2189616037","https://openalex.org/W2313841032","https://openalex.org/W2314213298","https://openalex.org/W2334263927","https://openalex.org/W2337931770","https://openalex.org/W2407981502","https://openalex.org/W2473585127","https://openalex.org/W2531079824","https://openalex.org/W2552487175","https://openalex.org/W2554173988","https://openalex.org/W2554804963","https://openalex.org/W2582860375","https://openalex.org/W3141197395"],"related_works":["https://openalex.org/W4391516358","https://openalex.org/W3118258306","https://openalex.org/W7160839896","https://openalex.org/W2971570376","https://openalex.org/W2899915044","https://openalex.org/W2756064341","https://openalex.org/W3193790900","https://openalex.org/W4309844169","https://openalex.org/W2952044183","https://openalex.org/W4408360535"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}
